Highlights
- Dr. Jain reports results of phase 1 study for non-small cell lung cancer
- Poster presentations highlight latest findings across a range of disease sites
- Annual meeting takes place April 25-30 in Chicago
Newswise — BUFFALO, N.Y. and CHICAGO — Researchers from Roswell Park Comprehensive Cancer Center will report their latest findings to colleagues from around the world at the 2025 annual meeting of the American Association for Cancer Research (AACR) in Chicago, Illinois, April 25-30. The event brings together more than 21,000 professionals from the oncology field — as well as patients, survivors and advocates — to share and learn about recent discoveries.
Invited Talk: A Model for Meeting the Needs of Indigenous Communities
In 2020, launched the nation’s first center for Indigenous cancer research at Roswell Park. Now Chair of the Department of Indigenous Cancer Health at the Buffalo cancer center, he will trace the expanding scope of his department’s influence during his invited talk “” on Wednesday, April 30, from 11:10-11:30 a.m. CDT in Room S106, McCormick Place South, Level 1.
“Our work isn’t just research,” says Dr. Haring, an enrolled member of the Seneca Nation of Indians (Beaver Clan). “It’s also service, education, patient navigation and creating opportunities for the next generation of cancer scientists.” He adds that other cancer centers in North America, Australia and New Zealand have begun creating partnerships with Indigenous nations to address tribal needs and priorities in their respective areas.
“It’s important to talk about what is important to our communities and how we have embedded those priorities into our work, to learn what our colleagues at other sites and centers are doing, to share what we’re doing,” notes Dr. Haring. “All the knowledge that comes back to us goes back to our communities, across the U.S. and beyond.”
Findings of Phase 1 Clinical Trial for Advanced Non-Small Cell Lung Cancer
First author , Assistant Professor of Oncology, Department of Medicine, will present , “Initial results from a phase 1 study of an A2a receptor antagonist, administered as monotherapy and in combination with anti-PD1 therapy in patients with advanced non-small cell lung cancer,” Tuesday, April 29, 9 a.m.-noon CDT, in Section 48, board 3. He will outline findings from a phase 1 clinical trial conducted by Johnson & Johnson.
Late-Breaking Research on Breast Cancer, Multiple Myeloma, Lung Cancer
Three members of the Roswell Park faculty will be featured in sessions on late-breaking research:
First author , Professor of Oncology and Co-Director of the Breast Translational Group, Department of Pharmacology & Therapeutics, will present , “Synergistic effect of tamoxifen and doxorubicin on a novel estrogen receptorβ-p53-p73 axis: A new therapeutic strategy against triple negative breast cancer,” Sunday, April 27, 2-5 p.m. CDT, in Section 50, board 5. , Research Assistant Professor in the Department of Pharmacology & Therapeutics, is first author on the study.
Senior author , Associate Professor of Oncology, Department of Immunology, will discuss , “CD28 drives CAR T cell responses in multiple myeloma,” Sunday, April 27, 2-5 p.m. CDT, in Section 51, board 14.
Senior author , Assistant Professor of Oncology, Department of Pharmacology & Therapeutics, will present , “An agrin mechanotransduction for EGFR-addicted cancers,” Sunday, April 27, 2-5 p.m. CDT, in Section 53, board 5.
First author , Professor of Oncology and Co-Director of the Breast Translational Group, Department of Pharmacology & Therapeutics, will present , “Synergistic effect of tamoxifen and doxorubicin on a novel estrogen receptorβ-p53-p73 axis: A new therapeutic strategy against triple negative breast cancer,” Sunday, April 27, 2-5 p.m. CDT, in Section 50, board 5. , Research Assistant Professor in the Department of Pharmacology & Therapeutics, is first author on the study.
Senior author , Associate Professor of Oncology, Department of Immunology, will discuss , “CD28 drives CAR T cell responses in multiple myeloma,” Sunday, April 27, 2-5 p.m. CDT, in Section 51, board 14.
Senior author , Assistant Professor of Oncology, Department of Pharmacology & Therapeutics, will present , “An agrin mechanotransduction for EGFR-addicted cancers,” Sunday, April 27, 2-5 p.m. CDT, in Section 53, board 5.
Featured Posters Highlight Other Roswell Park Research
Several other Roswell Park experts will present posters documenting findings that advance our understanding in key areas of oncology:
— First author Bhavisha Doshi, MS, Predoctoral Trainee, Department of Pharmacology & Therapeutics, will present “Investigating sex disparities in bladder cancer using carcinogen induced bladder cancer mouse model” Sunday, April 27, 2-5 p.m. CDT, in Section 9, board 15. , Associate Professor of Oncology, Department of Pharmacology & Therapeutics, is senior author of the study.
— First author , Assistant Professor of Oncology, Department of Medicine, will present “Integration of serum and tumor metabolomics reveals distinct metabolic profiles in early onset colorectal cancer” Sunday, April 27, 2-5 p.m. CDT, in Section 12, board 7.
— First author , Associate Professor of Oncology, Department of Cancer Genetics & Genomics, will present “A novel combination immunotherapy for p53 mutant metastatic breast cancer leveraging vulnerabilities in the DNA damage response” Sunday, April 27, 2-5 CDT, in Section 28, board 29. , Associate Professor of Oncology, Department of Medicine, is senior author of the study.
— First author Mohammed Alruwaili, MS, Predoctoral Trainee, Department of Cancer Genetics & Genomics, will present “Novel triple-drug combination strategy for p53 mutant cancers leveraging their DNA damage response liabilities” Tuesday, April 29, 2-5 p.m. CDT, in Section 34, board 18. , Associate Professor of Oncology, Department of Cancer Genetics & Genomics, is senior author of the study.
— First author Dineen Vogler, predoctoral trainee, Department of Cancer Genetics & Genomics, will present “The role of AKT3 in prostate cancer” Sunday, April 27, 2-5 p.m. CDT, in Section 4, board 15. , Distinguished Professor of Oncology, Department of Cancer Genetics & Genomics, is senior author of the study.
— First author Bradley Balk, Predoctoral Trainee, Department of Pharmacology & Therapeutics, will present “Studying the role of chromatin accessibility in lineage plasticity of Rb1-deficient EGFR-mutant lung adenocarcinoma” Monday, April 28, 9 a.m.-noon CDT, in Section 2, board 20. , Distinguished Professor of Oncology, Department of Pharmacology & Therapeutics, is senior author of the study.
— Senior author , Director of PDT Clinical Research, Department of Cell Stress Biology, will present “Imaging tumor oxygenation during interstitial photodynamic therapy” Monday, April 28, 9 a.m.-noon CDT, in Section 6, board 1. The study first author is Emily Oakley-Gawrys, PhD, Postdoctoral Affiliate, Department of Cell Stress Biology.
— Senior author , Director of PDT Clinical Research, Department of Cell Stress Biology, will present “Intraoperative light transmission: A translational dosimteric marker for tumor response in interstitial photodynamic therapy” Monday, April 28, 9 a.m.-noon CDT, in Section 6, board 2. The study first author is Christopher Lawson, Predoctoral Trainee, Department of Cell Stress Biology.
— First author Kohei Chida, Postdoctoral Affiliate, Department of Surgical Oncology, will present “Interstitial photodynamic therapy enhances the efficacy of immune checkpoint inhibitor in estrogen receptor high-expressing breast cancer” Monday, April 28, 9 a.m.-noon CDT, in Section 6, board 13. , Chief of Breast Surgery, is senior author of the study.
— First author Jun Arima, MD, PhD, postdoctoral researcher, Department of Surgical Oncology, will present “ESR1 expression as a predictive biomarker for immune checkpoint inhibitor efficacy in estrogen receptor-positive, HER2-negative breast cancer,” Monday, April 28, 9 a.m.-noon CDT, in section 7, board 5. , Professor of Oncology, Department of Surgery, and Clinical Chief of the Department of Breast Surgery, is senior author of the study.
— First author Sarah Athans, Predoctoral Trainee, Department of Pharmacology & Therapeutics, will present “STAG2-mediated gene expression programs promote invasion in muscle invasive bladder cancer” Monday, April 28, 9 a.m.-noon CDT, in section 10, board 19. , Associate Professor of Oncology, Department of Pharmacology & Therapeutics, is senior author of the study.
— First author Masanori Oshi will present “Intra-tumoral NK cell number is associated with immune response, and combination of it and clinical features is a strong prognostic biomarker in gastric cancer” Monday, April 8, 9 a.m.-noon CDT, in section 30, board 10. , Professor of Oncology, Department of Surgery, and Clinical Chief of the Department of Breast Surgery, is senior author of the study.
— First author Takumi Sato will present “High mesothelin expressing triple negative breast cancer is associated with enhanced cell proliferation but without impact on survival outcomes” Monday, April 28 CDT, 9 a.m.-noon, in section 31, board 8. , Professor of Oncology, Department of Surgery, and Clinical Chief of the Department of Breast Surgery, is senior author of the study.
— First author Peter Fiorica, Predoctoral Trainee, Department of Cancer Prevention & Control, will present “Ancestral and genetic determinants of pathologic tumor infiltrating lymphocytes in a large multi-ethnic population of women with breast cancer” Monday, April 28, 9 a.m.-noon CDT, in section 39, board 24. , Director of Molecular Epidemiology and Vice Chair of Clinical Research, Department of Cancer Prevention & Control, is senior author of the study.
— First author Kavin Velur Ganesan, Predoctoral Trainee, Department of Cancer Genetics & Genomics, will present “Defining the mechanism of semaphorin4D tumorigenesis in prostate cancer models” Tuesday, April 29, 9 a.m.-noon CDT, in section 1, board 2. , Assistant Professor of Oncology, departments of Urology and Cancer Genetics & Genomics, is senior author of the study.
— Payal Goala, MS, Predoctoral Trainee, Department of Medicine, will present “Modulation of Th1/Th17 axis through IFNγ-blockade alleviates Anti-CD19 CAR-T associated toxicities in a pre-clinical immune competent model” Tuesday, April 29, 9 a.m.-noon CDT, in section 37, board 3. , Rustum Family Endowed Chair in Translational Research, is senior author of the study.
— , Associate Professor of Oncology, Department of Cancer Prevention & Control, is senior author of “Self-reported experiences of discrimination and inflammatory-related biomarkers among Black breast cancer survivors,” Tuesday, April 29, 9 a.m.-noon CDT, in section 4, board 8.
— First author Dongbo Xu, PhD, Research Associate, Department of Urology, will present “Modeling luminal urothelial carcinoma in the bladder and the upper tract” Tuesday, April 29, 2-5 p.m. CDT, in section 3, board 2. , Associate Professor of Oncology, Department of Urology, is senior author of the study.
— First author Mohammed Alruwaili, MS, Predoctoral Trainee in Cancer Genetics & Genomics, will present “Novel triple-drug combination strategy for p53 mutant cancers leveraging their DNA damage response liabilities” Tuesday, April 29, 2-5 p.m. CDT, in section 34, board 18. , Associate Professor of Oncology, Department of Cancer Genetics & Genomics, is senior author of the study.
— First author Gabrielle Kennelley will present “Carcinogen withdrawal in the BBN induced mouse model of bladder cancer mimics cigarette smoking cessation in humans with decreased tumor progression” Wednesday, April 30, 9 a.m.-noon CDT, in section 3, board 20. , Associate Professor of Oncology, Department of Cell Stress Biology, is senior author of the study.
— First author Mauricio Flores, Predoctoral Trainee in Pharmacology & Therapeutics, will present “RB1 and TP53 restrict lineage plasticity in prostate cancer by regulating chromatin accessibility” Tuesday, April 29, 9 a.m.-noon CDT, in section 3, board 29. , Professor of Oncology in the Departments of Pharmacology & Therapeutics and Urology, is senior author of the study.
— First author Bhavisha Doshi, MS, Predoctoral Trainee, Department of Pharmacology & Therapeutics, will present “Investigating sex disparities in bladder cancer using carcinogen induced bladder cancer mouse model” Sunday, April 27, 2-5 p.m. CDT, in Section 9, board 15. , Associate Professor of Oncology, Department of Pharmacology & Therapeutics, is senior author of the study.
— First author , Assistant Professor of Oncology, Department of Medicine, will present “Integration of serum and tumor metabolomics reveals distinct metabolic profiles in early onset colorectal cancer” Sunday, April 27, 2-5 p.m. CDT, in Section 12, board 7.
— First author , Associate Professor of Oncology, Department of Cancer Genetics & Genomics, will present “A novel combination immunotherapy for p53 mutant metastatic breast cancer leveraging vulnerabilities in the DNA damage response” Sunday, April 27, 2-5 CDT, in Section 28, board 29. , Associate Professor of Oncology, Department of Medicine, is senior author of the study.
— First author Mohammed Alruwaili, MS, Predoctoral Trainee, Department of Cancer Genetics & Genomics, will present “Novel triple-drug combination strategy for p53 mutant cancers leveraging their DNA damage response liabilities” Tuesday, April 29, 2-5 p.m. CDT, in Section 34, board 18. , Associate Professor of Oncology, Department of Cancer Genetics & Genomics, is senior author of the study.
— First author Dineen Vogler, predoctoral trainee, Department of Cancer Genetics & Genomics, will present “The role of AKT3 in prostate cancer” Sunday, April 27, 2-5 p.m. CDT, in Section 4, board 15. , Distinguished Professor of Oncology, Department of Cancer Genetics & Genomics, is senior author of the study.
— First author Bradley Balk, Predoctoral Trainee, Department of Pharmacology & Therapeutics, will present “Studying the role of chromatin accessibility in lineage plasticity of Rb1-deficient EGFR-mutant lung adenocarcinoma” Monday, April 28, 9 a.m.-noon CDT, in Section 2, board 20. , Distinguished Professor of Oncology, Department of Pharmacology & Therapeutics, is senior author of the study.
— Senior author , Director of PDT Clinical Research, Department of Cell Stress Biology, will present “Imaging tumor oxygenation during interstitial photodynamic therapy” Monday, April 28, 9 a.m.-noon CDT, in Section 6, board 1. The study first author is Emily Oakley-Gawrys, PhD, Postdoctoral Affiliate, Department of Cell Stress Biology.
— Senior author , Director of PDT Clinical Research, Department of Cell Stress Biology, will present “Intraoperative light transmission: A translational dosimteric marker for tumor response in interstitial photodynamic therapy” Monday, April 28, 9 a.m.-noon CDT, in Section 6, board 2. The study first author is Christopher Lawson, Predoctoral Trainee, Department of Cell Stress Biology.
— First author Kohei Chida, Postdoctoral Affiliate, Department of Surgical Oncology, will present “Interstitial photodynamic therapy enhances the efficacy of immune checkpoint inhibitor in estrogen receptor high-expressing breast cancer” Monday, April 28, 9 a.m.-noon CDT, in Section 6, board 13. , Chief of Breast Surgery, is senior author of the study.
— First author Jun Arima, MD, PhD, postdoctoral researcher, Department of Surgical Oncology, will present “ESR1 expression as a predictive biomarker for immune checkpoint inhibitor efficacy in estrogen receptor-positive, HER2-negative breast cancer,” Monday, April 28, 9 a.m.-noon CDT, in section 7, board 5. , Professor of Oncology, Department of Surgery, and Clinical Chief of the Department of Breast Surgery, is senior author of the study.
— First author Sarah Athans, Predoctoral Trainee, Department of Pharmacology & Therapeutics, will present “STAG2-mediated gene expression programs promote invasion in muscle invasive bladder cancer” Monday, April 28, 9 a.m.-noon CDT, in section 10, board 19. , Associate Professor of Oncology, Department of Pharmacology & Therapeutics, is senior author of the study.
— First author Masanori Oshi will present “Intra-tumoral NK cell number is associated with immune response, and combination of it and clinical features is a strong prognostic biomarker in gastric cancer” Monday, April 8, 9 a.m.-noon CDT, in section 30, board 10. , Professor of Oncology, Department of Surgery, and Clinical Chief of the Department of Breast Surgery, is senior author of the study.
— First author Takumi Sato will present “High mesothelin expressing triple negative breast cancer is associated with enhanced cell proliferation but without impact on survival outcomes” Monday, April 28 CDT, 9 a.m.-noon, in section 31, board 8. , Professor of Oncology, Department of Surgery, and Clinical Chief of the Department of Breast Surgery, is senior author of the study.
— First author Peter Fiorica, Predoctoral Trainee, Department of Cancer Prevention & Control, will present “Ancestral and genetic determinants of pathologic tumor infiltrating lymphocytes in a large multi-ethnic population of women with breast cancer” Monday, April 28, 9 a.m.-noon CDT, in section 39, board 24. , Director of Molecular Epidemiology and Vice Chair of Clinical Research, Department of Cancer Prevention & Control, is senior author of the study.
— First author Kavin Velur Ganesan, Predoctoral Trainee, Department of Cancer Genetics & Genomics, will present “Defining the mechanism of semaphorin4D tumorigenesis in prostate cancer models” Tuesday, April 29, 9 a.m.-noon CDT, in section 1, board 2. , Assistant Professor of Oncology, departments of Urology and Cancer Genetics & Genomics, is senior author of the study.
— Payal Goala, MS, Predoctoral Trainee, Department of Medicine, will present “Modulation of Th1/Th17 axis through IFNγ-blockade alleviates Anti-CD19 CAR-T associated toxicities in a pre-clinical immune competent model” Tuesday, April 29, 9 a.m.-noon CDT, in section 37, board 3. , Rustum Family Endowed Chair in Translational Research, is senior author of the study.
— , Associate Professor of Oncology, Department of Cancer Prevention & Control, is senior author of “Self-reported experiences of discrimination and inflammatory-related biomarkers among Black breast cancer survivors,” Tuesday, April 29, 9 a.m.-noon CDT, in section 4, board 8.
— First author Dongbo Xu, PhD, Research Associate, Department of Urology, will present “Modeling luminal urothelial carcinoma in the bladder and the upper tract” Tuesday, April 29, 2-5 p.m. CDT, in section 3, board 2. , Associate Professor of Oncology, Department of Urology, is senior author of the study.
— First author Mohammed Alruwaili, MS, Predoctoral Trainee in Cancer Genetics & Genomics, will present “Novel triple-drug combination strategy for p53 mutant cancers leveraging their DNA damage response liabilities” Tuesday, April 29, 2-5 p.m. CDT, in section 34, board 18. , Associate Professor of Oncology, Department of Cancer Genetics & Genomics, is senior author of the study.
— First author Gabrielle Kennelley will present “Carcinogen withdrawal in the BBN induced mouse model of bladder cancer mimics cigarette smoking cessation in humans with decreased tumor progression” Wednesday, April 30, 9 a.m.-noon CDT, in section 3, board 20. , Associate Professor of Oncology, Department of Cell Stress Biology, is senior author of the study.
— First author Mauricio Flores, Predoctoral Trainee in Pharmacology & Therapeutics, will present “RB1 and TP53 restrict lineage plasticity in prostate cancer by regulating chromatin accessibility” Tuesday, April 29, 9 a.m.-noon CDT, in section 3, board 29. , Professor of Oncology in the Departments of Pharmacology & Therapeutics and Urology, is senior author of the study.
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