Eric J. Lenze, MD, holds an antidepressant drug in one hand and aripiprazole, originally approved as an antipsychotic, in the other. Lenze, head of the Department of Psychiatry at Washington University School of Medicine in St. Louis, led a multicenter study that found, in older adults with treatment-resistant depression, that augmenting an antidepressant drug with aripiprazole helped a significant number of patients.