A New Approach to Asthma Treatment: Harnessing the Liver to Reprogram the Immune System
NYU Tandon School of EngineeringResearchers developed liver-targeted immunotherapy (LIT), a novel approach that chemically modifies allergens with mannose sugars, directing them to the liver where immune tolerance develops. In preclinical trials, just two LIT doses provided year-long asthma protection without triggering allergic reactions, outperforming traditional immunotherapy.