Latest news from Children's Hospital of Philadelphia on Newswise en-us Copyright 2025 Newswise 115 31 / /images/newswise-logo-rss.gif /articles/children-s-hospital-of-philadelphia-experts-unveil-innovative-fetal-medicine-data-platform/?sc=rsin /articles/children-s-hospital-of-philadelphia-experts-unveil-innovative-fetal-medicine-data-platform/?sc=rsin Tue, 28 Jan 2025 11:00:04 EST An interprofessional team at Children's Hospital of Philadelphia is transforming CHOP's approach to fetal medicine through a first-of-its-kind data integration platform. The Clinical Outcomes Data Archive (CODA) platform offers clinicians real-time data to help inform earlier interventions and treatment strategies in CHOP's Richard D. Wood Jr. Center for Fetal Diagnosis and Treatment (CFDT). A paper outlining CODA's benefits, applications and potential broader impact was recently published in the journal Fetal Diagnosis and Therapy. Children's Hospital of Philadelphia /articles/children-s-hospital-of-philadelphia-researchers-develop-new-tool-with-potential-to-advance-precision-medicine-treatment-for-cancer/?sc=rsin /articles/children-s-hospital-of-philadelphia-researchers-develop-new-tool-with-potential-to-advance-precision-medicine-treatment-for-cancer/?sc=rsin Fri, 03 Jan 2025 19:50:05 EST Researchers at Children's Hospital of Philadelphia (CHOP) and the Perelman School of Medicine at the University of Pennsylvania developed a new screening technology, Aptamer-based T Lymphocyte Activity Screening and SEQuencing (ATLAS-seq), to better identify antigen-reactive T cells that are more likely to offer greater immune responses against cancer cells. Children's Hospital of Philadelphia /articles/first-of-its-kind-gene-therapy-model-offers-hope-for-x-linked-sideroblastic-anemia-treatment/?sc=rsin /articles/first-of-its-kind-gene-therapy-model-offers-hope-for-x-linked-sideroblastic-anemia-treatment/?sc=rsin Thu, 02 Jan 2025 11:30:07 EST Researchers at Children's Hospital of Philadelphia (CHOP) and the University of Pennsylvania Perelman School of Medicine pioneered a first of its kind gene therapy model that offers a potential breakthrough in treating X-linked sideroblastic anemia (XLSA), a rare congenital anemia caused by mutations in the ALAS2 gene crucial for the synthesis of heme, a key compound in hemoglobin. Children's Hospital of Philadelphia /articles/children-s-hospital-of-philadelphia-researchers-find-precision-medicine-treatment-delivers-strong-results-for-infantile-fibrosarcoma-and-other-solid-tumors/?sc=rsin /articles/children-s-hospital-of-philadelphia-researchers-find-precision-medicine-treatment-delivers-strong-results-for-infantile-fibrosarcoma-and-other-solid-tumors/?sc=rsin Mon, 09 Dec 2024 16:15:12 EST Researchers at Children's Hospital of Philadelphia (CHOP) and the Children's Oncology Group (COG) found that larotrectinib, an oral drug that stops cancer-cell growth, was highly effective in pediatric patients with newly diagnosed infantile fibrosarcoma (IFS) or other solid tumors that have a neurotrophic receptor tyrosine kinase (NTRK) gene fusion without a known acquired resistance mutation. The study, published today in the Journal of Clinical Oncology, is the first COG trial to test precision medicine in a front-line setting across all different types of solid tumors based on a genetic biomarker rather than histology. It is poised to redefine the approach to treatment for newly diagnosed fibrosarcoma and other solid tumors with the NTRK gene fusion, potentially reducing or eliminating the need for these patients to receive chemotherapy. Children's Hospital of Philadelphia /articles/children-s-hospital-of-philadelphia-researchers-find-rotavirus-vaccine-is-safe-for-use-in-nicu-babies/?sc=rsin /articles/children-s-hospital-of-philadelphia-researchers-find-rotavirus-vaccine-is-safe-for-use-in-nicu-babies/?sc=rsin Mon, 09 Dec 2024 00:05:00 EST Researchers found that transmission of rotavirus vaccine strains in a neonatal intensive care unit (NICU) is rare and without clinical consequences, strongly suggesting that giving the rotavirus vaccine to eligible infants during their hospitalization provides immune benefits that outweigh any risks. The findings could serve as the basis for a change in clinical practice. Children's Hospital of Philadelphia /articles/new-research-from-children-s-hospital-of-philadelphia-to-transform-standard-of-care-across-the-globe-for-newly-diagnosed-children-with-b-cell-acute-lymphoblastic-leukemia/?sc=rsin /articles/new-research-from-children-s-hospital-of-philadelphia-to-transform-standard-of-care-across-the-globe-for-newly-diagnosed-children-with-b-cell-acute-lymphoblastic-leukemia/?sc=rsin Sat, 07 Dec 2024 10:00:32 EST Researchers at Children's Hospital of Philadelphia (CHOP) and the Children's Oncology Group (COG) announced the results of a Phase 3 study that demonstrated adding the bi-specific T-cell engager, blinatumomab, to chemotherapy for newly diagnosed National Cancer Institute (NCI) standard risk (SR) B-cell acute lymphoblastic leukemia (B-ALL) pediatric patients significantly improves survival outcomes. The results were published today in the New England Journal of Medicine and will be presented during the plenary session at the 66th American Society of Hematology (ASH) Annual Meeting & Exposition in San Diego on December 8. Children's Hospital of Philadelphia /articles/children-s-hospital-of-philadelphia-researchers-announce-new-ai-model-for-cell-segmentation-and-classification/?sc=rsin /articles/children-s-hospital-of-philadelphia-researchers-announce-new-ai-model-for-cell-segmentation-and-classification/?sc=rsin Mon, 25 Nov 2024 10:00:25 EST Researchers at Children's Hospital of Philadelphia (CHOP) announced the creation of a new AI technology called CelloType, a comprehensive model designed to more accurately identify and classify cells in high-content tissue images. Children's Hospital of Philadelphia /articles/children-s-hospital-of-philadelphia-recognizes-five-chop-physicians-selected-to-join-the-american-pediatric-society-in-2025/?sc=rsin /articles/children-s-hospital-of-philadelphia-recognizes-five-chop-physicians-selected-to-join-the-american-pediatric-society-in-2025/?sc=rsin Tue, 19 Nov 2024 15:00:04 EST The APS will recognize its new members at its Presidential Plenary at the Pediatric Academic Societies 2025 Meeting in April. Current members nominate new members by recognizing individuals who have distinguished themselves as child health leaders, clinicians, policymakers, researchers, scholars and teachers. Children's Hospital of Philadelphia /articles/children-s-hospital-of-philadelphia-researchers-announce-promising-results-from-first-of-its-kind-multicenter-phase-1-gene-therapy-trial-for-danon-disease/?sc=rsin /articles/children-s-hospital-of-philadelphia-researchers-announce-promising-results-from-first-of-its-kind-multicenter-phase-1-gene-therapy-trial-for-danon-disease/?sc=rsin Mon, 18 Nov 2024 11:55:51 EST Researchers at Children's Hospital of Philadelphia (CHOP) announced encouraging results from the first ever gene therapy trial for Danon disease (DD), a rare, X-linked heart condition caused by a single gene mutation. The phase 1 trial was a collaboration between CHOP and the University of California, San Diego Medical Center, the University of Colorado, Anschutz Medical Center, Boston Children's Hospital and Rocket Pharmaceuticals. The data on the results of the RP-A501 Phase 1 trial, presented at a late breaking session today at the American Heart Association Scientific Sessions 2024 in Chicago, were also published in the New England Journal of Medicine. Children's Hospital of Philadelphia /articles/children-s-hospital-of-philadelphia-s-center-for-data-driven-discovery-in-biomedicine-receives-up-to-10-million-arpa-h-award-to-create-tool-for-sharing-data-on-cancer-and-rare-diseases/?sc=rsin /articles/children-s-hospital-of-philadelphia-s-center-for-data-driven-discovery-in-biomedicine-receives-up-to-10-million-arpa-h-award-to-create-tool-for-sharing-data-on-cancer-and-rare-diseases/?sc=rsin Wed, 09 Oct 2024 10:00:43 EST A multi-institutional program led by researchers at the Center for Data Driven Discovery in Biomedicine (D3B) at Children's Hospital of Philadelphia (CHOP) has received up to $10 million Advanced Research Projects Agency for Health (APRA-H) Mission Office Innovative Solutions Openings award to research, validate and implement a new model for sharing and integrating data at a national level. Children's Hospital of Philadelphia /articles/researchers-at-children-s-hospital-of-philadelphia-reveal-new-insights-into-non-inflammatory-causes-of-rare-neurological-symptoms-in-children-adolescents-and-young-adults-following-car-t-therapy/?sc=rsin /articles/researchers-at-children-s-hospital-of-philadelphia-reveal-new-insights-into-non-inflammatory-causes-of-rare-neurological-symptoms-in-children-adolescents-and-young-adults-following-car-t-therapy/?sc=rsin Mon, 07 Oct 2024 14:05:40 EST Researchers at Children's Hospital of Philadelphia (CHOP) revealed for the first time that children, adolescents and young adults may experience very rare neurological issues of paraparesis and quadriparesis following chimeric antigen receptor T-cell (CAR-T) therapy, a type of immunotherapy used to treat B-cell Acute Lymphoblastic Leukemia (B-ALL). Children's Hospital of Philadelphia /articles/chop-pediatrician-tips-on-smart-phone-use-an-essential-back-to-school-guide/?sc=rsin /articles/chop-pediatrician-tips-on-smart-phone-use-an-essential-back-to-school-guide/?sc=rsin Thu, 05 Sep 2024 14:00:37 EST Children's Hospital of Philadelphia /articles/researchers-at-children-s-hospital-of-philadelphia-advocate-for-energy-drink-regulation/?sc=rsin /articles/researchers-at-children-s-hospital-of-philadelphia-advocate-for-energy-drink-regulation/?sc=rsin Wed, 04 Sep 2024 13:05:45 EST Children's Hospital of Philadelphia /articles/many-youths-continue-to-take-opioids-months-after-surgical-procedures/?sc=rsin /articles/many-youths-continue-to-take-opioids-months-after-surgical-procedures/?sc=rsin Thu, 11 Jul 2024 09:05:24 EST A multi-institutional study found that 1 in 6 youths fill an opioid prescription prior to surgery, and 3% of patients were still filling opioid prescriptions three to six months after surgery, indicating persistent opioid use and possible opioid dependence. Children's Hospital of Philadelphia /articles/children-s-hospital-of-philadelphia-researchers-find-parent-and-caregiver-support-linked-to-decreased-depression-and-suicidal-thoughts-in-lgbtq-and-non-lgbtq-youth/?sc=rsin /articles/children-s-hospital-of-philadelphia-researchers-find-parent-and-caregiver-support-linked-to-decreased-depression-and-suicidal-thoughts-in-lgbtq-and-non-lgbtq-youth/?sc=rsin Thu, 11 Jul 2024 09:05:01 EST A new study from researchers found that LGBTQ+ youth were more likely to experience depression and thoughts and attempts of suicide than non-LGBTQ+ youth, yet the prevalence of these mental health symptoms were significantly reduced when LGBTQ+ youths reported support from their parents. Children's Hospital of Philadelphia /articles/children-s-hospital-of-philadelphia-researchers-find-elementary-age-children-experience-more-concussions-during-activities-unrelated-to-sports/?sc=rsin /articles/children-s-hospital-of-philadelphia-researchers-find-elementary-age-children-experience-more-concussions-during-activities-unrelated-to-sports/?sc=rsin Thu, 27 Jun 2024 12:05:46 EST Researchers found that young children between the ages of 5 and 12 were more likely to experience a concussion from recreation and other non-sport activities, yet those injuries were not seen by specialists until days later compared with sports-related concussions in the same age group. Children's Hospital of Philadelphia /articles/chop-developed-adolescent-health-questionnaire-helps-doctors-and-families-navigate-complex-issues/?sc=rsin /articles/chop-developed-adolescent-health-questionnaire-helps-doctors-and-families-navigate-complex-issues/?sc=rsin Thu, 13 Jun 2024 10:05:00 EST While doctors understand that adolescents have certain unique health questions and concerns, several challenges prevent this critical information from being collected in a systematic way and providing appropriate referrals across a wide group of patients. Children's Hospital of Philadelphia /articles/chop-researchers-develop-easy-to-use-screening-tool-to-help-improve-family-access-to-federal-nutrition-programs/?sc=rsin /articles/chop-researchers-develop-easy-to-use-screening-tool-to-help-improve-family-access-to-federal-nutrition-programs/?sc=rsin Thu, 30 May 2024 00:05:45 EST Researchers developed, implemented and successfully tested a nutrition screener to improve access to healthy resources for families eligible for federally funded food benefits. Children's Hospital of Philadelphia /articles/chop-researchers-identify-causal-genetic-variant-linked-to-common-childhood-obesity/?sc=rsin /articles/chop-researchers-identify-causal-genetic-variant-linked-to-common-childhood-obesity/?sc=rsin Wed, 01 May 2024 11:00:00 EST Researchers have identified a causal genetic variant strongly associated with childhood obesity. The study provides new insight into the importance of the hypothalamus of the brain and its role in common childhood obesity and the target gene may serve as a druggable target for future therapeutic interventions. Children's Hospital of Philadelphia /articles/researchers-publish-final-results-of-key-clinical-trial-for-gene-therapy-for-sickle-cell-disease/?sc=rsin /articles/researchers-publish-final-results-of-key-clinical-trial-for-gene-therapy-for-sickle-cell-disease/?sc=rsin Wed, 24 Apr 2024 17:00:00 EST An international consortium published the final results of a key clinical trial of the gene therapy CASGEVY (exagamglogene autotemcel) for the treatment of sickle cell disease in patients 12 years and older with recurrent vaso-occlusive crises (VOCs). Children's Hospital of Philadelphia