Credit: Courtesy of St. Jude Children's Hospital
St. Jude co-corresponding authors Caitlin Zebley, MD, PhD, Department of Bone Marrow Transplantation & Cellular Therapy and Ben Youngblood, PhD, Department of Immunology, used an epigenetic clock to show that T cells can outlive their organism by at least four lifespans and that T cell acute lymphoblastic leukemia hyperproliferation results in cells which appear hundreds of years old.