Connecting Research and Experts with Journalists

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Seven top international tobacco control experts are prompting regulators at the U.S. Food and Drug Administration (FDA) to have a broad “open-minded” perspective when it comes to regulating vaporized nicotine products, especially e-cigarettes.

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Obese male mice and normal weight female mice produce female pups that are overweight at birth through childhood, and have delayed development of their breast tissue as well as increased rates of breast cancer. The findings come from one of the first animal studies to examine the impact of paternal obesity on future generations’ cancer risk.

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A modeling study by top tobacco control experts finds that e-cigarettes are likely to provide public health benefits based on “conservative estimates” of the likely uptake of vaping and smoking by adolescents and young adults. If used instead of smoking, e-cigarettes provide the potential to reduce harm and improve public health, says the lead author.

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In a surprise finding, scientists say a single gene can produce many more coding sequences for distinct protein variants than had been known — protein variants that could be used diagnostically or be targets for new drug therapies.

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An animal study suggests that resistance to tamoxifen therapy in some estrogen receptor positive breast cancers may originate from in utero exposure to endocrine disrupting chemicals. The study provides a new path forward in human research as about half of the breast cancers treated with this common cancer therapy do not respond well, say researchers at the Georgetown Lombardi Comprehensive Cancer Center, who led the multi-institutional research.

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In animal models of human breast cancer, inhibiting a single protein restores sensitivity to tamoxifen, a commonly used drug for treatment of some breast cancers.

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Using prominent, graphic pictures on cigarette packs warning against smoking could avert more than 652,000 deaths, up to 92,000 low birth weight infants, up to 145,000 preterm births, and about 1,000 cases of sudden infant deaths in the U.S. over the next 50 years, say researchers from Georgetown Lombardi Comprehensive Cancer Center.

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Georgetown Lombardi Comprehensive Cancer Center researchers have used animal models to reveal new information about the impact – positive and negative – that soy consumption could have on a common breast cancer treatment.

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The first successful randomized trial of its kind provides preliminary evidence that telephone-based smoking cessation counseling given to smokers shortly after undergoing lung cancer screening can be effective at helping people stop smoking.

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A team of investigators led by researchers at Georgetown Lombardi Comprehensive Cancer Center has found that the tumor mutation load, or TML, in a patient’s cancer biopsy varied by age and the type of cancer, along with several other factors.