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Expert Directory - Brain Health

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Domenico Pratico, MD, FCPP

Scott Richards North Star Charitable Foundation Chair for Alzheimer’s Research, Founding Director and Professor at Alzheimer's Center at Temple, Professor of Neural Sciences

Alzheimer's Center at Temple University Lewis Katz School of Medicine

Alzheimer's Disease, Brain Health, Dementia, Down Syndrome, Genetics, Neurodegeneration


Domenico Praticò is a Professor of Neural Science at the . He obtained his medical degree from the University of Rome “La Sapienza” School of Medicine, where he also completed a residency program in Internal Medicine. He continued his post-graduate training as a Research Fellow of the Center for Cardiovascular Science at the University College, Dublin, Ireland. Next, he pursued a postdoctoral fellowship in the biology of aging at the University of Pennsylvania, where shortly after he was promoted to Assistant Professor, and later Associate Professor. In 2007 he joined Temple University, School of Medicine, as Associate Professor and Director of the Neurodegenerative Diseases Research Laboratory. Since 2011 he has been Professor of Neural Sciences at the Lewis Katz School of Medicine. In December 2017, he was nominated the Scott Richards North Star Foundation Chair in Alzheimer’s research and appointed as the founding Director of the Alzheimer’s Center at Temple. His main area of investigation is clinical pharmacology with a special focus on the cellular and molecular mechanisms involved in brain health, brain aging, and the pathogenesis of neurodegenerative diseases such as Alzheimer’s Disease and Frontotemporal Dementia. His early research includes pioneering work on the development of specific and sensitive methods to measure oxidative stress in vivo, which was instrumental for the first demonstration that brain oxidative stress is an early event in Alzheimer’s Disease pathogenesis. In addition, his work helped in defining the source and functional role that neuroinflammation plays in neurodegeneration. Pratico’s lab has been on the forefront in the effort to unravel the mechanisms responsible for the effect that dietary lifestyle has on brain health, providing evidence that extra virgin olive oil beneficial effects are secondary to the activation of important intracellular degradation pathways of unwanted materials. His group was the first to demonstrate that intracellular sorting and transport of protein is essential for neuronal health and that it can be a viable therapeutic target when it is dysfunctional. During these years, the main goal of his work has always been translating studies of the basic biology of brain aging and neurodegeneration into new therapeutics by implementing a comprehensive experimental approach which combines in vitro and in vivo models as well as human studies. Internationally known for his work on Alzheimer’s disease, brain health, aging and neurodegeneration, Dr. Pratico has authored over 290 original articles in high impact journals, and more than 25 chapters in thematic books. During his career, he has received many awards for his research accomplishments including the Irvine H. Page Award, Neuroscience Education and Research Award, Zenith Award from the Alzheimer’s Association, and Dorothy Dillon Eweson Lectureship from the American Federation for Aging Research, and the Paul W. Eberman Faculty Research Award, and The Marconi Science Award.

Brain Health, cognitive health, Executive Function, Sedentary Lifestyle

Dr. Pindus’s research focuses on the effects of physically inactive and sedentary lifestyles on cognitive and brain health in children, adolescents and working-age adults. The overarching goal of her research program is to understand how sedentary lifestyles affect cognitive and brain functions and the underlying mechanisms. Her research combines the study of physical activity and sedentary patterns with testing the efficacy of novel intervention strategies to modify sitting patterns and improve executive functions. In her work, she integrates objective methods to assess physical activity and sedentary behaviors with cognitive and psychophysiological methods to understand the effects of physically inactive and sedentary lifestyles on executive functions and their neuroelectric correlates (event-related brain potentials). Her research further incorporates biomarkers to address mechanistic research questions.

Aging, Brain Health, Estrogen, Memory, Menopause, Neuroscience, UW-Milwaukee , Women's Health

Karyn Frick studies the cellular-level questions about memory formation in mammals where the effects of aging, hormones and environmental stimulation are similar to those in humans. She has done seminal work in uncovering the molecular pathways that link the hormone estrogen with memory processes. She can discuss how menopause and Alzheimer’s disease are linked. She has created an estrogen compound to treat the effects of menopause and protect brain function and memory without the side effects that can harm women’s health when they take hormone therapy. She is an elected as a Fellow of the American Psychological Association.

Hannah Keage, PhD

Professor, Cognitive Ageing and Impairment Neurosciences (CAIN) laboratory

University of South Australia

Brain Health

My work focuses on cognitive aging and cognitive impairments, such as dementia and delirium.  I lead the Cognitive Ageing and Impairment Neurosciences (CAIN) laboratory with A/Prof Tobias Loetscher, which is part of the BBB Research Centre.

I am particularly interested in vascular contributions to cognitive aging, the neurophysiology and neuropsychology of delirium, and social cognitive aging.  Our lab works with local councils to develop evidence-based dementia education programs for primary school children and wellbeing workshop materials for older adults.  I am passionate about equity and diversity in science and am involved in a number of community and school science programs.

I am currently a Past president of the Australasian Cognitive Neuroscience Society (https://www.acns.org.au/).

Prior to joining UniSA in 2011, I held post-doctoral positions at the University of Cambridge (2007-11). 

Check out our lab webpage: www.cain.science

 

Qualifications
Doctor of Philosophy Flinders University

Bachelor of Behavioural Science (Honours) Flinders University

Bachelor of Behavioural Neuroscience Monash University

Work history
University of Cambridge UK, 2007-2011

University of South Australia AUS, 2011-present

Alzheimer's and Dementia, Brain Health, burnout at work, Neuropsychology

Dr. Robert Sawyer, PhD, is a board-certified neuropsychologist, serving a dual role at Ochsner Health. As medical director of provider experience in the Ochsner Office of Wellbeing, Dr. Sawyer leads efforts aimed at bolstering the resilience and effectiveness of medical teams amid the pressures of contemporary medicine. He can speak on topics such as workforce wellness and preventing physician burnout.

In addition, Dr. Sawyer serves as medical director of neuroscience value with the Ochsner Neuroscience Institute. He is particularly dedicated to redefining the economic aspects of dementia care, helping health care systems understand the underlying financial needs for establishing and maintaining dementia care programs. He is a co-investigator in a National Institute on Aging/National Institutes of Health study of dementia care management led by the University of California San Francisco. He also chairs the Alzheimer’s Association's recently created workgroup focused on the business case for care navigation. 

Dr. Sawyer earned a doctorate in counseling psychology from the University of Memphis in Tennessee. He completed an internship in neuropsychology with Memphis VA Medical Center in Tennessee, and a fellowship in neuropsychology with VA Maryland Health Care System in Baltimore.

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