Researchers have for the first time identified degeneration-associated “molecular markers” – observable changes in cells and their gene-regulating networks – that are shared by several forms of dementia that affect different regions of the brain.
Violent blows or jolts to the head can cause traumatic brain injury (TBI), and there are currently about five million people in the U.S. living with chronic neurodegeneration and related impairments due to TBI.
Using cutting-edge bioinformatics techniques for gene identification and sequencing, researchers at UCLA are comprehensively map signaling pathway distributions in both normal and acne-affected skin.
Cancer cells appear to hijack a genetic pathway involved in DNA repair to drive malignancy and overcome treatment, a study led by UT Southwestern Medical Center researchers shows. Their findings, published in Cell, explain how chromosomes in some tumors undergo massive rearrangements and could lead to new strategies to avoid cancer drug resistance.
Ten structures of URAT1 obtained by scientists at St. Jude Children’s Research Hospital provide a deep understanding of the mechanism of urate transport to guide gout therapeutic design.
MSK researchers have identified two signaling pathways that work together to spur the spread of lung cancer. Taking away one of those signals could help slow or stop metastasis, findings in animal models suggest.
Age-related changes in the fibroblasts, cells that create the skin’s structure, contribute to the development of aggressive, treatment-resistant melanoma in males, according to research in mice by the Johns Hopkins Kimmel Cancer Center.
Using a new workflow that integrates spatial transcriptomics and machine learning for imaging analysis and integration with single-cell datasets, researchers at the Johns Hopkins Kimmel Cancer Center have identified novel molecular and cellular markers in the development of one of the most aggressive, deadly pancreatic cancers: pancreatic ductal adenocarcinoma (PDAC).
Scientists who have described in a new study the step-by-step details of a bacterial defense strategy see the mechanism as a promising platform for development of a new genome-editing method.
Rutgers University-New Brunswick scientists have discovered a virus that caused a nationwide die-off of superworms, a common food for birds, reptiles, other pets and, more and more so, even for humans as an alternative protein source. In doing so, they pioneered a different way to search for and identify emerging viruses and pathogens in humans, plants and animals.
Scientists at La Jolla Institute for Immunology (LJI) are investigating how the mutated clade 1 mpox virus may affect children and older patients—and how new vaccines can help the body fight back.
Research in mice sheds light on how thyroid hormone alters wiring in the brain. Findings reveal that thyroid hormone syncs up the brain and body to drive exploratory behavior. Researchers say their work could illuminate new treatments for certain psychiatric conditions.
Dr. Alice Soragni and her team developed a high throughput organoid screening platform to rapidly establish and screen 3D tumor organoids for cutaneous neurofibromas to find drugs that slow tumor growth.
An Indiana University School of Medicine physician scientist is making strides in understanding the molecular origins of fatty liver disease, a leading cause of liver failure in the United States.
Respiratory infections can be severe, even deadly, in some individuals, but not in others. Scientists at St. Jude Children’s Research Hospital, the Peter Doherty Institute for Infection and Immunity and other collaborators have gained new understanding of why this is the case by uncovering an early molecular driver that underpins fatal disease.
Working with human stem cells that form a kind of “mini intestine-in-a-dish,” Johns Hopkins Medicine scientists say they have found several molecular mechanisms for COVID-19-related diarrhea, suggesting potential ways to control it.
A new study identifies and validates a 10-gene biomarker that potentially predicts whether a stage II or III colon cancer patient will benefit from adjuvant chemotherapy. A secondary finding from the study suggests that the gene signature could potentially also predict whether immunotherapy would help some patients.
A new paper surveying advances in diabetes pathogenesis and treatment explores the complex factors contributing to the onset and progression of the disease, suggesting that an understanding of these dynamics is key to developing targeted interventions to reduce the risk of developing diabetes and managing its complications.
Earth’s atmosphere holds an ocean of fresh water. Extracting some of that moisture is seen as a potential way to provide clean drinking water to billions of people globally who face chronic shortages. A prototype device developed by University of Utah engineers for the U.S. Army harvests drinking water from atmosphere, even in arid places.
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