A modified herpes virus that targets spinal cord nerve cells to treat neurogenic bladder in people with spinal cord injury is underway in a first-in-human clinical trial by UTHealth Houston at TIRR Memorial Hermann.
Spatial transcriptomics is a cutting-edge technique that characterizes gene expression within sections of tissue, such as heart, skin or liver tissue. Scientists at St. Jude and the University of Wisconsin-Madison today share a generative algorithm for achieving both high genome and image resolution.
FASEB welcomes the inaugural Fellows for the Future cohort, supporting early-career researchers from historically excluded groups who are dedicated to promoting inclusion in scientific societies.
Like a football team disrupting the opponent’s play, Michelle Ozbun, PhD, and Jason McConville, PhD, at the UNM Comprehensive Cancer Center are designing a gel to prevent cancers caused by human papillomaviruses (HPVs). No other antiviral treatments for HPV diseases are available.
A code developed at the University of Michigan is now helping patients in FDA-cleared software.
The University of Texas MD Anderson Cancer Center’s Research Highlights showcases the latest breakthroughs in cancer care, research and prevention. These advances are made possible through seamless collaboration between MD Anderson’s world-leading clinicians and scientists, bringing discoveries from the lab to the clinic and back.
The immune system typically can ramp up the body’s defenses to clear out an invading threat without issue. Glitches can happen, however, with sepsis occurring when the mustered army of cells also attacks the body’s own tissues and organs as if they were enemy combatants.
A new “self-driving” microscope developed by UT Southwestern Medical Center researchers solves two fundamental challenges that have long plagued microscopy: first, imaging living cells or organisms at dramatically different scales, and second, following a specific structure or area of interest over long periods of time.
He didn’t know it then, but when Ryan was little, his sister would dedicate her birthday wish each year to one request: that Ryan’s hemophilia would be cured. Maybe all that wishing paid off. At age 22, his doctor at Children's Hospital Los Angeles told him he could be eligible for a breakthrough gene therapy treatment for hemophilia B.
University of Maryland School of Medicine (UMSOM) researchers helped conduct an important new global health study that found a vaccine that protects against five strains of meningitis prevalent in sub-Saharan Africa is safe and effective for use in young children beginning at 9 months of age.
In a preclinical study, researchers at Children’s Hospital of Philadelphia (CHOP) demonstrated a novel gene therapy with potentially increased effectiveness and safety for the treatment for metachromatic leukodystrophy (MLD), a rare disease in young children characterized by the deficient activity of a critical enzyme.
A grant from the U.S. Department of Veterans Affairs (VA) will aid Wayne State University researchers in finding new insights into diabetes and its onset.
As global temperatures rise, the ability to understand how plants respond to heat has never been more critical. A recent study has uncovered a molecular mechanism by which elevated temperatures inhibit flowering in Osmanthus fragrans, a beloved ornamental plant. The research highlights how the OfC3H49 gene, activated by heat, suppresses flowering by inhibiting vital flowering-related genes. This discovery not only enriches our understanding of how temperature controls flowering but also paves the way for developing climate-resilient plant varieties and improving ornamental plant cultivation strategies.
Insects, diseases, and abiotic stressors cause losses of millions of tons of wheat and cost farmers $100s of millions each year.
Long-term and precise intracellular signal detection is critical for advancing our understanding of brain diseases and developing effective diagnostic tools. A breakthrough method has been introduced to enhance the stability and fidelity of recording signals at the single-cell level using ultrafine electrodes (UME). By controlling the tip exposure of UMEs, researchers have demonstrated a significant improvement in their ability to resist environmental interference, thus improving signal-to-noise ratio and sensitivity, and the collection area has been precisely controlled. This method promises to enhance the performance of implantable neural interfaces for real-time monitoring of intracellular signals.
A new fully automated in vivo screening system (AISS) has been developed to transform drug evaluation by enabling rapid, precise, and non-invasive multi-organ imaging in zebrafish. Integrating cutting-edge microfluidic technology with computer-vision-based control, this innovative system automates every aspect of zebrafish larvae handling— from loading and encapsulation to immobilization and drug exposure.
A recent study reveals how the expansion and functional divergence of terpene synthase genes (TPSs) in flowering plants (angiosperms) have driven the astonishing diversity of terpenes—critical compounds involved in plant defense, floral scents, and fruit flavors.
La estenosis de la válvula aórtica (AoS) es un problema de salud importante que afecta a más de 1,5 millones de americanos y millones de personas en todo el mundo. Investigadores de Mayo Clinic están analizando el uso de un nuevo fármaco llamado ataciguat para controlar la AoS.
يُعد تضيّق الصمام الأورطي مشكلة صحية كبيرة تؤثر في أكثر من 1.5 مليون أمريكي وملايين آخرين حول العالم. ويستكشف الباحثون في مايو كلينك استخدام دواء جديد يُسمى "أتاسيغوات" لإدارة تضيّق الصمام الأورطي.
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