Newswise — BALTIMORE—A University of Maryland School of Medicine (UMSOM), Center for Vaccine Development and Global Health (CVD), expert is co-leading an ongoing study that was pivotal in recommending adults and teens receive booster COVID-19 shots of their choosing starting in fall 2021. The preliminary clinical trial results, reported today in The New England Journal of Medicine, found that is safe and effective to receive boosters that are the same or a different one from the person’s primary vaccine(s).
Kirsten E. Lyke, MD, Professor of Medicine at UMSOM, is Co-Chair and site Principal Investigator for the study and presented data to the U.S. Food and Drug Administration’s (FDA) expert vaccine panel in October that led to the recommendation for mix-and-match booster doses following completion of Emergency Use Authorization (EUA) regimens.
“This study was pivotal in contributing knowledge about the safety and immune responses of mixing and matching primary vaccines and boosters,” said Dr. Lyke, who is also the Director of CVD’s Malaria Vaccine and Challenge Unit. “Boosters are critical against emerging variants of concern, such as the Delta and Omicron variants. The boosters provide an important tool to prevent severe disease, hospitalization, and death.”
Meagan Deming, MD, PhD, Instructor of Medicine at the UMSOM, is Vice-Chair of the study, which is a collaboration between investigators at the UMSOM’s CVD and the Institute of Human Virology (IHV). IHV investigators Jennifer Husson, MD, MPH, Joel Chua, MD, and Angie Price, DNP, MSN, CRNP, worked with CVD faculty on this study. The UMSOM Vaccine Treatment and Evaluation Unit (VTEU) is part of the Infectious Diseases Clinical Research Consortium (IDCRC) that investigated the mix-and-match boosters.
The newly published study found that for adults who previously received a full regimen of any COVID-19 vaccine granted EUA or approved by the FDA, an additional booster dose of any of these vaccines was safe and prompted an immune response. The ability to use vaccines for boosting that are different from those used for the primary series – mix and matching – can simplify vaccine booster administration.
These findings are from an ongoing phase 1/2 trial conducted under the UMSOM’s VTEU as part of the IDCRC and sponsored by the National Institute of Allergy and Infectious Diseases (NIAID) at the National Institutes of Health.
The NEJM report describes findings from 458 adult volunteers who had been fully vaccinated with one of the three EUA COVID-19 vaccines at least 12 weeks prior to enrollment. Of those volunteers, 150 study participants received a booster of Johnson & Johnson’s Ad26.CoV2-S vaccine; 154 received a booster of Moderna’s mRNA-1273 vaccine (100 microgram dose); and 154 received a booster of Pfizer-BioNTech’s BNT162b2.
The IDCRC trial, which began enrollment in May 2021, is led by Co-Chairs Robert L. Atmar, MD, of Baylor College of Medicine, Houston, Texas, and Dr. Lyke at the UMSOM.
“Mix-and-match is not a new approach. It is a well-known principle in vaccine science research. Mixing vaccine platforms can elicit a stronger, longer-lasting response than a single vaccine regimen and could help us fight variants,” said Dr. Lyke.
At 15 days after booster vaccination, serum antibody levels increased in all study groups, and leveled off by day 29. For a given primary EUA COVID-19 vaccine, administering a different vaccine as a booster elicited similar or higher serologic responses as compared to their respective homologous booster response. Additionally, T cell responses were measured. Cellular CD4 Th1 T cell responses directed against the spike protein increased in all groups except volunteers who received a single dose of Johnson & Johnson followed by a booster of Johnson & Johnson. However, CD8 T cell responses were more durable in Johnson & Johnson recipients and those who received an mRNA primary series followed by a Johnson & Johnson boost.
Booster vaccines may enhance waning immunity and expand the breadth of immunity against SARS-CoV-2 variants of concern. Heterologous prime-boost strategies may offer immunological advantages to optimize the breadth and longevity of protection achieved with currently available vaccines. They may also simplify the logistics of administering booster vaccines.
“Three COVID-19 vaccines have reached approval or EUA in the U.S. The vaccines made by Moderna and Pfizer-BioNTech are based on messenger RNA, while the Johnson and Johnson vaccine uses viral vectors. The ability to receive initial vaccinations using one approach, followed by a booster that uses the other approach offers an expanded range of possibilities,” said Karen Kotloff, MD, Professor of Pediatrics, Associate Director for Clinical Research in CVD, and principal investigator of the UMSOM VTEU. “For example, when supplies are short, or people have side effects to one type of vaccine, having this flexibility can be very important. This study provides reassurance that mixing and matching vaccines is a feasible approach that is well-tolerated and triggers strong immune responses.”
The trial participants kept diaries of any side effects and supplied blood samples on the day of booster vaccination and 15 days after boost. More than half of participants reported mild/moderate headache, pain at the injection site, muscle aches, and malaise, which was similar to the primary series. There were no vaccine-related serious adverse events reported.
Study participants will be followed for a year to assess longer-term immune responses. Additional COVID-19 vaccine candidates will be studied in the future.
“We are fortunate to have some of the top vaccine scientists in the world in our Center for Vaccine Development and Global Health – such as Dr. Lyke – leading the way in COVID-19 vaccine research throughout the pandemic,” said E. Albert Reece, MD, PhD, MBA, Executive Vice President for Medical Affairs, UM Baltimore, and the John Z. and Akiko K. Bowers Distinguished Professor and Dean at UMSOM. “As we confront another variant of COVID-19 – this one the most contagious of all – the availability of the mix-and-match booster approach came just in time for successive waves of the Delta and Omicron variants and likely contributed to saving many lives.”
NIAID grants supporting this research are UM1AI48372, UM1AI148373, UM1AI148450, UM1AI148452, UM1AI148573, UM1AI148574, UM1AI148575, UM1AI148576, UM1AI148684, UM1 AI148689 and with support from the NIAID Collaborative Influenza Vaccine Innovation Centers (CIVICs) contract 75N93019C00050.
About the University of Maryland School of Medicine
Now in its third century, the University of Maryland School of Medicine was chartered in 1807 as the first public medical school in the United States. It continues today as one of the fastest growing, top-tier biomedical research enterprises in the world -- with 46 academic departments, centers, institutes, and programs, and a faculty of more than 3,000 physicians, scientists, and allied health professionals, including members of the National Academy of Medicine and the National Academy of Sciences, and a distinguished two-time winner of the Albert E. Lasker Award in Medical Research. With an operating budget of more than $1.2 billion, the School of Medicine works closely in partnership with the University of Maryland Medical Center and Medical System to provide research-intensive, academic and clinically based care for nearly 2 million patients each year. The School of Medicine has nearly $600 million in extramural funding, with most of its academic departments highly ranked among all medical schools in the nation in research funding. As one of the seven professional schools that make up the University of Maryland, Baltimore campus, the School of Medicine has a total population of nearly 9,000 faculty and staff, including 2,500 students, trainees, residents, and fellows. The combined School of Medicine and Medical System (“University of Maryland Medicine”) has an annual budget of over $6 billion and an economic impact of nearly $20 billion on the state and local community. The School of Medicine, which ranks as the 8th highest among public medical schools in research productivity (according to the Association of American Medical Colleges profile) is an innovator in translational medicine, with 606 active patents and 52 start-up companies. In the latest U.S. News & World Report ranking of the Best Medical Schools, published in 2021, the UM School of Medicine is ranked #9 among the 92 public medical schools in the U.S., and in the top 15 percent (#27) of all 192 public and private U.S. medical schools. The School of Medicine works locally, nationally, and globally, with research and treatment facilities in 36 countries around the world. Visit medschool.umaryland.edu
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