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By poring over decades worth of data, researchers hope to better determine how pesticides, metals, and exposures to other elements impact Alzheimer’s disease risk

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The Biden Cancer Moonshot Program named Penn Medicine’s Richard E. Phillips, MD, PhD, Chief of the Division of Neuro-Oncology and an assistant professor of Neurology, a Cancer Moonshot Scholar today. Phillips is among 11 scholars included in this year’s cohort, who together will receive a total of $6 million to support cancer research and innovation across the country. The $2.4 million grant will support Phillips as he researches tumor epigenetics, an emerging field pertaining to how changes to DNA can impact the development of cancer cells, with a specific focus on brain tumors in children and young adults.

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In a significant advance against the growing threat of antibiotic-resistant bacteria, , researchers have identified a novel class of antimicrobial agents known as encrypted peptides, which may expand the immune system’s arsenal of tools to fight infection.

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Garret A. FitzGerald, MD, FRS, has been recognized with the 2024 Award for Distinguished Research in the Biomedical Sciences from American Association of Medical Colleges. The award will be presented at the association's annual recognition event on October 30.

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Six experts from the University of Pennsylvania have been elected to the National Academy of Medicine (NAM), one of the nation’s highest honors in the fields of health and medicine. Leaders in the fields of cardiology, nursing, palliative care, health justice, hematology and immunology are among the 100 new members, elected by current NAM members. They join dozens of other Penn members who are part of the prestigious group of health care thought leaders, clinicians, and researchers.

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The Basser Center for BRCA has announced Patrick Sung, DPhil, of The University of Texas Health Science Center at San Antonio, as the recipient of the 2024 Basser Global Prize for his cutting-edge work in the field of DNA damage repair.

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Year-long use of a typical antiviral treatment for shingles was particularly impactful in reducing complications when the condition eventually affected the eye

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A new vaccine provides hope for treating and even preventing the highly contagious and difficult-to-treat Clostridioides difficile infection, more commonly known as C. difficile or C. diff. In animal models, this first mRNA-LNP C. difficile vaccine was found to protect against C. difficile first-time infections and relapsing infections by inducing a robust immune response, promote clearance of existing C. diff bacteria from the gut, and even overcome deficits in host immunity to protect animals after infection.

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The University of Pennsylvania Prevention Research Center (UPenn PRC) has been awarded a grant totaling $6.5 million over five years from the Centers for Disease Control and Prevention (CDC) for community-based prevention and public health research, with a particular focus on cancer.

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A $14M grant will fund research on gene-editing therapies for rare metabolic diseases at the Perelman School of Medicine at the University of Pennsylvania (Penn) and Children’s Hospital of Philadelphia (CHOP). The research will focus specifically on developing therapies for urea cycle disorders, which impact roughly 1 in every 35,000 children.

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A new AI tool is providing a sci-fi level of precision to physicians reviewing images of people’s livers, spleens, kidneys, and more to determine with some exactitude if they are showing any abnormal traits that could shorten a person’s life

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Leading experts in radiation therapy from Penn Medicine’s Abramson Cancer Center and the Perelman School of Medicine will present new results from clinical trials and research studies at the American Society for Radiation Oncology's (ASTRO) 66th Annual Meeting.

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Adults with hemophilia B saw their number of bleeding episodes drop by an average of 71 percent after a single infusion of gene therapy, according to the results of an international Phase III clinical trial published today in the New England Journal of Medicine by researchers from the University of Pennsylvania Perelman School of Medicine and a multicenter group of investigators.

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The vision of people with a rare inherited condition that causes them to lose much of their sight early in childhood was 100 times better after they received gene therapy to address the genetic mutation causing it. Some patients even experienced a 10,000-fold improvement in their vision after receiving the highest dose of the therapy, according to researchers from the Perelman School of Medicine at the University of Pennsylvania who co-led the clinical trial published in The Lancet.

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A new tool for monitoring immune health patterns over time reveals how a pair of checkpoint inhibitor therapies works together to recruit new cancer-fighting T cells with every infusion.

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The small but dedicated Hospital Emergency Response Team works year-round to imagine and prepare for major crises that could disrupt patient care.