天美传媒

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A preclinical model developed at UT Southwestern Medical Center that recapitulates a rare infant-onset form of diabetes suggests the condition stems from gradual damage to the pancreas through misregulation of a molecular pathway called the unfolded protein response (UPR). The findings, published in Molecular Metabolism, could one day lead to new ways to treat more common subsets of diabetes, including Types 1 and 2, which affect hundreds of millions worldwide.

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A recent publication in the International Journal of Cardiology, Pulmonary artery denervation in pulmonary hypertension: A comprehensive meta-analysis, has shed light on the potential of pulmonary artery denervation (PADN) as an innovative intervention for pulmonary hypertension (PH), a condition that places patients at risk for right heart failure and death.

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In this study, we show that transcriptional regulators, previously linked to development in Caenorhabditis elegans, also control immune responses. Through forward genetic screens, we found that loss of LIN-15B leads to constitutive activation of Intracellular Pathogen Response (IPR) genes. LIN-15B is functionally associated with the DREAM chromatin remodeling complex, and its loss enhances resistance to intracellular pathogens. This immune response depends on the MES-4 histone methyltransferase. We also discovered that other chromatin regulators, including NuRD and SUMOylation factors, similarly repress IPR gene expression, highlighting a new role in immunity for these conserved regulators of development.

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Researchers from the University of Pennsylvania have worked to optimize the use of coffee grounds in pour-over coffee and present their suggestions in Physics of Fluids.

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Minnesota-based startup Maxwell Labs has entered into a cooperative research and development agreement with Sandia National Laboratories and the University of New Mexico to demonstrate laser-based photonic cooling for computer chips.

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New research finds that older adults whose children did not graduate from high school experienced early cognitive decline, while older parents whose children completed college were less likely to experience the onset of dementia.

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The Korea Electrotechnology Research Institute (KERI) and the Korea Institute of Materials Science (KIMS) have jointly developed the 'spray drying technology-based high-performance dry electrode manufacturing technology' for the realization of high-capacity secondary batteries.

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he April issue of The American Journal of Gastroenterology highlights new clinical science and reviews, including the gluten-free diet and exposure to arsenic, internet-delivered cognitive behavior therapy for irritable bowel syndrome, a new guideline on gastric premalignant conditions, and multi-society consensus recommendations on bowel preparation.

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A sea turtle鈥檚 shell is a masterpiece. A new study reveals that marine turtle shells combine flexibility and strength to protect against predators like sharks and stress while optimizing movement. This adaptation highlights the complex design of their shells and provides insights into this remarkable balance of strength and flexibility, which has allowed them to survive in the ocean for millions of years 鈥� an example of evolution shaping species in an environment.

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A team of international scientists has invented a substitute for synthetic chemicals, called PFAS (perfluoroalkyl substances), which are widely used in everyday products despite being hazardous to health and the environment.