“AdipoR1 is one of the principal enzymes that regulate ceramide content in the eye,” says first and co-corresponding author Dominik Lewandowski, PhD, postdoctoral scholar at the UCI School of Medicine. “Ceramide accumulation is detrimental for the retina and has been associated with non-syndromic retinitis pigmentosa. Our study showed that this imbalance could be effectively targeted pharmacologically by inhibiting two of the three ceramide generation pathways.”