Broad-spectrum antiviral candidate targets dengue and SARS-CoV-2

Credit: Kentaro Uemura, created with Biorender.com

The newly identified 2-thiouridine (s2U) shows broad-spectrum antiviral activity against various ssRNA+ viruses including DENV, CHIKV, and SARS-CoV-2. (Kentaro Uemura, created with Biorender.com)

« Broad-spectrum antiviral candidate targets dengue and SARS-CoV-2

Credit: Kentaro Uemura et al., PNAS, October 13, 2023

Dose-response inhibition of viral protein expression (green) in DENV2-infected cells. (Kentaro Uemura et al., PNAS, October 13, 2023)

« Broad-spectrum antiviral candidate targets dengue and SARS-CoV-2

Credit: Kentaro Uemura et al., PNAS, October 13, 2023

Dose-response inhibition of viral replication and in vivo evaluation for DENV (top) and SARS-CoV-2 (bottom). (Kentaro Uemura et al., PNAS, October 13, 2023)

« Broad-spectrum antiviral candidate targets dengue and SARS-CoV-2

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