Curated News: NEJM

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Updated results from a phase 3 clinical trial are expected to change the way advanced stage classic Hodgkin lymphoma (cHL) is treated. Details appear in a study published today in The New England Journal of Medicine. Drs. Kara Kelly of Roswell Park Comprehensive Cancer Center and Sharon Castellino of Children’s Healthcare of Atlanta and Emory University School of Medicine/Winship Cancer Institute of Emory University served as pediatric leads of this important trial in children and adults with lymphoma.

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According to findings from a multicenter study led by Johns Hopkins Medicine and released today in The New England Journal of Medicine (NEJM), transplanting kidneys from deceased donors who had the human immunodeficiency virus (HIV) to recipients with HIV is safe. Perhaps more importantly, the study authors also found that HIV-to-HIV kidney transplants are comparable in effectiveness to those using organs from donors without HIV.

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A new systematic review led by researchers in Hamilton, Canada has shown that specialized in-bed cycling therapy, when used in the intensive care unit with critically ill patients, leads to better physical function and a one-day shorter length of stay in the ICU.

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An international placebo-controlled study led by Cedars-Sinai suggests that a targeted drug therapy that was developed by researchers at Cedars-Sinai is safe and effective at helping people with moderate to severe ulcerative colitis reach clinical remission.

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CLEVELAND: A clinical trial has demonstrated that the cancer drug pomalidomide is safe and effective in treating hereditary hemorrhagic telangiectasia (HHT), a rare bleeding disorder that impacts more than 1 in 5,000 people worldwide.

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Avian influenza A(H5N1) virus, which spread to cattle and infected 14 people this year, was detected using virome sequencing in the wastewater of 10 Texas cities by researchers at UTHealth Houston and Baylor College of Medicine.

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A brain-computer interface developed by UC Davis Health accurately translates brain signals into speech. The device implanted in the brain of a man with ALS is the most accurate system of its kind.

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A new drug for treatment of a type of brain cancer, called IDH-mutant low-grade glioma, was approved Aug. 6 by the U.S. Food and Drug Administration (FDA). The promising new drug stems from a 2008 genetic discovery made at the Johns Hopkins Kimmel Cancer Center.

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When it comes to caring for children with congenital adrenal hyperplasia (CAH), avoiding the side effects of traditional treatments has long been a challenge. But in a recent phase 3 clinical trial, a new drug called crinecerfont showed safety and efficacy in children with classic CAH, the severe form of this condition.

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En un nuevo estudio multicéntrico internacional dirigido por el Centro Oncológico Integral de Mayo Clinic, investigadores encontraron que las personas con el subtipo de leucemia linfoblástica aguda precursores de células B (LLA-BCP), que tampoco presentaban una anomalía genética conocida como cromosoma Filadelfia y que estaban en remisión y sin rastros de cáncer, mostraron tasas de supervivencia significativamente más altas cuando se agregó blinatumomab al tratamiento de quimioterapia.

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Em um novo estudo multicêntrico internacional liderado pelo Centro Oncológico Integral da Mayo Clinic, pesquisadores descobriram que pessoas com o subtipo de leucemia linfoblástica aguda de precursor de células B (LLA-BCP), que também não apresentavam uma anomalia genética conhecida como cromossomo Filadélfia e que estavam em remissão e sem vestígios de câncer, mostraram taxas de sobrevivência significativamente mais elevadas quando o blinatumomab foi adicionado ao tratamento quimioterápico.

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In a new multicenter international study led by the Mayo Clinic Comprehensive Cancer Center, researchers found that people with the B-cell precursor subtype of acute lymphoblastic leukemia (BCP-ALL), who also lacked a genetic abnormality known as the Philadelphia chromosome and were in remission with no trace of cancer, showed significantly higher survival rates when blinatumomab was added to their chemotherapy treatment.

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The risk of long COVID has declined over the course of the pandemic, although it remains a persistent threat. Researchers from Washington University School of Medicine in St. Louis identified vaccination as a primary factor in reducing the risk of long COVID.

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Bakris served on the UChicago faculty for 18 years and was director of the Comprehensive Hypertension Center.

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The data fed to artificial intelligence (AI) systems make all the difference on performance, according to David Ouyang, MD, a cardiologist in the Department of Cardiology in the Smidt Heart Institute at Cedars-Sinai.

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Patients with moderate to severe treatment-resistant depression (TRD) might have better symptom relief from ketamine infusions than from electroconvulsive therapy (ECT), but those with severe TRD could benefit more from ECT early in treatment, an analysis led by a UT Southwestern Medical Center researcher shows. The findings, published in JAMA Network Open, are the first to identify characteristics that distinguish which treatments might benefit TRD patients more.