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Albert LSpada, MD, PhD is Distinguished Professor of Pathology & Laboratory Medicine and Neurology at UC Irvine School of Medicine. He is also the founder and director of the UCI Institute for Neurotherapeutics. He also serves as the Associate Dean for Research Development at the UC Irvine School of Medicine.

Dr. LaSpada's research is focused upon neurodegenerative disease. His lab is seeking the molecular events that underlie neurodegeneration and neuron cell death in spinocerebellar ataxia type 7, spinal & bulbar muscular atrophy, Huntington’s Disease, ALS, Parkinson’s disease, and Alzheimer's disease. 

Dr. LaSpada's team has uncovered evidence for transcription dysregulation, perturbed bioenergetics, and altered protein quality control as contributing factors to neuron dysfunction. By reproducing molecular pathology in mice and in neurons, astrocytes, microglia, and skeletal muscle cells derived from human patient stem cells, they have begun to develop therapies to treat these disorders. 

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UC Irvine School of Medicine podcast with Dr. Albert LaSpada on Ataxia

UC Irvine School of Medicine podcast with Dr. Albert LaSpada on Ataxia
06-Mar-2025 08:00:01 AM EST

UCI researcher leads study linking ALS to immune and central nervous systems

Along with the central nervous system, the immune system may play a fundamental role in Amyotrophic Lateral Sclerosis (ALS), suggesting that bone marrow transplants may be an effective novel treatment for the neurodegenerative disease, according to findings from a research team that included Albert LaSpada, MD, PhD, distinguished professor of pathology, neurology and biological chemistry at the University of California, Irvine School of Medicine.
05-Jul-2022 02:05:50 PM EDT

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