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Scientists have provided new details about how proteins used to destroy bacteria and viruses may help treat Alzheimer's disease. Gunnar K. Gouras and colleagues provide new insights into how these proteins, called antibodies, reduce the main hallmarks of Alzheimer's disease and raise hopes for a vaccine against the disease.
Scientists have shown for the first time that a protein involved in the transfer of fat in the blood may also influence how fat cells store fat.
Scientists have provided new evidence that using more fish oil than vegetable oil in the diet decreases the formation of chemicals called prostanoids, which, when produced in excess, increase inflammation in various tissues and organs. The results may help in designing new anti-inflammatory drugs with fewer side effects than the ones currently available.
Scientists have discovered a new enzyme involved in the degradation of proteins inside cells, a process that helps eliminate or recycle proteins that are no longer needed. The new enzyme is very highly expressed in the testis, which could provide a new understanding of male fertility.
Scientists have provided new insight into how a gene is related to schizophrenia. In a study to be published in the Journal of Biological Chemistry, the scientists describe for the first time a genetic variation that causes a gene to be overexpressed in the human brain. These results may provide a new way to design better drugs to treat schizophrenia.
Scientists have shown that recently developed mouse breeds that mimic the symptoms of Alzheimer's disease may not be as effective as previously assumed. The scientists show in the August 24 issue of the Journal of Biological Chemistry that in some mouse breeds, drugs that had been shown to reduce levels of a toxic protein called amyloid beta had only minor or no effect on these mice.
Researchers report the most complete list so far of proteins present in the human amniotic fluid, the liquid that surrounds a fetus during pregnancy. The new information may be used to develop new or improved markers of pregnancy-associated pathological conditions.
Researchers have provided new information about how communication among neurons may be prevented from deteriorating in conditions such as Alzheimer's disease (AD). The new results may lead to new therapies for the treatment of not only AD but also motor neuron diseases and prion diseases.
Scientists have provided the first large-scale study of proteins inside human cells called Jurkat T cells. The study could lead to a better understanding of how proteins inside a specific type of cell work together and may pave the way for future detailed studies of how proteins work in other types of cells.
Scientists report that when people with a transplanted kidney take fluvastatin, a drug against cardiovascular disease, their response to the drug is not influenced by their genetic composition.
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