A treatment that rallies the immune system to destroy cancer raised the survival rate for advanced Hodgkin lymphoma patients to a remarkable 92 percent, suggesting a new standard therapy for the disease. The New England Journal of Medicine published the innovative clinical trial results this week.
The Portman lab at the Del Monte Institute for Neuroscience at the University of Rochester discovered that the male roundworms use pheromones and touch signals to determine the sex, age, nutritional health, and mating history of the hermaphrodites and show preference toward worms that have not previously mated with another male and are nutritionally healthy.
The research suggests an easy-to-measure brain process may be a target or biomarker in measuring treatment outcomes in clinical trials for patients with Batten disease.
Researchers at the Del Monte Institute for Neuroscience at the University of Rochester find that microglia—the brain’s immune cells—can trigger cognitive deficits after radiation exposure and may be a key target for preventing these symptoms.
New research appearing today in the journal Nature shows that a cocktail of drugs already approved to treat high blood pressure quickly reduces brain swelling and improves outcomes in animal models of brain injury.
The prevalence of substance abuse, sexually transmitted diseases, homicide and motor vehicle crashes all peak in young adulthood. Yet the study’s findings show that young adults under use ambulatory medical care, infrequently receive preventive care and rarely receive counseling directed at the greatest threats to their health.
Compounds related to Viagra, which is already in clinical trials to prevent heart failure, may also counter the disease in a different way, according to a study published online today in the journal Circulation Research. The results hold promise for the design of a new drug class and for its potential use in combination with Viagra or beta blockers.
A key compound resupplies bone marrow with fast-acting stem cells that can more quickly rekindle blood cell production, according to a study published online today in the journal Blood. While the study was in mice, in the study authors say it has the potential to increase survival among patients with life-threatening blood cell shortages.
Patients who had a cardiac resynchronization device combined with a defibrillator (CRT-D) implanted had a 34 percent reduction in their risk of death or heart failure when compared to patients receiving only an implanted cardiac defibrillator (ICD), according to a landmark study published online today in the New England Journal of Medicine and presented today at the European Society of Cardiology Congress (ESC) in Barcelona, Spain.
A study today in the Proceedings of the National Academy of Sciences shows that a common food additive that gives M&Ms and Gatorade their blue tint may offer promise for preventing the additional "“ and serious "“ secondary damage that immediately follows a traumatic injury to the spinal cord.
An FDA-approved drug used for preventing recurrence of breast cancer shows promise in fighting life-threatening fungal infections common in immune-compromised patients, such as infants born prematurely and patients with cancer.
Researchers at the University of Rochester Medical Center have found a way to block the genetic flaw at the heart of a common form of muscular dystrophy. The results of the study, which were published today in the journal Science, could pave the way for new therapies that essentially reverse the symptoms of the disease.
Scientists have identified a protein that appears not only to be central to the process that causes Parkinson's disease but could also play a role in muting the high from methamphetamine and other addictive drugs.
An early study has found the osteoporosis drug teriparatide (Forteo) enabled aging patients confined to wheelchairs by non-healing fractures to walk and live independently again. The physicians involved are using the word "miraculous" to describe this stem cell-related work and its profound impact on the treatment of bone injuries.
By doing a set of vigorous visual exercises on a computer every day for several months, patients who had gone partially blind as a result of suffering a stroke were able to regain some vision.
The painkiller oxycodone is effective at treating the acute pain of shingles, an illness that often causes severe pain which can become long-lasting and sometimes even permanent. Good treatment is crucial. It's possible that the pain of shingles is more likely to become a long-term problem if the pain is not adequately treated initially.
A type of brain cell that was long overlooked by researchers embodies one of very few ways in which the human brain differs fundamentally from that of a mouse or rat. Human astrocytes are bigger, faster, and much more complex than those in mice and rats.
Choosing to have aggressive brain surgery after suffering a severe stroke generally improves the patients' lives and allows them to live longer.
By studying how mice fight off infection by intestinal worms "“ a condition that affects more than 1 billion people worldwide "“ scientists have discovered that the immune system is more versatile than has long been thought. The work with worms is opening a new avenue of exploration in the search for treatments against autoimmune diseases like diabetes and asthma.
Children with chronic kidney disorder are often subjected to radioactivity and a large number of blood draws when clinicians measure how well their kidneys function. This process is also time-consuming and costly. A new formula has been developed that accurately estimates the level at which children's kidneys are working using height, gender and measuring variables from just a small sample of blood.
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