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Performing neurosurgery on fetuses months before birth, Children's Hospital physicians relieve a potentially devastating condition found in the birth defect spina bifida. MRI scans showed that hindbrain herniation, a cause of hydrocephalus, was dramatically improved.
Researchers at The Children's Hospital of Philadelphia played a major role in today's landmark announcement of the first sequencing of a complete human chromosome -- chromosome 22.
According to a study by doctors at The Children's Hospital of Philadelphia, post-traumatic stress disorder (PTSD) is a common, but overlooked, result of childhood traffic injury in both children and their parents.
A study headed by a physician at The Children's Hospital of Philadelphia shows that a novel combination of drugs achieves strong, sustained results in controlling HIV infection in children.
A small percentage of patients who receive lung transplantation develop a deadly increase in blood ammonia levels, according to a study by University of Pennsylvania Medical Center and The Children's Hospital of Philadelphia researchers (The Annals of Internal Medicine, 2-15-00).
Inserting a beneficial gene into blood immune cells taken from patients infected with HIV blocked the virus from replicating in those cells, reports a Children's Hospital of Philadelphia research group (Gene Therapy, 2-00).
An oral medication, deferiprone, that may be helpful for patients with thalassemia and related blood disorders has fewer adverse effects on white blood cells than previously predicted (British Journal of Haematology, 2-00).
Chromosome 22 yielded a few more secrets to The Children's Hospital of Philadelphia genetics researchers who analyzed details of the chromosome's structure and found evidence that sites with repetitive DNA sequences are prone to rearrangements that delete important genes (Human Molecular Genetics, 3-00).
Encouraging early results for a novel gene therapy designed to improve the clinical course of the bleeding disorder hemophilia B. was reported by The Children's Hospital of Philadelphia and Stanford University Medical Center researchers (Nature Genetics, 3-00).
Computer crash simulation software can predict the likelihood and severity of injuries to children from airbag activation; even children with restraints are at substantial risk from airbags while sitting in the front seat (Archives of Pediatrics and Adolescent Medicine, 3-15-00).
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