After More than 20 Years, Scientists Have Solved the Full-Length Structure of a Janus Kinase

Credit: Eric Smith/Chris Garcia/Howard Hughes Medical Institute

When a cytokine (green) binds to receptors (teal), two parts of the Janus kinase protein (pink) come together, activating it to send signals inside a cell. In some cancers, mutations in the kinase lock it together, keeping it abnormally active.

« After More than 20 Years, Scientists Have Solved the Full-Length Structure of a Janus Kinase

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