天美传媒

Professor, Department of Pharmacology, University of Colorado School of Medicine, Aurora, CO.

Research has focused on neural mechanisms of adaptation to alcohol, including tolerance and dependence.  Identified a  role of peptide hormones and brain growth factors to modify alcohol tolerance.  

Discovered that one subtype of glutamate receptor, the NMDA receptor, is very sensitive to alcohol, and that increases in NMDA receptor function are involved in alcohol dependence.  This work has led to many further studies by others that focus on the role of the brain  glutamate systems in addiction to alcohol and other drugs.  

Currently focus on systems genetic analysis, using "big data" to understand the genetic contribution to alcohol-related and other complex behaviors.

Michael Leapman, MD was drawn to the field of urology for the opportunity to care for patients with urologic cancers. He aims, above all, to deliver the highest level of care possible with the utmost consideration and compassion for the impact that cancer places on patients, as well as their families, friends and communities.
Dr. Leapman graduated from Cornell University where he majored in Neurobiology and Behavior, and received his medical school degree from the University of Maryland in Baltimore. He completed his General Surgery and Urology training at the Mount Sinai Hospital in New York, NY. Subsequently, he completed a urologic oncology fellowship at the University of California San Francisco (UCSF) accredited by the Society of Urologic Oncology. He joined the faculty at the Yale University School of Medicine and Yale Cancer Center in 2016, specializing in urologic oncology with a joint appointment at the West Haven Veterans Affairs Medical Center.

Dr. Daniel Llano is a professor in the  at the University of Illinois Urbana-Champaign and a full-time faculty member in the Beckman Institute for Advanced Science and Technology’s Neurotechnology for Memory and Cognition Group. He is also a physician-surgeon at Carle Illinois College of Medicine. His field of professional interest is systems neuroscience.
 studies the mechanisms by which complex sounds like speech are processed by the auditory system. He hypothesizes that the auditory system generates internal models of the sensory world and uses these models to extract meaning from complex sensory stimuli. One potential neuronal substrate for this generative model is the massive system of descending projections from the auditory cortex to virtually every level of the subcortical auditory system. These projections are critical for shaping the response properties of neurons in the auditory periphery, but very little is known about their functional organization. 

He employs electrophysiological, novel optical, and advanced anatomical approaches to study the projections from the auditory cortex to subcortical structures. One specific set of issues concerns the role of different cortical subnetworks in complex sound processing. For example, neurons in both cortical layer 5 and cortical layer 6 project to subcortical structures, and the neurons in these layers have very different intrinsic, integrative and synaptic properties. Llano's work explores the different roles that these groups of neurons play in processing complex sound. 

Llano also has a strong interest in studying the reorganization of such networks during neuronal disease. In particular, his lab is developing models of stroke and age-related auditory network dysfunction for the development of novel therapeutic approaches.
His patient care work is focused on aging and neurodegenerative diseases like Alzheimer's.
Research interests:


Computational biology




Imaging


Neurobiology


Optogenetics


Sensory processing


Aging-related diseases


Neurological and behavioral disorders


Education


M.D., University of Illinois Urbana-Champaign 


Ph.D., University of Illinois Urbana-Champaign

A fundamental question in neuroscience is how we perceive and respond to our environment. Our laboratory uses mouse molecular genetics, circuit mapping, and electrophysiological analyses to gain an understanding of the development, organization, and function of neural circuits that underlie the sense of touch. Mouse molecular genetic approaches are used to identify, visualize, and functionally manipulate each of the physiologically defined classes of low-threshold mechanosensory neurons (LTMRs), the primary cutaneous sensory neurons that mediate the sense of touch. We have also gained genetic access to neurons that receive and process LTMR inputs in the spinal cord and propagate this information to the brain. Our current goals are to discover: 1) unique functions and properties of LTMR subtypes; 2) the organization and logic of synaptic connections between LTMR subtypes, spinal cord dorsal horn interneurons and projection neurons, and dorsal column nuclei neurons; 3) ascending pathways that underlie the perception of touch, 4) cellular and circuit level alterations that underlie touch sensitivity deficits in autism spectrum disorders and neuropathic pain, and; 5) mechanisms by which primary somatosensory neurons and touch circuit organization are established during development.
Dr. David D. Ginty (born 1962) is an American  and .
David graduated from  and received his Ph.D. degree in  from  for graduate work with Edward Seidel, on the regulation of  compounds and their metabolism during cell growth and proliferation. Moving to , David completed his postdoctoral research, first, with John Wagner at the  at , and then with Michael Greenberg at , where he made several seminal contributions to  and  signaling in neurons.
In 1995, David was invited by  to move to , , to become a new faculty member of the Department of  at the . In 2000, he became an investigator of the . David remained a faculty member at  for 18 years. In the fall of 2013, David and his laboratory moved from  to , MA, where he became the Edward R. and Anne G. Lefler Professor of Neurobiology in the Department of Neurobiology at , while maintaining his status of an  investigator.
In the 1990s, David received several  awards including a , a  Award, and the Basil O'Connor Starter Scholar Award from the March of Dimes.[] After becoming established, he received a  Neuroscience Investigator's Award from the . In 2015, David was elected into the . In 2017, David was elected to the .
His lab at  discovered functions and mechanisms of action of neuronal growth factors and axon guidance cues, and mechanisms of assembly and functional organization of the neural circuits that underlie autonomic functions and the sense of touch. His lab at  uses a variety of techniques including genetics, circuit mapping, and  analyses to gain understanding of the development, organization, and function of neural circuits that underlie the sense of touch. He uses mouse molecular genetic approaches to identify, visualize, and functionally manipulate physiologically defined classes of low-threshold mechanosensory neurons (LTMRs), the primary cutaneous sensory neurons that mediate the sense of touch, as well as spinal cord neurons that process LTMR information and convey it to the brain.

Nien-Pei Tsai is an  at the  and a researcher at the . 
An imbalance in neuronal and synaptic excitability is a common abnormality observed in patients with various psychiatric and neurological disorders, including autism spectrum disorders, epilepsy and Alzheimer's disease. The dysregulation of excitability is thought to exacerbate disease symptoms. Identifying and understanding the mechanisms underlying the dysregulation of excitability could reveal novel therapeutic targets for these diseases. To achieve this goal, we utilize various approaches including molecular and cell biology, biochemistry, electrophysiology, and mouse genetics to understand the regulation of excitability homeostasis at synaptic, neuronal, network and system levels, and how the deficits of those affect behavior in diseases. 
Research Interests:


Neurobiology


Synaptic transmission


Learning and memory


Neurological and behavioral disorders


 
Current focuses of Tsai's lab include:
1. Studying activity-dependent translational control in fragile X syndrome
2. Exploring novel transcriptional and post-transcriptional regulators in neurodevelopment 
3. Determining the role of cellular stress response in neuronal plasticity
4. Characterizing the molecular mechanisms contributing to comorbid seizures in Alzheimer's disease
 
Education


B.S., National Taiwan University, Taipei, Taiwan, 2002


M.Sc., National Yang-Ming University, Taipei, Taiwan, 2004


Ph.D., University of Minnesota, Minneapolis, MN, 2009

 is a professor in the Department of Psychology and the Neuroscience Program at the University of Illinois Urbana-Champaign and a faculty member in the Beckman Institute for Advanced Science and Technology. Her fields of professional interest are language, memory, hemispheric differences and cognitive neuroscience.
Certain sensory stimuli — words, pictures, faces, sounds — seem to immediately and effortlessly bring to mind a rich array of knowledge that we experience as the "meaning" of those cues. Federmeier's research examines the neurobiological basis of such meaning, asking how world knowledge derived from multiple modalities comes to be organized in the brain and how such information is integrated and made available for use in varied contexts and often in only hundreds of milliseconds. To study these time-sensitive processes, Federmeier uses event-related brain potentials, or ERPs, supplemented by behavioral, eye tracking, and hemodynamic measures.
Research areas:


Language processing


Semantic memory


Aging


Research interests:


Neurobiological basis


Hemispheric differences


Electrophysiology (EEG, ERPs)


Education

Ph.D., cognitive science, University of California at San Diego, 2000