Feature Channels: All Journal News

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In a groundbreaking study, researchers at McMaster University have identified a potential treatment for Sandhoff and Tay-Sachs diseases—two rare, often fatal lysosomal storage disorders that cause progressive damage to nerve cells in the brain and spinal cord. After years of investigating the diseases’ underlying mechanisms, the research team has identified an existing FDA-approved drug that could significantly improve quality of life for affected patients and their families.

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A small clinical trial shows promising results for patients with triple-negative breast cancer who received an investigational vaccine designed to prevent recurrence of tumors. Conducted at Washington University School of Medicine in St. Louis with a therapy designed by WashU Medicine researchers, the trial is the first to report results for this type of vaccine — known as a neoantigen DNA vaccine — for breast cancer patients.

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Results from a study in Malawi showed that chewing gum containing xylitol, a naturally occurring alcohol sugar, was associated with a 24% reduction in preterm birth. The findings were published today in Med (a Cell Press journal). Researchers found that the group of pregnant individuals randomized to receive chewing gum also saw a 30% drop in low-birthweight babies, when compared with the control group which did not receive xylitol gum, noted lead author Dr. Greg Valentine, associate professor of pediatrics at the University of Washington School of Medicine.

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Vulnerable populations without access to green space and exposed to higher temps were most affected

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University of Maryland School of Medicine Researchers Identify Neurobiological Changes Leading to Increase Release of the Brain Chemical Dopamine and Its Target Neurons Linked to Addiction-Like Behavior With the increased legalization of recreational cannabis, as many as 1 in 5 pregnant women in the U.S. are now using the drug to help with morning sickness, lower back pain or anxiety.

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Recent advances in bladder cancer treatments may offer hope of curative care to more patients, including those with high-risk localized, muscle-invasive disease, according to a New England Journal of Medicine editorial published by Matthew Milowsky, MD, FASCO, a bladder cancer expert at UNC School of Medicine and UNC Lineberger Comprehensive Cancer Center.

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Un estudio de Mayo Clinic sugiere que un estent en forma de reloj de arena podría mejorar el flujo sanguíneo y aliviar el dolor torácico intenso y recurrente en personas con microangiopatía.

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Um estudo da Mayo Clinic sugere que um stent em forma de ampulheta poderia melhorar o fluxo sanguíneo e aliviar a dor torácica intensa e recorrente em pessoas com microangiopatia.

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A la mayoría de la gente no le gusta aplicarse vacunas o inyecciones para recibir tratamientos. Por eso, los investigadores trabajan para crear más medicamentos, como los que se fabrican a partir de ARN mensajero (ARNm), que puedan pulverizarse e inhalarse. Un estudio publicado en la revista Journal of the American Chemical Society informa sobre los avances para hacer posible los medicamentos de ARNm inhalables. Los investigadores indican que la nanopartícula de polímero lipídico, que es estable cuando se nebuliza y libera aerosoles (gotitas líquidas) en los pulmones de ratones de forma satisfactoria, se optimizó para contener el ARNm.

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Los rayos X son un componente habitual de las pruebas diagnósticas y el monitoreo industrial, y se utilizan para todo, desde el control de los dientes hasta el escaneo de maletas en el aeropuerto. Sin embargo, los rayos de elevada energía también producen radiación ionizante, que puede ser peligrosa tras exposiciones prolongadas o excesivas. Ahora, investigadores que publican en ACS Central Science han avanzado hacia rayos X más seguros con la creación de un detector altamente sensible y plegable que genera imágenes de buena calidad con dosis más pequeñas de estos rayos.

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After a comprehensive two-year follow-up, researchers at the UCLA Health Jonsson Comprehensive Cancer Center found that MRI-guided stereotactic body radiotherapy (SBRT) for prostate cancer significantly reduced long-term side effects and improved quality of life, particularly in bowel and sexual health, compared to conventional CT-guided treatment.

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A recent study published in the journal Scientific Reports correlates higher levels of pollutant particulate matter to higher occurrences of head and neck aerodigestive cancer.

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Researchers have developed an AI powered model that — in 10 seconds — can determine during surgery if any part of a cancerous brain tumor that could be removed remains, a study published in Nature suggests. The technology, called FastGlioma, outperformed conventional methods for identifying what remains of a tumor by a wide margin. Researchers say it has the potential to change the field of neurosurgery by immediately improving comprehensive management of patients with diffuse gliomas.

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A new study highlights how some marine life could face extinction over the next century, if human-induced global warming worsens.

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The Association for Molecular Pathology published a joint consensus report with the Association of Public Health Laboratories that reviews and summarizes standard concepts and best practices for next-generation sequencing methods for SARS-CoV-2 genomic surveillance.