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The largest trial to examine the impact of colchicine in acute myocardial infarction (MI) found that both acute and long-term colchicine use did not reduce cardiovascular death, myocardial infarction, stroke, or ischemia-driven revascularization.
Results from the large-scale randomized ECLIPSE trial found that a lesion preparation strategy of routine orbital atherectomy had similar outcomes compared with conventional balloon angioplasty prior to implantation of a drug-eluting stent (DES) in severely calcified coronary arteries.
New research led by Cedars-Sinai investigators has reversed liver fibrosis, a gradual buildup of scar tissue in the liver, in laboratory mice. Their achievement marks a crucial step toward potentially creating new treatments for patients with this condition, which can lead to life-threatening diseases including cirrhosis, liver failure and liver cancer.
Retrofitting a portion of the US shipping fleet from internal combustion engines to battery-electric systems could significantly reduce greenhouse gas emissions and be largely cost effective by 2035, according to a new study from Berkeley Lab researchers.
A new, large study led by American Cancer Society (ACS) researchers found that lack of health insurance coverage accounts for a significant proportion of racial and ethnic disparities in advanced-stage diagnosis of multiple cancers.
Researchers at the Icahn School of Medicine at Mount Sinai have discovered a way that ovarian cancer tumors manipulate their environment to resist immunotherapy and identified a drug target that could overcome that resistance. The study, published in the October 30 online issue of Cell used a cutting-edge spatial genomics technology and preclinical animal models, with tumor specimens from ovarian cancer patients further validating the findings. They found that ovarian cancer cells produce a molecule called Interleukin-4 (IL-4), which is typically associated with asthma and the skin condition eczema, also known as atopic dermatitis. The study went on to find that the cancer cells used IL-4 to create a protective environment that kept away killer immune cells, making the tumors resistant to immunotherapy. A drug, dupilumab, which blocks IL-4’s activity, has been approved by the Food and Drug Administration (FDA) and is already used to treat asthma and eczema. This new study suggests dupi
Alternating between sitting and standing at work decreases sedentary behavior, but it has no effect on lowering blood pressure, according to a study led by a West Virginia University epidemiologist. Researchers also found that too much standing during work may have negative effects on cardiovascular health.
A research team has established a Virus-Induced Gene Silencing (VIGS) system in taro, enabling researchers to rapidly verify gene functions in this underutilized crop.
An international team of imaging, engineering and cancer experts is developing a novel mobile breast cancer diagnostic kit to improve early diagnosis in low- and middle-income countries — such as Uganda, where systemic delays lead to an advanced stage diagnosis in 70% of breast cancer cases.
Following a year marked by stronger than expected output and improvement in tackling inflation, the U.S. economy will reach its equilibrium growth rate in 2025 and supply and demand will finally come back into balance after taking major hits during the COVID-19 pandemic, according to an economic forecast from the Indiana University Kelley School of Business.
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