Smart nanoprobe illuminates prostate cancer cells | Newswise: News for Journalists

Credit: Swati Tanwar and Behnaz Ghaemi; see licensing information below.

How nanoSABER works: The nanoSABER probe enters the cell (upper left) from the circulation. The legumain (found in prostate cancer cells) cleaves the probe into pieces that self-assemble into the spherical nanoprobe, which emits a signal detected by Raman spectroscopy.

« Smart nanoprobe illuminates prostate cancer cells

Credit: Swati Tanwar and Behnaz Ghaemi; see licensing information below.

Optical images of cancerous and normal prostate cells. The red signal is produced by a chemical group known as an alkyne that is exposed on the surface of the enzyme-activated nanoprobe. The signal intensity varies with the amount of legumain found in the cell. DU145 and LNCaP are prostate cancer cell lines while RWPE1 is a normal prostate epithelial cell line.

« Smart nanoprobe illuminates prostate cancer cells

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