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Scientists have developed a potent anti-cancer compound that inhibits cancer cell growth in a tough-to-treat type of infant leukemia.

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Immune cells use two different routes to produce acetyl-CoA, an essential metabolite required to fight infection and cancer, reports a study led by Van Andel Institute scientists.

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Humans and baker’s yeast have more in common than meets the eye, including an important mechanism that helps ensure DNA is copied correctly, reports a pair of studies published in the journals Science and Proceedings of the National Academy of Sciences.

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Van Andel Institute scientists have identified more than 1,000 previously undetected proteins in common metabolite samples, which persist despite extraction methods designed to weed them out.

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Some proteins shift their shape when exposed to different temperatures, revealing previously unknown binding sites for medications.

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A new study offers a first look into the complex molecular changes that occur in brain cells with Lewy bodies, which are key pathological hallmarks of Parkinson’s disease and some dementias.

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A pair of medications that make malignant cells act as if they have a virus could hold new promise for treating colorectal cancers and other solid tumors, reports a study published today in Science Advances.

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A first-of-its-kind study has identified overactive inflammation and loss of critical protection mechanisms in the brain as potential contributors to suicide risk.

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Nick Burton, Ph.D., has earned a five-year, nearly $2.9 million New Innovator Award from the National Institutes of Health Common Fund to find new ways to fix or prevent insulin resistance, a key driver of Type 2 diabetes.

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Van Andel Institute Chief Scientific Officer Peter A. Jones, Ph.D., D.Sc. (hon), has received a seven-year, nearly $7.9 million grant from the National Cancer Institute’s Outstanding Investigator Award program.

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Van Andel Institute has appointed Eric Swindell, Ph.D., as dean and chief academic officer of Van Andel Institute Graduate School, effective Dec. 4, 2023.

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Van Andel Institute scientists and collaborators have identified a key part of a mechanism that annotates genetic information before it is passed from fathers to their offspring.

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Our cells are powered by tiny “powerplants” called mitochondria, which transform nutrients into fuel that sustains life. But there’s more to the story of mitochondria, says Van Andel Institute Assistant Professor Sara Nowinski, Ph.D.

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Scientists have identified a series of processes that help the brain adapt to damage caused by breakdowns in circuits that govern movement, cognition and sensory perception.

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A metabolic by-product that is more prevalent during fasting may supercharge immune cells as they fight infection and disease, reports an early stage study by Van Andel Institute scientists and collaborators.

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Loss of two key “protector” proteins initiates epigenetic changes that transform healthy lung cells into cancerous ones, according to new research from Van Andel Institute scientists.

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Van Andel Institute scientists have pinpointed how a specific gene mutation triggers an inflammatory cascade that may drive development of treatment-resistant cancers.

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Van Andel Institute’s Hui Shen, Ph.D., and Washington University School of Medicine in St. Louis’s Ting Wang, Ph.D., will co-lead a collaborative project supported by the Somatic Mosaicism across Human Tissues (SMaHT) Network, a new $140 million National Institutes of Health-led effort to better understand the genetic differences between individual cells and tissues in the body.

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Scientists have pinpointed a key driver of low bone density, a discovery that may lead to improved treatments with fewer side effects for women with osteoporosis.

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Researchers have identified two distinct subtypes of insulin-producing beta cells, or ß cells, each with crucial characteristics that may be leveraged to better understand and treat Type 1 and Type 2 diabetes.