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Scientists developed a new way of investing in stocks using natural language processing. Using dynamic topic modeling, a variant of Latent Dirichlet Allocation, the new model uncovers hidden risk factors directly from company reports and translates them into tradable indices with minimal human oversight.
This study uncovers dynamic immune adaptations during pregnancy through single-cell RNA sequencing of peripheral blood mononuclear cells at different pregnancy stages. A gradual reduction in cytotoxicity of T and NK cells, along with decreased MHC-II and CD40 signaling in T and B cells, suggests weakened adaptive immunity. Meanwhile, upregulated pro-inflammatory genes in monocytes may compensate for this reduction. Late pregnancy shows a transition toward immune activation in dendritic and CD4+ T cells. Notably, we highlight a novel pro-aging effect of pregnancy, which may reverse postpartum. These findings enhance our understanding of pregnancy immunity and its impact on disease risk.
A recent study has uncovered a potential breakthrough in treating osteonecrosis of the femoral head (ONFH), a debilitating bone disease that causes severe pain and joint collapse. Researchers have discovered that exosomes derived from M2 macrophages-derived exosomes (M2-Exos) can significantly improve bone regeneration by modulating neutrophil extracellular traps (NETs) and endothelial cell function. These tiny vesicles, packed with miR-93-5p, were shown to reduce harmful NETs formation and enhance blood vessel growth, offering a novel therapeutic approach. This discovery highlights the potential of M2-Exos to address the root causes of ONFH, paving the way for non-invasive treatments that could prevent bone deterioration and improve patient outcomes.
Sandia National Laboratories is helping defend deployed troops and the nation against hypersonic threats. During a March 24 test, the Missile Defense Agency, in cooperation with the Navy, launched a Sandia-developed hypersonic target.
Wistar and collaborators have discovered a type of “molecular glue” that can be used to inhibit certain pathological protein interactions.
Charities lobby on behalf of their corporate board members more than previously recognized.
The James Webb Space Telescope has taken the most detailed image of planetary nebula NGC 1514 to date thanks to its unique mid-infrared observations. Webb’s image brings out the nebula’s nuances, particularly its “fuzzy” dusty rings. Also look for holes in the central pink region where material has broken through. Two central stars, which appear as one in Webb’s image, formed this scene over thousands of years — and will keep at it for thousands more.
Researchers from Jinan University, Huawei, and ByteDance have developed LTAA-FGAC, an innovative authentication system that balances user privacy with public traceability and fine-grained access control to enhance digital security and accountability.
Researchers at Children’s Hospital of Philadelphia (CHOP) developed a longitudinal atlas of neuroblastoma, a common and potentially deadly childhood cancer, to gain deeper understanding into precise molecular mechanisms underlying why and how certain treatments eventually become ineffective.
A new study suggests that stress and depression factor into the relationship between insomnia and hazardous drinking. But because the relationship between poor sleep and heavy drinking goes in both directions, the influence of stress or depression depends on which condition came first, the analysis found.
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