A research team at Indiana University Bloomington has uncovered new details about how a tiny virus builds its protective outer shell âa crucial part of its ability to infect cells.
The research team led by Dr. Hyunwoo Kim and Dr. Myungae Bae at the Korea Research Institute of Chemical Technology (KRICT) has developed the nano-probe-based quantitative stiffness measurement technique for a non-alcoholic fatty liver disease (NAFLD) simulate artificial organoid model while minimizing tissue damage.
A Rutgers biochemistry professor explains how omega-6 fatty acids found in Western diets can activate cellular growth pathways in certain breast cancers.
As warehouses go, nuclei are more like libraries than bank vaults. Too many cellular components need access to the genome to lock it down like Fort Knox. Instead, large groupings of more than 1,000 individual protein molecules called nuclear pore complexes (NPCs) pepper the dividing membrane, serving as gateways for materials and messages entering and exiting the nucleus.
AAAS welcomes 471 scientists and engineers in the class of 2024
Nebraska undergrads uncover ancient secrets of human immunity
For human health, prematurely aging cells are a big problem. When a cell ages and stops growing, its function changes, which can cause or worsen cardiovascular disease, Alzheimerâs disease and other chronic diseases. But these cells are also like needles in a haystack, difficult to identify by traditional scientific measures.
A new national programme that aims to position Singapore at the forefront of advancements in RNA science and applications was officially launched today. This new initiative â named National Initiative for RNA Biology and Its Applications (NIRBA) â is supported by the National Research Foundation (NRF) with total funding of S$130 million (US$97 million) over seven years. NIRBA will engage scientists and clinicians from leading institutions like the National University of Singapore (NUS), Nanyang Technological University, Singapore (NTU Singapore), Agency for Science, Technology and Research (A*STAR), and Duke-NUS Medical School.
New research from the University of Chicago shows how a specially trained population of immune cells keeps the peace by preventing other immune cells from attacking their own.
Johns Hopkins Medicine scientists say they have shed new light on how bacteria protect themselves from certain phage invaders â by seizing genetic material from weakened, dormant phages and using it to âvaccinateâ themselves to elicit an immune response.
In a groundbreaking study on the synthesis of cellulose â a major constituent of all plant cell walls â a team of Rutgers University-New Brunswick researchers has captured images of the microscopic process of cell-wall building continuously over 24 hours with living plant cells, providing critical insights that may lead to the development of more robust plants for increased food and lower-cost biofuels production.
Wistar Institute scientists and collaborators describe a next-generation vaccination technology that combines plasmid DNA with a lipid nanoparticle delivery system.
Aging compromises the lymphatic vessels surrounding the brain, disabling waste drainage from the brain and impacting cognitive function. Researchers at WashU Medicine boosted lymphatic vessel integrity in old mice and found improvements in their memory compared with old mice without rejuvenated lymphatic vessels.
An international team of clinical collaborators, led by physician scientists from Dana-Farber Cancer Institute, performed a first-ever clinical test of the targeted therapy avapritinib in pediatric and young patients with a form of high-grade glioma. They found that the drug, already FDA-approved for certain adult cancers, was generally safe and resulted in tumor reduction visible on brain scans, as well as clinical improvement, in 3 out of 7 patients.
Find how a mitochondrial protein protects cancer cells from immunotherapy, giving scientists a new target type to improve solid tumor treatment & save lives.
Rutgers Launches Center to Tackle Barriers to Weight Loss and Other Causes of Disease
A recent study has unveiled the pivotal role of Ferroptosis Suppressor Protein 1 (FSP1) in intervertebral disc degeneration (IDD), a primary cause of chronic lower back pain. Researchers discovered that FSP1, when upregulated by the inflammatory cytokine TNFÎą, accelerates disc degeneration through caspase 3-dependent apoptosis and mitochondrial damage. This finding positions FSP1 as a promising therapeutic target for IDD, potentially offering relief to millions suffering from persistent back pain.
A recent study has unveiled the critical roles of two transcription factors, MAFB and CEBPA, in the development of hypospadias, a common congenital malformation affecting male urethral development. The research reveals that MAFB and CCAAT/enhancer-binding protein alpha (CEBPA) regulate urothelial cell growth via the Wnt/β-catenin signaling pathway, offering new insights into the genetic mechanisms underlying this condition. These findings pave the way for innovative therapeutic strategies and a deeper understanding of the genetic and molecular foundations of hypospadias.
Early diagnosis is crucial in disease prevention and treatment. Many diseases can be identified not just through physical signs and symptoms but also through changes at the cellular and molecular levels. When it comes to a majority of chronic conditions early detection, particularly at the cellular level, gives patients a better chance for successful treatment.
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