Latest news from Joslin Diabetes Center on Newswise en-us Copyright 2024 Newswise 115 31 / /images/newswise-logo-rss.gif /articles/weight-loss-surgery-provides-superior-long-term-benefits-for-patients-with-type-2-diabetes-study-finds/?sc=rsin /articles/weight-loss-surgery-provides-superior-long-term-benefits-for-patients-with-type-2-diabetes-study-finds/?sc=rsin Tue, 05 Mar 2024 15:05:38 EST A landmark study conducted at four sites, including Joslin Diabetes Center, reports that people with type 2 diabetes who underwent bariatric surgery achieved better long-term blood glucose control compared to people who received medical management plus lifestyle interventions. Participants who underwent bariatric surgery, also called metabolic or weight-loss surgery, were also more likely to stop needing diabetes medications and had higher rates of diabetes remission up to 12 years post-surgery. The findings, published in JAMA, suggest that weight loss surgery may carry benefits for people with diabetes, even those who are below the traditional BMI threshold of 35 for bariatric surgery. Joslin Diabetes Center /articles/shifting-focus-investigators-describe-changes-to-pancreatic-cell-at-onset-of-type-1-diabetes/?sc=rsin /articles/shifting-focus-investigators-describe-changes-to-pancreatic-cell-at-onset-of-type-1-diabetes/?sc=rsin Mon, 26 Feb 2024 05:00:00 EST About eight million people live with Type 1 diabetes (T1D) worldwide, a chronic autoimmune condition in which the body attacks and destroys its own insulin-producing β-cells (pronounced "beta") in the pancreas, leading to a lack of insulin and inability to regulate blood sugar. It's not known why the body suddenly perceives its own β-cells as the enemy; some lines of evidence suggest environmental factors such as viral infections may trigger the onset of T1D, others suggest genetics may also play some role. Groundbreaking research by investigators at Joslin Diabetes Center sheds new light on the specific changes β-cells go through at the onset of T1D. Their findings--published in Nature Cell Biology--offer new avenues for targeted interventions for the chronic autoimmune condition. Joslin Diabetes Center /articles/phase-3-trial-finds-oral-empagliflozin-provided-safe-glycemic-control-in-children-with-type-2-diabetes/?sc=rsin /articles/phase-3-trial-finds-oral-empagliflozin-provided-safe-glycemic-control-in-children-with-type-2-diabetes/?sc=rsin Thu, 23 Feb 2023 14:55:59 EST Researchers recently completed a phase 3 clinical trial that assessed the efficacy and safety of two different classes of oral agents for the treatment of type 2 diabetes in young people aged 10-17 years. Joslin Diabetes Center /articles/researchers-shed-light-on-how-exercise-preserves-physical-fitness-during-aging/?sc=rsin /articles/researchers-shed-light-on-how-exercise-preserves-physical-fitness-during-aging/?sc=rsin Thu, 05 Jan 2023 13:55:12 EST Researchers investigated the role of one cellular mechanism in improving physical fitness by exercise training and identified one anti-aging intervention that delayed the declines that occur with aging in the model organism. Joslin Diabetes Center /articles/exercise-and-obesity-have-opposite-impact-on-muscle-fat-tissues-researchers-demonstrate/?sc=rsin /articles/exercise-and-obesity-have-opposite-impact-on-muscle-fat-tissues-researchers-demonstrate/?sc=rsin Wed, 05 Oct 2022 14:15:03 EST First-of-its-kind dissection of adipose and muscle tissues reveal single-cell changes in metabolic tissues Joslin Diabetes Center /articles/study-reverses-long-held-ideas-about-relationship-among-diabetes-fat-and-cardiovascular-disease/?sc=rsin /articles/study-reverses-long-held-ideas-about-relationship-among-diabetes-fat-and-cardiovascular-disease/?sc=rsin Fri, 05 Aug 2022 10:35:19 EST In a paper published in Circulation Research, scientists describe a series of studies designed to determine the relationship among insulin, fats and the vascular system. Joslin Diabetes Center /articles/gut-microbe-peptide-implicated-in-triggering-type-1-diabetes/?sc=rsin /articles/gut-microbe-peptide-implicated-in-triggering-type-1-diabetes/?sc=rsin Mon, 25 Jul 2022 17:40:04 EST Researchers have identified a species of human gut bacterium that makes a protein containing a sequence of amino acids that mimics the insulin peptide targeted by the immune system in type 1 diabetes. Joslin Diabetes Center /articles/crosstalk-between-pancreatic-cells-may-drive-rare-form-of-diabetes/?sc=rsin /articles/crosstalk-between-pancreatic-cells-may-drive-rare-form-of-diabetes/?sc=rsin Thu, 20 Jan 2022 14:05:31 EST Joslin researchers show how one form of the rare inherited disease known as mature onset diabetes of the young (MODY) is driven by mutated digestive enzymes generated in pancreatic exocrine cells that are then taken up by neighboring insulin-secreting beta cells. Joslin Diabetes Center /articles/cracking-the-code-for-a-new-system-of-cell-to-cell-signaling/?sc=rsin /articles/cracking-the-code-for-a-new-system-of-cell-to-cell-signaling/?sc=rsin Wed, 22 Dec 2021 16:10:04 EST Joslin discovery about exosomes (cell fragments that regulate other cells) may help to advance RNA gene therapies for many diseases. Joslin Diabetes Center /articles/insulin-resistance-pinned-to-cell-signaling-defects-that-could-act-as-therapy-targets/?sc=rsin /articles/insulin-resistance-pinned-to-cell-signaling-defects-that-could-act-as-therapy-targets/?sc=rsin Mon, 20 Sep 2021 07:05:28 EST Insulin resistance in the general population seems likely to be caused by a series of cell-specific signaling defects some of which appear to be sex-specific. In addition, only a portion of the defects are shared with those seen in diabetes, pointing towards the existence of novel pathways behind insulin resistance in the general population. According to researchers, this could also be the starting point for new therapeutics to tackle insulin resistance, which is the major driver of type 2 diabetes and metabolic syndrome and is present in 20-30% of the general population in the United States. Joslin Diabetes Center /articles/newly-discovered-proteins-provide-protection-against-progression-of-kidney-disease-in-diabetes/?sc=rsin /articles/newly-discovered-proteins-provide-protection-against-progression-of-kidney-disease-in-diabetes/?sc=rsin Wed, 30 Jun 2021 14:55:00 EST Elevated levels of three specific circulating proteins are associated with protection against kidney failure in diabetes, according to research from the Joslin Diabetes Center in Boston. Joslin Diabetes Center /articles/ancient-gut-microbiomes-may-offer-clues-to-modern-diseases/?sc=rsin /articles/ancient-gut-microbiomes-may-offer-clues-to-modern-diseases/?sc=rsin Wed, 12 May 2021 11:20:05 EST Scientists are rapidly gathering evidence that variants of gut microbiomes, the collections of bacteria and other microbes in our digestive systems, may play harmful roles in diabetes and other diseases. Joslin Diabetes Center /articles/pain-receptors-linked-to-the-generation-of-energy-burning-fat-cells-implications-for-obesity-therapy/?sc=rsin /articles/pain-receptors-linked-to-the-generation-of-energy-burning-fat-cells-implications-for-obesity-therapy/?sc=rsin Mon, 12 Apr 2021 13:05:56 EST A new source of energy expending brown fat cells has been uncovered by researchers at the Joslin Diabetes Center, which they say points towards potential new therapeutic options for obesity. According to the new report, published in Nature Metabolism >on 12 March 2021, the key lies in the expression of a receptor called Trpv1 (temperature-sensitive ion channel transient receptor potential cation subfamily V member 1) -- a protein known to sense noxious stimuli, including pain and temperature. Joslin Diabetes Center /articles/kids-metabolic-health-can-be-improved-with-exercise-during-pregnancy-here-s-why/?sc=rsin /articles/kids-metabolic-health-can-be-improved-with-exercise-during-pregnancy-here-s-why/?sc=rsin Tue, 30 Mar 2021 11:30:55 EST BOSTON - (March 25, 2021) - A mechanism has been identified that explains how physical exercise in pregnancy confers metabolic health benefits in offspring. According to researchers, the key lies with a protein called SOD3, vitamin D and adequate exercise, with the outcomes possibly forming the first steps to designing rational diet and exercise programs to use during pregnancy and particularly when mothers may also be overweight or obese. Joslin Diabetes Center /articles/routine-eye-scans-may-give-clues-to-cognitive-decline-in-diabetes/?sc=rsin /articles/routine-eye-scans-may-give-clues-to-cognitive-decline-in-diabetes/?sc=rsin Mon, 04 Jan 2021 13:20:19 EST In older people with type 1 diabetes, damage to the retina may be linked to memory problems and other cognitive conditions.BOSTON - (December 31, 2020) - As they age, people with diabetes are more likely to develop Alzheimer's disease and other cognitive disorders than are people without diabetes. Scientists at Joslin Diabetes Center now have shown that routine eye imaging can identify changes in the retina that may be associated with cognitive disorders in older people with type 1 diabetes. Joslin Diabetes Center /articles/can-risk-in-diabetes-reduced-with-intensive-control-of-blood-glucose-and-blood-pressure/?sc=rsin /articles/can-risk-in-diabetes-reduced-with-intensive-control-of-blood-glucose-and-blood-pressure/?sc=rsin Wed, 16 Dec 2020 14:55:42 EST BOSTON - (December 16, 2020) - Intensive interventions to reduce blood glucose and blood pressure levels in type 2 diabetes reduce the risk of developing cardiovascular autonomic neuropathy (CAN), a frequent but underdiagnosed complication of diabetes that can be life-threatening. In a study led by Alessandro Doria , MD, PhD, MPH, from the Joslin Diabetes Center and Harvard Medical School, and Rodica Pop Busui, MD, PhD, of the University of Michigan, published online in Diabetes Care , researchers found that intensive glycemic control reduced CAN risk by 17%, while intensive blood pressure control reduced risks by 22%. Joslin Diabetes Center /articles/lipid-component-identified-in-breast-milk-may-play-an-important-role-in-early-childhood-weight-development/?sc=rsin /articles/lipid-component-identified-in-breast-milk-may-play-an-important-role-in-early-childhood-weight-development/?sc=rsin Tue, 08 Dec 2020 13:10:46 EST A lipid metabolite called 12,13-diHOME has been identified in human breast milk and appears to be associated with beneficial infant weight gain and body Study suggests that when new mothers exercise, they likely improve newborn's longer term metabolic health. Joslin Diabetes Center /articles/diabetes-in-a-dish-model-uncovers-new-insights-into-the-cause-of-type-2-diabetes/?sc=rsin /articles/diabetes-in-a-dish-model-uncovers-new-insights-into-the-cause-of-type-2-diabetes/?sc=rsin Thu, 03 Sep 2020 11:45:08 EST Researchers have developed a novel 'disease-in-a-dish' model to study the basic molecular factors that lead to the development of type 2 diabetes, uncovering the potential existence of major signaling defects both inside and outside of the classical insulin signaling cascade, and providing new perspectives on the mechanisms behind insulin resistance in type 2 diabetes and possibly opportunities for the development of novel therapeutics for the disease. Joslin Diabetes Center /articles/transplanted-brown-fat-like-cells-hold-promise-for-obesity-and-diabetes/?sc=rsin /articles/transplanted-brown-fat-like-cells-hold-promise-for-obesity-and-diabetes/?sc=rsin Wed, 26 Aug 2020 14:15:37 EST A potential therapy for obesity would transplant HUMBLE (human brown-like) fat cells, human white fat cells that have been genetically modified using CRISPR to become similar to heat-generating brown fat cells. Joslin Diabetes Center /articles/increased-blood-sugar-levels-may-decrease-benefits-of-aerobic-exercise/?sc=rsin /articles/increased-blood-sugar-levels-may-decrease-benefits-of-aerobic-exercise/?sc=rsin Mon, 20 Jul 2020 12:45:03 EST Researchers at Joslin Diabetes Center have discovered that some benefits of aerobic exercise may be dampened by higher-than-normal blood sugar levels, and that this is independent of obesity and insulin levels in the blood. Joslin Diabetes Center