Researchers at WashU Medicine have identified a possible way to make glioblastoma cells vulnerable to different types of immunotherapy. The strategy, which they demonstrated in cells in the lab, forces brain cancer cells to display targets for the immune system to attack. Their study was published in Nature Genetics.
Researchers at the University of Michigan Rogel Cancer Center have discovered a key reason why some cancers do not respond to immunotherapy: A metabolite transporter within the tumor microenvironment that blocks a key type of tumor cell death integral to immune response.
Ivan Vujkovic-Cvijin, PhD, is a pioneer in the study of the gut microbiota and the surprising ways these microorganisms living in our digestive tracts affect our overall health. His discoveries have been featured in Nature, Science Translational Medicine, Cell Reports and other top scientific journals.
Newly-published guidance from the American College of Allergy, Asthma & Immunology (ACAAI), the American Academy of Allergy, Asthma & Immunology (AAAAI) and the American Academy of Otolaryngic Allergy (AAOA) provides useful recommendations to insurance companies regarding appropriate documentation requirements for allergen immunotherapy.
New MSK research marks a potential advance against RAS-driven cancers; breaks down data silos to better predict cancer outcomes with the help of artificial intelligence (AI); identifies two enzymes vital for maintaining brain health; uncovers how changes to “helper” proteins drive cancer cell survival; develops a new model for investigating lung cancer metastasis; and uses AI to improve outcome predictions in sarcoma.
A new study led by Rutgers Health researchers has uncovered important insights into vaccination patterns among LGBTQ+ adults in New Jersey and New York. The findings, published in the journal Vaccine, shed light on disparities in vaccine uptake within this diverse population.
In APL Bioengineering, researchers employed analysis tools and machine learning algorithms to identify two genes linked to rheumatoid arthritis and osteoporosis that could serve as diagnostic tools and potential targets for treatments. Drawing from a large database of genetic information, they gathered dozens of sequenced genomes from people with rheumatoid arthritis and osteoporosis to look for any similarities, using recently developed computational methods to narrow down their search. They identified genes ATXN2L and MMP14 as significantly associated with the progression of both rheumatoid arthritis and osteoporosis.
A new study has found a surprising link between high levels of methylmalonic acid and the weakening of CD8+ T cells, shedding light on potential pathways through which aging may promote lung cancer progression. Moffitt Cancer Center researchers have found new insights into how metabolic changes associated with aging can impact immune responses against tumors.
Scientists investigating animal viruses with potential to infect humans have identified a critical protein that could enable spillover of a family of organisms called arteriviruses.
Researchers at WashU Medicine have found a process by which the brain guards against attack by the immune system. In mice with multiple sclerosis, such "guardian" proteins that train the immune system were drastically depleted, and replenishing them improved symptoms, according to a study in Nature.
The University of Texas MD Anderson Cancer Center’s Research Highlights showcases the latest breakthroughs in cancer care, research and prevention. These advances are made possible through seamless collaboration between MD Anderson’s world-leading clinicians and scientists, bringing discoveries from the lab to the clinic and back.
A new analysis led by researchers at Washington University School of Medicine in St. Louis has revealed detailed 3D maps of the internal structures of multiple tumor types. These cancer atlases reveal how different tumor cells — and the cells of a tumor’s surrounding environment — are organized, in 3D, and how that organization changes when a tumor spreads to other organs. The detailed findings offer scientists valuable blueprints of tumors that could lead to new approaches to therapy and spark a new era in the field of cancer biology, according to the researchers.
Using computational tools, researchers from the Johns Hopkins Kimmel Cancer Center and the Johns Hopkins University School of Medicine have developed a method to assess which patients with metastatic triple-negative breast cancer could benefit from immunotherapy.
In a significant advance against the growing threat of antibiotic-resistant bacteria, , researchers have identified a novel class of antimicrobial agents known as encrypted peptides, which may expand the immune system’s arsenal of tools to fight infection.
El alergista James Tracy, DO (Doctor en Medicina Osteopática), de Omaha, NE, fue instalado como presidente del Colegio Americano de Alergia, Asma e Inmunología (ACAAI) en la Reunión Científica Anual del ACAAI el 27 de octubre en Boston. La alergista Cherie Zachary, MD, de Eagan, Minnesota, fue elegida presidenta electa del ACAAI.
Allergist James Tracy, DO, of Omaha, NE, was installed as president of the American College of Allergy, Asthma and Immunology (ACAAI) at the ACAAI Annual Scientific Meeting on October 27 in Boston. Allergist Cherie Zachary, MD, of Eagan, MN, was elected ACAAI president-elect.
IgA nephropathy is an autoimmune kidney disease, and complement, a component of the innate immune system, plays a role in the condition’s pathogenesis. Investigators have developed and tested a novel gene therapy that enters kidney cells and enables them to block complement activation. The research will be presented at ASN Kidney Week 2024 October 23– 27.
A newly described stage of a lymph node-like structure seen in liver tumors after presurgical immunotherapy may be vital to successfully treating patients with hepatocellular carcinoma, according to a study by researchers from the Johns Hopkins Kimmel Cancer Center.
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