Connecting Research and Experts with Journalists

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Scientists have known that it takes combinations of chromatin remodeling factors to keep the processes of self-renewal, proliferation and differentiation of stem cells in proper balance. Now, researchers have discovered that forced expression of chromatin remodeling factor Brg1 induces cell cycle arrest, death and deterioration in mesenchymal stem cells (MSCs), upsetting this delicate harmony.

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Professor Claudio Napoli, a Full Professor at the II University of Naples and Adjunct Professor at the Sbarro Research Institute for Cancer Research and Molecular Medicine in the College of Science and Technology of Temple University, is part of a multicenter team presenting a novel strategy for circumventing safety problems that have plagued gene therapy.

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The role played by the protein cdk9-55 in muscle regeneration and differentiation may lead to new therapies to rebuild muscle tissue damaged by disease, injury, and aging, according to researchers at the Sbarro Institute for Cancer Research and Molecular Medicine at Temple University in Philadelphia and at the University of Siena, Italy.

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The tumor suppressor gene pRb2/p130 may provide the first independent prognostic biomarker in cases of soft tissue sarcoma (STS), according to an international collaboration of researchers.

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A single tumor-suppressor gene may provide a unique marker for senescence in Mesenchymal stem cells (MSCs) in vitro, while also playing a role in moving MSCs into senescence, researchers at the Human Health Foundation and the Sbarro Institute for Cancer Research and Molecular Medicine report.

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Researchers have tagged two new potential targets for treating rhabdomyosarcoma (RMS) -- a highly malignant pediatric tumor thought to arise from mesenchymal stem cells (MSCs) committed to become skeletal muscle cells.

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The clinically approved AIDS drug ABC (Abacavir) can reduce proliferation and induce differentiation of human medulloblastoma cells through the downregulation of telomerase activity, which may make it an effective therapeutic strategy for the treatment of the highly malignant primary brain tumors, according to research published in the International Journal of Cancer.

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A new analysis of the incidence of breast cancer in Italy per 100,000 women between the ages of 0 to 84 from 2000 to 2005 shows a 72 percent spike above official estimates issued by the Ministry of Health, with the sharpest uptick of +28.6 percent found in the youngest group studied (ages 25 to 44).

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Researchers working at the Sbarro Institute for Cancer Research and Molecular Medicine at Temple University in Philadelphia, PA and at the University of Siena in Siena, Italy, have shed light on the possible role of inactivation of the 16INK4A gene in the progression of retinoblastoma.

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Researchers from the Sbarro Institute for Molecular Medicine and Cancer Research at Temple University in Philadelphia and the Human Health Foundation in Spoleto, Italy, have found that MECP2, a gene that modifies the chromatin in the cell, has an important role in stem cell aging.