BCG is a live attenuated vaccine used to protect against the development of tuberculosis disease, and is also used as the gold standard treatment for bladder cancer. BCG contains an array of surface lipids that are highly inflammatory (top row). The Texas Biomed team “delipidated” the BCG vaccine by removing some, but not all, of these lipids from the outer layer (right panel). This approach enables the delipidated BCG vaccine to still function and elicit an immune response, but minimizes severe inflammation and tissue damage.