Latest news from St. Jude Children's Research Hospital on Newswise en-us Copyright 2024 Newswise 115 31 / /images/newswise-logo-rss.gif /articles/urate-transporter-structures-reveal-the-mechanism-behind-important-drug-target-for-gout/?sc=rsin /articles/urate-transporter-structures-reveal-the-mechanism-behind-important-drug-target-for-gout/?sc=rsin Mon, 09 Sep 2024 11:05:22 EST Ten structures of URAT1 obtained by scientists at St. Jude Children's Research Hospital provide a deep understanding of the mechanism of urate transport to guide gout therapeutic design. St. Jude Children's Research Hospital /articles/early-interventions-may-improve-long-term-academic-achievement-in-young-childhood-brain-tumor-survivors/?sc=rsin /articles/early-interventions-may-improve-long-term-academic-achievement-in-young-childhood-brain-tumor-survivors/?sc=rsin Wed, 21 Aug 2024 12:05:25 EST Scientists at St. Jude Children's Research Hospital found infants and young children treated for brain tumors fell behind early in academic readiness, which predicted falling behind in later school years. St. Jude Children's Research Hospital /articles/t-helper-cells-may-be-the-key-to-improving-annual-influenza-vaccines/?sc=rsin /articles/t-helper-cells-may-be-the-key-to-improving-annual-influenza-vaccines/?sc=rsin Tue, 20 Aug 2024 10:05:28 EST The annual influenza vaccination provides updated protection against the virus but could be improved as there is large variability in its efficacy. St. Jude Children's Research Hospital /articles/study-reveals-oleoyl-acp-hydrolase-underpins-lethal-respiratory-viral-disease/?sc=rsin /articles/study-reveals-oleoyl-acp-hydrolase-underpins-lethal-respiratory-viral-disease/?sc=rsin Mon, 12 Aug 2024 13:30:50 EST Respiratory infections can be severe, even deadly, in some individuals, but not in others. Scientists at St. Jude Children's Research Hospital, the Peter Doherty Institute for Infection and Immunity and other collaborators have gained new understanding of why this is the case by uncovering an early molecular driver that underpins fatal disease. St. Jude Children's Research Hospital /articles/scientists-identify-genes-linked-to-relapse-in-the-most-common-form-of-childhood-leukemia/?sc=rsin /articles/scientists-identify-genes-linked-to-relapse-in-the-most-common-form-of-childhood-leukemia/?sc=rsin Mon, 12 Aug 2024 11:50:31 EST Scientists from St. Jude Children's Research Hospital, Seattle Children's and the Children's Oncology Group (COG) have identified novel genetic variations that influence relapse risk in children with standard risk B-cell acute lymphoblastic leukemia (SR B-ALL), the most common childhood cancer. St. Jude Children's Research Hospital /articles/st-jude-identifies-sars-cov-2-mimic-contributing-to-pediatric-inflammatory-syndrome/?sc=rsin /articles/st-jude-identifies-sars-cov-2-mimic-contributing-to-pediatric-inflammatory-syndrome/?sc=rsin Wed, 07 Aug 2024 13:05:07 EST Discover St. Jude research from Paul Thomas, PhD, linking SARS-CoV-2 infections and molecular mimicry with multisystem inflammatory syndrome in children. St. Jude Children's Research Hospital /articles/genetic-episignatures-guide-researchers-in-identifying-causes-of-unsolved-epileptic-neurological-disorders/?sc=rsin /articles/genetic-episignatures-guide-researchers-in-identifying-causes-of-unsolved-epileptic-neurological-disorders/?sc=rsin Tue, 06 Aug 2024 15:05:51 EST Scientists at St. Jude Children's Research Hospital use DNA methylation patterns as a roadmap for identifying causes of severe epilepsies in children. St. Jude Children's Research Hospital /articles/age-impacts-pharmacogenomics-and-treatment-outcomes-for-most-common-form-of-leukemia/?sc=rsin /articles/age-impacts-pharmacogenomics-and-treatment-outcomes-for-most-common-form-of-leukemia/?sc=rsin Mon, 05 Aug 2024 17:05:57 EST Explore how scientists at St. Jude Children's Research Hospital have identified causes for age-related differences in treatment outcomes of B-cell acute lymphoblastic leukemia. St. Jude Children's Research Hospital /articles/improved-chemokine-homing-enhances-car-t-cell-therapy-for-osteosarcoma/?sc=rsin /articles/improved-chemokine-homing-enhances-car-t-cell-therapy-for-osteosarcoma/?sc=rsin Mon, 05 Aug 2024 12:05:38 EST Learn how scientists at St. Jude are leading research to improve CAR T-cell therapy for osteosarcoma by enhancing chemokine homing. St. Jude Children's Research Hospital /articles/serotonin-uptake-regulates-ependymoma-tumor-growth/?sc=rsin /articles/serotonin-uptake-regulates-ependymoma-tumor-growth/?sc=rsin Wed, 31 Jul 2024 14:05:46 EST St. Jude Children's Research Hospital and Baylor College of Medicine have implicated the neurotransmitter serotonin in ependymoma tumor growth, suggesting a new class of drugs to test against these tumors. St. Jude Children's Research Hospital /articles/biomolecular-condensate-molecular-putty-properties-found-encoded-in-protein-sequence/?sc=rsin /articles/biomolecular-condensate-molecular-putty-properties-found-encoded-in-protein-sequence/?sc=rsin Tue, 02 Jul 2024 12:05:02 EST Scientists at St. Jude Children's Research Hospital, the State University of New York at Buffalo and Washington University at St. Louis probed how condensates behave like viscoelastic putty and age to more solid states. St. Jude Children's Research Hospital /articles/master-autoimmune-regulator-gets-by-with-a-little-help-from-its-friends/?sc=rsin /articles/master-autoimmune-regulator-gets-by-with-a-little-help-from-its-friends/?sc=rsin Thu, 27 Jun 2024 13:05:46 EST See how St. Jude researchers investigated Foxp3 function as a transcription cofactor in regulatory T cells in immune system activation and suppression. St. Jude Children's Research Hospital /articles/children-genetically-prone-to-cancer-benefit-from-early-standardized-surveillance/?sc=rsin /articles/children-genetically-prone-to-cancer-benefit-from-early-standardized-surveillance/?sc=rsin Thu, 20 Jun 2024 12:05:21 EST Scientists at St. Jude Children's Research Hospital found that, with early screening, they could detect new cancers in pediatric patients with an underlying genetic predisposition at their most treatable stages. St. Jude Children's Research Hospital /articles/st-jude-scientists-solve-decades-long-mystery-of-nlrc5-sensor-function-in-cell-death/?sc=rsin /articles/st-jude-scientists-solve-decades-long-mystery-of-nlrc5-sensor-function-in-cell-death/?sc=rsin Fri, 14 Jun 2024 15:40:53 EST Learn about immunology research from the St. Jude laboratory of Thirumala-Devi Kanneganti, PhD, that revealed the function of the NLRC5 innate immune sensor.  St. Jude Children's Research Hospital /articles/novel-insights-into-fluorescent-dark-states-illuminate-ways-forward-for-improved-imaging/?sc=rsin /articles/novel-insights-into-fluorescent-dark-states-illuminate-ways-forward-for-improved-imaging/?sc=rsin Fri, 14 Jun 2024 12:05:08 EST St. Jude Children's Research Hospital scientists address decades-long problem in the field of single-molecule fluorescence resonance energy transfer, paving the way for more accurate experiments. St. Jude Children's Research Hospital /articles/age-is-just-a-number-immune-cell-epigenetic-clock-ticks-independently-of-organism-lifespan/?sc=rsin /articles/age-is-just-a-number-immune-cell-epigenetic-clock-ticks-independently-of-organism-lifespan/?sc=rsin Wed, 12 Jun 2024 10:50:14 EST See how St. Jude researchers use epigenetic clock, DNA methylation and mouse model to demonstrate that T cell proliferation can stretch past organism lifespan and acuta lymphoblastic leukemia T cells appear hundreds of years old. St. Jude Children's Research Hospital /articles/cell-targeting-technology-allows-researchers-to-isolate-neuronal-subpopulations-and-link-them-to-behavioral-states/?sc=rsin /articles/cell-targeting-technology-allows-researchers-to-isolate-neuronal-subpopulations-and-link-them-to-behavioral-states/?sc=rsin Tue, 28 May 2024 12:05:54 EST Scientists at St. Jude Children's Research Hospital designed an intersectional technique for precisely targeting subpopulations of cells and parsing out specific functions. St. Jude Children's Research Hospital /articles/repurposed-protease-controls-important-signaling-molecule-activating-protein/?sc=rsin /articles/repurposed-protease-controls-important-signaling-molecule-activating-protein/?sc=rsin Wed, 22 May 2024 11:05:39 EST Scientists at St. Jude Children's Research Hospital reveal the role of iRhom2's defunct protein-cleaving domain in lifecycle of ADAM17, a key signaling molecule-activating protein. St. Jude Children's Research Hospital /articles/novel-inhibitor-insights-offer-pathway-to-preventing-pxr-associated-drug-resistance/?sc=rsin /articles/novel-inhibitor-insights-offer-pathway-to-preventing-pxr-associated-drug-resistance/?sc=rsin Tue, 14 May 2024 16:05:30 EST Scientists at St. Jude Children's Research Hospital uncovered a route to blocking activity of protein notorious for eliminating drugs, offering a potential boon to cancer therapy. St. Jude Children's Research Hospital /articles/hongbo-chi-phd-named-2023-aaas-fellow/?sc=rsin /articles/hongbo-chi-phd-named-2023-aaas-fellow/?sc=rsin Mon, 29 Apr 2024 13:05:00 EST Hongbo Chi, PhD, a faculty member and the Robert G. Webster Endowed Chair in Immunology at St. Jude Children's Research Hospital, has been recognized as a fellow of the American Association for the Advancement of Science (AAAS), the world's largest general scientific society and publisher of the Science Family of Journals. St. Jude Children's Research Hospital