Newswise Curated News Channel: Cell (journal)

Using AI to Uncover Hospital Patients' Long COVID Care Needs

Perelman School of Medicine at the University of Pennsylvania — Fri, 10 Jan 2025 20:05:50 EST

A new machine learning technique could help inform clinical decision-making across hospital systems to address the challenges of long COVID-19 care.

Study Unveils 13 Genes That Increase Risk of Osteoarthritis

University of North Carolina School of Medicine — Wed, 08 Jan 2025 20:05:42 EST

A new study by researchers at the UNC Thurston Arthritis Research Center at the UNC School of Medicine has identified 13 risk genes that can increase chances for developing osteoarthritis, jumpstarting research that could lead to new, targeted treatments.

Cedars-Sinai, UCSF Experts Steer the Development of Stem Cells to Regenerate and Repair Organs

Cedars-Sinai — Thu, 19 Dec 2024 21:00:34 EST

Investigators from Cedars-Sinai and the University of California, San Francisco (UCSF) have identified a new way to deliver instructions that tell stem cells to grow into specific bodily structures, a critical step in eventually regenerating and repairing tissues and organs.

MSK Research Highlights, December 18, 2024

Memorial Sloan Kettering Cancer Center — Wed, 18 Dec 2024 19:00:00 EST

New research from Memorial Sloan Kettering Cancer Center (MSK) uncovers clues about how cells control a key DNA repair protein; develops a new method for studying gene amplifications in cancer; sheds new light on tumor suppressor genes; shows MSK-IMPACT(r) could be used for HLA genotype screening to predict response to cellular therapies; identifies a possible strategy to overcome immune evasion in ovarian cancer; and finds strong support for telemedicine visits among cancer patients.

Researchers Identify Key Driver of Fibrosis in Crohn's Disease

University of North Carolina School of Medicine — Wed, 18 Dec 2024 18:55:36 EST

Researchers at the UNC School of Medicine have found a key process by which gut bacteria may be contributing to intestinal fibrosis, a major complication of an intestinal inflammatory disease called Crohn's disease.

Researchers Create Gene Therapy with Potential to Treat Peripheral Pain Conditions

University of North Carolina School of Medicine — Tue, 17 Dec 2024 22:00:07 EST

Researchers at the UNC School of Medicine have engineered a molecular technology that can turn off pain receptors.

Neural Stem Cell Transplantation Shows Promise for Treating Chronic Spinal Cord Injury

University of California San Diego — Tue, 17 Dec 2024 09:00:05 EST

Genetic Data From 'Biobanks' May Help Improve Prediction of Effectiveness, Side Effects of Common Medications, Study Finds

University of California, Los Angeles (UCLA), Health Sciences — Wed, 04 Dec 2024 12:25:41 EST

A UCLA study has outlined a new framework that researchers say would improve predictive power of genetics to determine how well a patient would respond to commonly prescribed medications as well as the severity of any side effects.

New Technology Points to Unexpected Uses for snoRNA

University of Chicago Biological Sciences Division — Fri, 22 Nov 2024 11:00:00 EST

Researchers from the University of Chicago recently developed a new approach for identifying new cellular RNA targets of snoRNAs. They uncovered thousands of previously unknown targets for snoRNAs in human cells and mouse brain tissues, including many that serve functions other than guiding rRNA modifications.

New Discovery May Lead to More Effective Treatment for Cardiovascular Disease

Case Western Reserve University — Wed, 13 Nov 2024 09:00:12 EST

Researchers at Case Western Reserve University have identified a new target to treat atherosclerosis, a condition where plaque clogs arteries and causes major cardiac issues, including stroke and heart attack.

A Newly Developed Algorithm Shows How a Gene Is Expressed at Microscopic Resolution

Michigan Medicine - University of Michigan — Thu, 31 Oct 2024 13:50:05 EST

A new method developed by University of Michigan researchers creates images that are worth many gigabytes of data, which could revolutionize the way biologists study gene expression.

Study Identifies How Ovarian Cancer Protects Itself, Paves Way for Improved Immunotherapy Approach

Mount Sinai Health System — Wed, 30 Oct 2024 11:00:00 EST

Researchers at the Icahn School of Medicine at Mount Sinai have discovered a way that ovarian cancer tumors manipulate their environment to resist immunotherapy and identified a drug target that could overcome that resistance. The study, published in the October 30 online issue of Cell used a cutting-edge spatial genomics technology and preclinical animal models, with tumor specimens from ovarian cancer patients further validating the findings. They found that ovarian cancer cells produce a molecule called Interleukin-4 (IL-4), which is typically associated with asthma and the skin condition eczema, also known as atopic dermatitis. The study went on to find that the cancer cells used IL-4 to create a protective environment that kept away killer immune cells, making the tumors resistant to immunotherapy. A drug, dupilumab, which blocks IL-4's activity, has been approved by the Food and Drug Administration (FDA) and is already used to treat asthma and eczema. This new study suggests dupi

A New Chemistry for CRISPR

Rockefeller University — Mon, 28 Oct 2024 12:30:10 EST

It acts as a sort of molecular fumigator to battle phages and plasmids.

New Research Offers Hope for Treating Inherited Peripheral Neuropathies

Uniformed Services University of the Health Sciences (USU) — Tue, 22 Oct 2024 12:10:09 EST

A recent study published by Dr. Jordan Verplank, Assistant Professor in the Department of Anatomy, Physiology, and Genetics at the Uniformed Services University of the Health Sciences (USU), and a team of scientists from USU, State University of Buffalo (New York), and Cyclerion Therapeutics, has identified a promising approach for treating hereditary peripheral neuropathies, specifically Charcot Marie Tooth disease types 1A (CMT1A) and 1B (CMT1B). By focusing on increasing levels of cyclic guanosine monophosphate (cGMP) - a signaling molecule involved in various biological processes - the study has shown potential improvements in myelination, nerve conduction, and motor coordination in mouse models affected by these conditions. The findings were published in Cellular and Molecular Life Sciences on October 14, 2024.

Researchers Help Redefine Core Microbiome, Opening New Chapter in Precision Health

Rutgers University-New Brunswick — Wed, 16 Oct 2024 12:25:33 EST

Researchers at Rutgers University-New Brunswick, along with international collaborators, have introduced a novel method for identifying the crucial set of gut microbes commonly found in humans and essential for health.

Study Explores Novel Therapeutic Treatment for Glioblastoma

Ohio State University Wexner Medical Center — Mon, 07 Oct 2024 15:05:53 EST

Researchers with The Ohio State University Comprehensive Cancer Center - Arthur G. James and Richard J. Solove Research Institute are trying to improve outcomes for patients with a deadly form of brain cancer known as glioblastoma.

Scientists Discover That Special Immune Cells Stop Metastatic Cancer

Montefiore Einstein Comprehensive Cancer Center — Mon, 07 Oct 2024 11:00:00 EST

A research team at the National Cancer Institute-designated Montefiore Einstein Comprehensive Cancer Center (MECCC) has discovered a natural immune mechanism in mice that stops escaped cancer cells from developing into tumors elsewhere in the body. The findings were published today in the journal Cell.

Moffitt Study Unveils the Role of Gamma-Delta T Cells in Cancer Immunology

Moffitt Cancer Center — Fri, 04 Oct 2024 12:00:07 EST

TAMPA, Fla. - A new study published in Cell Press reveals critical insights into the role of gamma-delta T cells across 33 cancer types, shedding light on their potential as clinical biomarkers and therapeutic targets in cancer treatment. Led by a team of researchers at Moffitt Cancer Center, this comprehensive analysis represents a significant advancement in the understanding of these unique immune cells and their implications for patient outcomes in cancer therapy.

Research Points to Potential New Treatment for Aggressive Prostate Cancer Subtype

Michigan Medicine - University of Michigan — Fri, 04 Oct 2024 11:00:00 EST

In two new papers, both published in Cell Reports Medicine, researchers from the University of Michigan Rogel Cancer Center describe the mechanisms of how alterations in the CDK12 gene drive prostate cancer development and report on a promising degrader that targets CDK12 and a related gene to destroy tumors.

New Barcode Technology Could Help Diagnose Cancer More Precisely

Yale Cancer Center/Smilow Cancer Hospital — Mon, 30 Sep 2024 11:05:51 EST

A new pathology tool created at Yale harnesses barcode technology and shows potential for use in cancer diagnoses. The technology, Patho-DBiT (pathology-compatible deterministic barcoding in tissue), was discussed in a new study that published Sept. 30 in the journal Cell. Co-corresponding author Dr. Mina Xu, a Yale Cancer Center (YCC) member, professor of pathology at Yale School of Medicine (YSM), and the YSM director of hematopathology, shared her enthusiasm for the new tool.