Figure 1: Research overview. 1. The extended-focus optical coherence microscopy system. 2. The data acquisition and post-processing pipeline. 3. Exemplary results, showing a volumetric render of the imaged microvascular network and its flow velocity, arterial and venous vessel trees and the blood flow direction within multiple blood vessels.
Cutting-Edge Imaging and Data Processing for Vascular Network Mapping
The newly developed technique uses a Bessel beam to extend the focus of optical coherence microscopy, allowing for a detailed imaging of large sections of the brain. Unlike traditional methods that either look at tiny volumes or lose detail over larger areas, this approach provides a comprehensive view of the vascular network. By integrating high-sensitivity Doppler optical coherence tomography with advanced data processing algorithms, the researchers can precisely measure blood flow velocities and directions across thousands of brain vessels. This technique ultimately makes it possible to capture the interplay between blood flow, vessel size, and connectivity within the brain's intricate microvascular network.
Significance for Neurovascular Research
Understanding the brain’s vascular network is crucial for studying the brain function and neurological diseases such as Alzheimer’s and stroke. This new imaging method enables researchers to observe changes in blood flow and vessel connectivity over time, providing valuable insights into how these conditions develop and progress. Moreover, by visualizing these changes in an intact living brain, the technique allows for the assessment of how potential treatments impact brain blood flow, thus marking a significant advancement in neurological research.
Looking Ahead
The researchers plan to extend the application of this technology to study a range of neurovascular conditions, starting with the effects of stroke and its potential treatments on the blood flow in affected brain regions. Applications to other organs and diseases are also envisioned, which could significantly facilitate vascular research and development of targeted therapies.
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References
DOI
Original Source URL
https://doi.org/10.1038/s41377-024-01649-1
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The Light: Science & Applications will primarily publish new research results in cutting-edge and emerging topics in optics and photonics, as well as covering traditional topics in optical engineering. The journal will publish original articles and reviews that are of high quality, high interest and far-reaching consequence.
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