天美传媒

Dr. John Volpi specializes in the evaluation of hospitalized patients and outpatients with cerebrovascular disease, such as ischemic and hemorrhagic stroke as well as the critical care of patients with other neurological diseases. His primary clinical and research interests are in the management and prevention of ischemic stroke and the critical care of patients with neurological illnesses, such as intracerebral hemorrhage, trauma, and nervous system infections.

Dr. Volpi麓s research interests are in the management and prevention of ischemic stroke, and the critical care of patients with neurological illnesses such as intracerebral hemorrhage, epilepsy, and nervous system infections. His studies also involve the use of ultrasound in the evaluation of blood flow to the brain and development of novel therapies for improving patient outcomes in stroke.

Dr. Crino is an internationally recognized physician-scientist specializing in developmental brain disorders. His laboratory has researched mechanisms of altered brain development associated with autism, intellectual disability, and epilepsy, defining developmental disorders associated with intractable epilepsy including autism, hemimegalencephaly, focal cortical dysplasia, and tuberous sclerosis complex (TSC), which he has studied extensively. He has collaborated on identifying several new genes associated with neurodevelopmental disorders, pioneered single cell mRNA and DNA sequencing analysis in resected human tissues; and has used mouse models to plumb the effects of mTOR regulatory genes on cell development in in vitro models using immunocytochemistry, Western assay, mRNA expression analysis, gene transfection, and in vitro cell migration assays.

Before his appointment to Chairman of the UMSOM Department of Neurology, Dr. Crino was professor and vice chair for research at Temple University School of Medicine鈥檚 Shriners Hospital Pediatric Research Center in Philadelphia. Over the last 20 years, his lab has had continuous funding from the National Institutes of Health, through which he has four grants totaling $4.1 million. He has coauthored 151 peer-reviewed manuscripts, chapters, and reviews. He has been invited to lecture all over the world.

Nien-Pei Tsai is an  at the  and a researcher at the . 
An imbalance in neuronal and synaptic excitability is a common abnormality observed in patients with various psychiatric and neurological disorders, including autism spectrum disorders, epilepsy and Alzheimer's disease. The dysregulation of excitability is thought to exacerbate disease symptoms. Identifying and understanding the mechanisms underlying the dysregulation of excitability could reveal novel therapeutic targets for these diseases. To achieve this goal, we utilize various approaches including molecular and cell biology, biochemistry, electrophysiology, and mouse genetics to understand the regulation of excitability homeostasis at synaptic, neuronal, network and system levels, and how the deficits of those affect behavior in diseases. 
Research Interests:


Neurobiology


Synaptic transmission


Learning and memory


Neurological and behavioral disorders


 
Current focuses of Tsai's lab include:
1. Studying activity-dependent translational control in fragile X syndrome
2. Exploring novel transcriptional and post-transcriptional regulators in neurodevelopment 
3. Determining the role of cellular stress response in neuronal plasticity
4. Characterizing the molecular mechanisms contributing to comorbid seizures in Alzheimer's disease
 
Education


B.S., National Taiwan University, Taipei, Taiwan, 2002


M.Sc., National Yang-Ming University, Taipei, Taiwan, 2004


Ph.D., University of Minnesota, Minneapolis, MN, 2009

Chris Dulla is Professor and Interim Chair of the Department of Neuroscience at Tufts University School of Medicine. The principal goal of his research is to understand how neurotransmission contributes to the function of neuronal networks. Neurotransmission is the most basic unit of neuronal communication. Disruption of the basic features of neurotransmission is associated with many neurological diseases. His lab aims to understand how specific properties of synaptic function contribute to network activity, and how changes in neurotransmission are involved in the pathology of disease states such as epilepsy and traumatic brain injury. Dulla is specifically interested in astrocyte glutamate uptake, astrocyte/neuron interactions, GABAergic interneuron development, and metabolic control of neuronal activity. Using advanced neurotransmitter imaging, electrophysiological techniques, and more, his lab aims to answer questions about how neuronal network function is shaped by some of the most basic parameters of neurotransmission. Dulla hope to contribute new understanding and novel therapies to treat epilepsy, traumatic brain injury, and other devastating neurological diseases.