Cleveland Clinic virology researchers have found that a specific protein modification to the immune protein MDA5 is key to how our bodies detect and respond to viruses and viral replication.
Columbus, OH; Cleveland, OH, April 7, 2025 – CAS, a division of the American Chemical Society specializing in scientific content and knowledge management, and Cleveland Clinic, an academic health system with a global footprint, announced plans for a strategic collaboration that will unite the organizations’ unique expertise, technology, and data capabilities to fuel clinical research. During the Cleveland Discovery & Innovation Forum, an event highlighting cutting-edge healthcare and life sciences research, the two global organizations announced that their collaboration’s first strategic focus area will be aiming to advance research on health, wellness, and healthy aging. Initial projects the organizations are discussing will focus on drug discovery for brain health, a priority underscored by the relative lack of effective, disease-modifying treatments for Alzheimer’s due to the complex nature of the disease.
Kenneth Merz, PhD, of Cleveland Clinic's Center for Computational Life Sciences, and a research team are testing quantum computing’s abilities in chemistry through integrating machine learning and quantum circuits. Chemistry is one of the areas where quantum computing shows the most potential because of the technology’s ability to predict an unlimited number of possible outcomes. To determine quantum computing's ability to perform complex chemical calculations, Dr. Merz and Hongni Jin, PhD, decided to test its ability to simulate proton affinity, a fundamental chemical process that is critical to life. Dr. Merz and Dr. Jin focused on using machine learning applications on quantum hardware. This is a critical advantage over other quantum research which relies on simulators to mimic a quantum computer’s abilities. In this study, published in the Journal of Chemical Theory and Computation, the team was able to demonstrate the capabilities of quantum machine learning by creating a
CLEVELAND – The Cleveland Cavaliers and Cleveland Clinic have agreed on a 25-year extension of their partnership, lengthening the relationship to more than 55 years altogether. The extension solidifies the relationship as one of the longest continuous partnerships between a professional sports organization and a healthcare provider.
A team of researchers from Cleveland Clinic Genomic Medicine share insights from an early set of 19,000 patients to receive immune checkpoint inhibitor treatments for colorectal cancer in the U.S. The report comes from the laboratory of Stephanie Schmit, PhD, MPH, and was published in JAMA Network Open. It serves as an opportunity to better understand how immune checkpoint inhibitor treatments, including PD-1 and PD-L1 inhibitors, work in a larger population that reflects real-world settings. Dr. Schmit collaborated with a team of researchers that included Moffitt Cancer Center.
Cleveland Clinic researchers developed and validated a prediction model that estimates the risk of developing colorectal cancer and advanced precancerous polyps in adults under 45 years old. The paper was published in Digestive Diseases and Sciences
Researchers from Cleveland Clinic’s Genome Center outlined the pathway human herpes simplex virus-1 (HSV1) can use to contribute to Alzheimer’s disease in aging brains. In a report published in Alzheimer's & Dementia: The Journal of the Alzheimer's Association, investigators also share two FDA-approved, commercially available drugs that reverse this pathway in a laboratory setting. The findings are the first concrete evidence to support the previously controversial link between human herpesviruses (HHVs) and Alzheimer’s disease.
Cleveland Clinic has announced the rollout of Ambience’s AI platform for documentation, clinical documentation integrity (CDI), and point of care coding. This technology aims to provide more time for personal interaction during visits and reduce the administrative workload for caregivers.
Cleveland Clinic Survey: Many Americans Unaware of Heart Health Risks, Skip Medication Doses Approximately 40% of Americans do not recognize the dangers of alcohol consumption, tobacco use, and sleep deprivation
Researchers from the Cleveland Clinic Genome Center have successfully applied advanced artificial intelligence (AI) genetics models to Parkinson’s disease. Researchers identified genetic factors in progression and FDA-approved drugs that can potentially be repurposed for PD treatment. The npj Parkinson’s Disease report uses an approach called “systems biology,” which uses AI to integrate and analyze multiple different forms of information from genetic, proteomic, pharmaceutical and patient datasets to identify patterns that may not be obvious from analyzing one for of data on its own.
A Cleveland Clinic study shows that patients with obesity and fatty liver-related cirrhosis who had bariatric (weight-loss) surgery significantly lowered their future risk of developing serious liver complications compared with patients who received medical therapy alone. The results were published in Nature Medicine journal.
Oxford, OH and Cleveland, OH – January 15, 2025 -  Miami University and Cleveland Clinic are partnering to advance education in quantum computing and elevate Ohio’s global position in this transformative field. Through an innovative partnership, Ohio’s first specialized degree programs and research experiences in quantum computing will be established. This initiative also will cultivate scientific and entrepreneurial talent to develop companies, elevate businesses, and advance organizations that leverage quantum computing.
Columbus Regional Health will join the Cleveland Clinic Connected program, which provides members with access to this world-class healthcare institution’s wealth of knowledge to enhance patient experience and care, safety, and outcomes.
Cleveland Clinic researchers have found definitive proof of a kidney microbiome that influences renal health and kidney stone formation, demonstrating that the urinary tract is not sterile and low levels of bacteria are normal. The Nature Communications publication describes the rigorous multi-pronged approach a team led by Aaron Miller, PhD, and José Agudelo, MD, used to identify and characterize the small bacterial community by combining preclinical, human and dish studies.
Cleveland Clinic Genome Center researchers have unraveled how immune cells called microglia can transform and drive harmful processes like neuroinflammation in Alzheimer’s disease. The study, published in Alzheimer’s & Dementia: The Journal of The Alzheimer’s Association, also integrates drug databases with real-world patient data to identify FDA-approved drugs that may be repurposed to target disease-associated microglia in Alzheimer’s disease without affecting the healthy type.
Cleveland Clinic developed a predictive model to identify patients at risk of developing gastric (stomach) cancer who may benefit from stomach cancer screening. The model is designed to identify who might need regular upper endoscopies to screen for stomach cancer.
Cleveland Clinic researchers are presenting updated findings from their novel study of a vaccine aimed at preventing triple-negative breast cancer, the most aggressive and lethal form of the disease. The study team found that the investigational vaccine was generally well tolerated and produced an immune response in most patients. The team described the side effects of the vaccine, showed the highest tolerated dose to date, and presented the immunologic effects of the vaccine. Findings are being presented at the Society for Immunotherapy of Cancer Annual Meeting.
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