Scientists at St. Jude Childrenâs Research Hospital explored selectively blocking the CYP3A4 protein responsible for breaking down large swaths of approved drugs, providing a way to improve drug efficacy.
Scientists at St. Jude Childrenâs Research Hospital used a series of cryo-EM structures to visualize dynamics pivotal to chromatin remodeling, a process implicated in cancer and developmental disorders.
A collaborative research effort in global childhood cancer has revealed the significant negative impact of living in regions of armed conflict on pediatric cancer outcomes.
Find how a mitochondrial protein protects cancer cells from immunotherapy, giving scientists a new target type to improve solid tumor treatment & save lives.
Existing antivirals may be less effective against this H5N1 bird flu strain, and prevention measures, such as avoiding raw milk consumption and reducing exposure in dairy workers, may be the most effective way to protect against the virus.
Spatial transcriptomics is a cutting-edge technique that characterizes gene expression within sections of tissue, such as heart, skin or liver tissue. Scientists at St. Jude and the University of Wisconsin-Madison today share a generative algorithm for achieving both high genome and image resolution.
Scientists at St. Jude Childrenâs Research Hospital used positron emission tomography (PET) with edaravone, a drug used to treat ALS, to detect oxidative stress, which leads to brain damage, offering a clear path to detecting neurological conditions.
Why retinoic acid is effective in this setting but not against primary tumors, has been speculated about for nearly 50 years. St. Jude Childrenâs Research Hospital scientists resolved the mystery, showing the drug âhijacksâ a normal developmental pathway to trigger cancer cell death.
Scientists at St. Jude Childrenâs Research Hospital report results from a promising new approach to treat the rare neurodegenerative disorder.
Cancer researchers in Seattle, San Francisco, Boston, New York and Memphis were selected as Pediatric Fellows, each of whom will receive funding for four years ($300,000 total) to support an innovative research project related to the diagnosis or treatment of one or more pediatric cancers.
Dr. Schwarz was nominated for PECASE by the National Institute of Neurological Disorders and Stroke (NINDS), part of the National Institutes of Health (NIH), based in part on her development of a tool for improving the ease and accuracy of studying and manipulating specific subpopulations of cells.
Her newly formed department will establish a community of technology innovators at St. Jude, whose tools and techniques will accelerate scientific discovery and improve the understanding and diagnosis of catastrophic childhood diseases.
Scientists at St. Jude Childrenâs Research Hospital have uncovered the intricate circuit cues behind neuronal cell maturation and migration, which is required for proper cognitive function.
St. Jude bioinformaticists created a machine-learning algorithm capable of scaling with these single-cell data repositories to deliver more accurate results. Published in Cell Genomics.
Scientists at St. Jude Childrenâs Research Hospital traced connectivity between neurons to identify how the brain communicates with the spinal cord to control motor function.
Scientists at St. Jude Childrenâs Research Hospital leveraged fundamental features of chemical building blocks to transform chemical reaction analysis from minutes to milliseconds.
Medgal will oversee departments vital to St. Jude operations. She previously led operations at major cancer centers in Boston and New York.
Scientists at St. Jude Childrenâs Research Hospital identified skull deformation as a potential culprit for causing symptoms of 22q11.2 deletion syndrome.
Scientists at St. Jude Childrenâs Research Hospital identified a panel of 27 proteins that could accurately predict treatment-related cardiomyopathy risk among childhood cancer survivors.
Georgios Skiniotis, PhD, to develop and lead new center focusing on advanced imaging techniques, including cryo-ET.
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