Newswise Curated News Channel: Cell (journal)

LJI scientists lead new mpox research

La Jolla Institute for Immunology — Thu, 22 Aug 2024 13:05:32 EST

Scientists at La Jolla Institute for Immunology (LJI) are investigating how the mutated clade 1 mpox virus may affect children and older patients--and how new vaccines can help the body fight back.

How Thyroid Hormone Fuels the Drive to Explore

Harvard Medical School — Thu, 22 Aug 2024 11:00:00 EST

Research in mice sheds light on how thyroid hormone alters wiring in the brain. Findings reveal that thyroid hormone syncs up the brain and body to drive exploratory behavior. Researchers say their work could illuminate new treatments for certain psychiatric conditions.

Finding new treatments for genetic tumor-predisposition syndrome

University of California, Los Angeles (UCLA), Health Sciences — Wed, 21 Aug 2024 10:05:43 EST

Dr. Alice Soragni and her team developed a high throughput organoid screening platform to rapidly establish and screen 3D tumor organoids for cutaneous neurofibromas to find drugs that slow tumor growth.

New research explores the urea cycle's strong connection to fatty liver disease

Indiana University — Wed, 14 Aug 2024 08:00:32 EST

An Indiana University School of Medicine physician scientist is making strides in understanding the molecular origins of fatty liver disease, a leading cause of liver failure in the United States.

Study reveals oleoyl-ACP-hydrolase underpins lethal respiratory viral disease

St. Jude Children's Research Hospital — Mon, 12 Aug 2024 13:30:50 EST

Respiratory infections can be severe, even deadly, in some individuals, but not in others. Scientists at St. Jude Children's Research Hospital, the Peter Doherty Institute for Infection and Immunity and other collaborators have gained new understanding of why this is the case by uncovering an early molecular driver that underpins fatal disease.

Johns Hopkins Medicine Scientists Probe Molecular Cause of COVID-19 Related Diarrhea, Revealing Potential Treatments

Johns Hopkins Medicine — Tue, 06 Aug 2024 11:00:02 EST

Working with human stem cells that form a kind of "mini intestine-in-a-dish," Johns Hopkins Medicine scientists say they have found several molecular mechanisms for COVID-19-related diarrhea, suggesting potential ways to control it.

Study Identifies Biomarker that Could Predict Whether Colon Cancer Patients Benefit from Chemotherapy

Sylvester Comprehensive Cancer Center — Fri, 26 Jul 2024 16:05:45 EST

A new study identifies and validates a 10-gene biomarker that potentially predicts whether a stage II or III colon cancer patient will benefit from adjuvant chemotherapy. A secondary finding from the study suggests that the gene signature could potentially also predict whether immunotherapy would help some patients.

Recent insights and advances in treatment and management show promise in stemming the growing prevalence of diabetes

University of California, Los Angeles (UCLA), Health Sciences — Fri, 26 Jul 2024 15:05:40 EST

A new paper surveying advances in diabetes pathogenesis and treatment explores the complex factors contributing to the onset and progression of the disease, suggesting that an understanding of these dynamics is key to developing targeted interventions to reduce the risk of developing diabetes and managing its complications.

Producing water out of thin air

University of Utah — Wed, 24 Jul 2024 13:05:28 EST

Earth's atmosphere holds an ocean of fresh water. Extracting some of that moisture is seen as a potential way to provide clean drinking water to billions of people globally who face chronic shortages. A prototype device developed by University of Utah engineers for the U.S. Army harvests drinking water from atmosphere, even in arid places.

Children's Research Institute at UT Southwestern discovers tumor growth fueled by nucleotide salvage

UT Southwestern Medical Center — Thu, 18 Jul 2024 10:05:06 EST

Cancer cells salvage purine nucleotides to fuel tumor growth, including purines in foods we eat, an important discovery with implications for cancer therapies from research by Children's Medical Center Research Institute at UT Southwestern published in Cell.

UTSW study identifies RNA molecule that regulates cellular aging

UT Southwestern Medical Center — Wed, 17 Jul 2024 10:05:48 EST

A team led by UT Southwestern Medical Center researchers has discovered a new way that cells regulate senescence, an irreversible end to cell division.

Study reveals dual role of protein in cancer treatment

University of California, Los Angeles (UCLA), Health Sciences — Mon, 15 Jul 2024 18:05:36 EST

The study, published in Cell Reports, reveals how IRF1 can both hinder and help the body's immune response to tumors, depending upon which cells the protein is found in.

Stem Cell-Derived Therapy Shows Promise Against Treatment-Resistant Liver Cancer

University of California San Diego — Tue, 09 Jul 2024 11:05:45 EST

Discover research from UC San Diego showing how stem cell-derived therapy, targeting treatment-resistant liver cancer through genetically modified NK cells, offers promising new avenues for immunotherapy.

Researchers find common immune system mechanism between pregnancy, cancer

Michigan Medicine - University of Michigan — Mon, 08 Jul 2024 14:05:17 EST

Researchers at the University of Michigan Rogel Cancer Center found that a molecular mechanism, shared in cancer and pregnancy, that suppresses the immune system. Block this mechanism, called B7-H4, and the immune system revs up to slow cancer's growth.

UV Radiation Damage Leads to Ribosome Roadblocks, Causing Early Skin Cell Death

Johns Hopkins Medicine — Tue, 02 Jul 2024 13:30:56 EST

In a recent study, researchers at Johns Hopkins Medicine suggest the cell's messenger RNA (mRNA) -- the major translator and regulator of genetic material -- along with a critical protein called ZAK, spur the cell's initial response to UV radiation damage and play a critical role in whether the cell lives or dies.

Revolutionizing Ovarian Cancer Treatment With Adaptive PARP Inhibitor Therapy

Moffitt Cancer Center — Wed, 26 Jun 2024 13:05:02 EST

A new study led by researchers at Moffitt Cancer Center introduces an adaptive therapy approach that could optimize PARP inhibitor maintenance therapy, offering a more personalized and potentially less toxic treatment option for patients. Their work is featured as the cover article of the June 19 issue of Cell Systems.

Pilot Study Provides 'Blueprint' for Evaluating Diet's Effect on Brain Health

Johns Hopkins Medicine — Tue, 25 Jun 2024 14:00:20 EST

Researchers from Johns Hopkins Medicine and the National Institutes of Health's National Institute on Aging say their study of 40 older adults with obesity and insulin resistance who were randomly assigned to either an intermittent fasting diet or a standard healthy diet approved by the U.S. Department of Agriculture (USDA) offers important clues about the potential benefits of both eating plans on brain health.

Exploring Our Sense of Touch from Every Angle

Harvard Medical School — Tue, 11 Jun 2024 17:05:35 EST

Harvard Medical School researchers are studying one of the most mysterious -- and most essential -- senses

New Research from GRF-funded Investigators Reports Discovery of New Type of Neuron in the Eye

Glaucoma Research Foundation — Tue, 11 Jun 2024 13:05:28 EST

The discovery of how intricate networks of blood vessels in the eye and brain are formed could inspire new treatments for glaucoma, diabetic retinopathy, and stroke.

Moffitt Study Reveals New Mechanism of Drug Resistance in Melanoma Leptomeningeal Disease

Moffitt Cancer Center — Tue, 11 Jun 2024 11:05:58 EST

Leptomeningeal disease is a rare but lethal complication faced by late-stage melanoma patients. It occurs when cancer cells spread to the membranes covering the brain and spinal cord, or the leptomeninges. This condition, which affects 5% to 8% of melanoma patients, often leads to rapid deterioration and is notoriously resistant to therapies. However, a new Moffitt Cancer Center study, published today in Cell Reports Medicine, uncovers the mechanisms that drive this drug resistance, offering new avenues for potential treatments.