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John Seeley, PhD

Professor, Prevention Science and Special Education

University of Oregon

Behavioral Disorders, Behavioral Health, Emotional Disorders, Mental Health, mental health and college students, Substance Abuse, suicidal ideation, Suicide Prevention

John Seeley serves as the principal investigator of a 4-year collaborative multisite study funded by the National Institute of Mental Health to evaluate adaptive treatment strategies for college students with moderate to severe suicidal ideation delivered through university counseling centers. Since 2016, John has served as an appointed member of the Oregon Alliance to Prevent Suicide and he directs the evaluation activities for the implementation of suicide prevention initiatives funded by the Oregon Health Authority. His research interests include emotional and behavioral disorders, school-based mental health intervention, research design and program evaluation, and digital health technology. Prior to joining the faculty at the University of Oregon, John was a senior research scientist at the Oregon Research Institute. At the University of Oregon, he is a professor in the special education and clinical sciences department and a core faculty member in the Prevention Science program.  In addition to his teaching and mentoring of graduate students and postdoctoral scholars, he serves as the Associate Dean for Research for the College of Education and the Associate Director for the Center on Human Development.

Alzheimer's Disease, Autism Spectrum Disorder, Behavioral Disorders, Epilepsy, Learning, Learning And Memory, Memory, Neurobiology, Neurological Disorders, Psychiatric Disorders, Synapses, Synaptic Transmission, Therapeutic target discovery

Nien-Pei Tsai is an at the and a researcher at the . 

An imbalance in neuronal and synaptic excitability is a common abnormality observed in patients with various psychiatric and neurological disorders, including autism spectrum disorders, epilepsy and Alzheimer's disease. The dysregulation of excitability is thought to exacerbate disease symptoms. Identifying and understanding the mechanisms underlying the dysregulation of excitability could reveal novel therapeutic targets for these diseases. To achieve this goal, we utilize various approaches including molecular and cell biology, biochemistry, electrophysiology, and mouse genetics to understand the regulation of excitability homeostasis at synaptic, neuronal, network and system levels, and how the deficits of those affect behavior in diseases. 

Research Interests:

  • Neurobiology

  • Synaptic transmission

  • Learning and memory

  • Neurological and behavioral disorders

 

Current focuses of Tsai's lab include:

1. Studying activity-dependent translational control in fragile X syndrome

2. Exploring novel transcriptional and post-transcriptional regulators in neurodevelopment 

3. Determining the role of cellular stress response in neuronal plasticity

4. Characterizing the molecular mechanisms contributing to comorbid seizures in Alzheimer's disease

 

Education

  • B.S., National Taiwan University, Taipei, Taiwan, 2002

  • M.Sc., National Yang-Ming University, Taipei, Taiwan, 2004

  • Ph.D., University of Minnesota, Minneapolis, MN, 2009

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