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On the left, four pathology images from a patient with atypical small cell lung cancer show hallmarks of carcinoid cancer in the lungs (thorax), but signs of classical small cell lung cancer where it has spread to the patient’s brain. Ki67 is a marker of proliferating cells, which are an indication of cancer. On the right, the bottom image shows a zoomed in section of the top image. Here, researchers used an imaging technique called FISH to examine extrachromosomal amplifications (the colorful structures) associated with chromothripsis — chromosomal shattering — in this rare cancer.

Dr. Natasha Rekhtman

Dr. Charles Rudin