Curated News: Nature (journal)

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A drug that delivers chemotherapy directly to tumors has shown impressive activity against some of the hardest-to-reach cancer cells: those that have spread to the brain in patients with advanced HER2-positive breast cancer. Research led by Dana-Farber Cancer Institute.

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In a new study, researchers have determined through both statistical analysis and in experiments that soil pH is a driver of microbial community composition – but that the need to address toxicity released during nitrogen cycling ultimately shapes the final microbial community.

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Mayo Clinic researchers mined the molecular foundations of cancer and uncovered a new reason chimeric antigen receptor (CAR-T cell therapy) fails in some patients. This discovery has fueled new strategies that incorporate antibodies and gene editing to improve the outcome of this breakthrough treatment for patients.

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In a study of 12 participants, researchers at Beth Israel Deaconess Medical Center (BIDMC) have demonstrated that a cocktail of three broadly neutralizing antibodies (bNAb) successfully suppressed virus in people living with HIV. A subset of participants also demonstrated long-term control of the virus months after antibody levels declined to low or undetectable.

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A protein called torsinA plays a key role in the early development of neurons, determining where nuclear pores are placed in the membrane that encloses the nucleus of nerve cells, a study led by UT Southwestern Medical Center researchers shows.

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Uma equipe de pesquisadores da Mayo Clinic desenvolveu uma ferramenta computacional inovadora que analisa o microbioma intestinal, um ecossistema complexo de trilhões de bactérias, fungos, vírus e outros microorganismos dentro do sistema digestivo, para fornecer informações sobre o bem-estar geral do indivíduo.

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An Iowa State University research team has discovered when and why inflammatory signaling affects the formation of blood stem cells in embryos, which will benefit efforts to develop lab-grown, patient-derived stem cell transfusions to treat blood disorders. The promising advancement in regenerative medicine could eliminate the need for bone marrow transplants.

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Researchers at the University of Michigan Health Rogel Cancer Center have uncovered a key reason why a typically normal protein goes awry and fuels cancer. They found the protein NSD2 alters the function of the androgen receptor, an important regulator of normal prostate development.

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Researchers from the Nevada Center for Astrophysics at UNLV have discovered compelling evidence suggesting that the supermassive black hole at the center of our Milky Way galaxy, known as Sagittarius A* (Sgr A*), is likely the result of a past cosmic merger. The study, published Sept. 6 in the journal Nature Astronomy, builds on recent observations from the Event Horizon Telescope, which captured the first direct image of Sgr A* in 2022.

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New findings from a global team of expert scientists in academia and industry has generated world-first research quality standards that will help slash costs and reduce the time it takes to develop advanced nanomedicine treatments and make them available for patients.

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Experiment findings will help nuclear industry model, design and construct clean nuclear energy systems, and continue an impressive safety legacy.

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Physical human feats require a high level of coordination between the sensory functions of our skin and motor functions of our muscles. What kind of achievements could robots perform with the same cohesion between sensing and action? In the medical space, researchers have begun to explore the possibilities.

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Alexander Chase and colleagues collect samples from Earth’s oceans using SMIRC, which could be the first step in uncovering compounds that lead to next-generation antibiotics.

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Various forms of arthritis afflict nearly 600 million people worldwide and add $16.5 billion to the United States’ healthcare bill, yet there are few engineered cartilage tissue therapies available to sufferers. In Nature Reviews Rheumatology, University of California, Irvine biomedical engineers shared insights into the effective treatment of severe osteoarthritis and rheumatoid arthritis and the clinical trial and regulatory efforts that are going to be necessary to bring products to market.

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Investigators involved in a multicenter study co-led by Cedars-Sinai discovered a pathway by which immune cells prevent the lungs’ protective barrier from healing after viral infections like COVID-19. The findings, published in Nature, may lead to new therapeutic treatment options.

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Immune checkpoint inhibitors are a type of cancer treatment that helps the immune system attack cancer cells more effectively. One of the key proteins involved in this process is Lymphocyte Activation Gene-3 (LAG3), which suppresses the antitumor immune response.

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The new approach marks a major step forward in the design of AI tools to support clinical decisions in cancer diagnosis, therapy. The model uses features of a tumor’s microenvironment to forecast how a patient might respond to therapy and to help inform individualized treatments.

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WashU Medicine researchers have designed, in mice, an approach to minimizing the damage from a spinal cord injury through the use of engineered immune cells. Mice given the treatment had improved recovery from injuries, demonstrating potential for developing the therapy for people.

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In 2D quantum materials, chiral edge states are 1D conducting channels in which electrons travel only in one direction and electron collisions are strongly suppressed. This means chiral channels act like resistance-free conductors.