display Latest news from Perelman School of Medicine at the University of Pennsylvania on Newswise en-us Copyright 2024 Newswise 115 31 / /images/newswise-logo-rss.gif /articles/researchers-uncover-new-infection-fighting-molecules-through-molecular-de-extinction/?sc=rsin /articles/researchers-uncover-new-infection-fighting-molecules-through-molecular-de-extinction/?sc=rsin Wed, 11 Sep 2024 11:00:00 EST Perelman School of Medicine at the University of Pennsylvania /articles/100x-improvement-in-sight-seen-after-gene-therapy-trial/?sc=rsin /articles/100x-improvement-in-sight-seen-after-gene-therapy-trial/?sc=rsin Thu, 05 Sep 2024 18:30:00 EST The vision of people with a rare inherited condition that causes them to lose much of their sight early in childhood was 100 times better after they received gene therapy to address the genetic mutation causing it. Some patients even experienced a 10,000-fold improvement in their vision after receiving the highest dose of the therapy, according to researchers from the Perelman School of Medicine at the University of Pennsylvania who co-led the clinical trial published in The Lancet. Perelman School of Medicine at the University of Pennsylvania /articles/penn-study-finds-taking-semaglutide-for-weight-management-does-not-increase-risk-of-depression-or-suicidal-behavior-in-people-without-known-major-psychopathology/?sc=rsin /articles/penn-study-finds-taking-semaglutide-for-weight-management-does-not-increase-risk-of-depression-or-suicidal-behavior-in-people-without-known-major-psychopathology/?sc=rsin Tue, 03 Sep 2024 11:00:00 EST Taking the weight loss medication semaglutide did not increase the risk of depressive symptoms, suicidal thoughts, or suicidal behavior in persons without known major mental health disorders, according to a new study led by researchers from the Perelman School of Medicine at the University of Pennsylvania published this week in JAMA Internal Medicine. Both the Food and Drug Administration (FDA) and the European Medicines Agency are actively monitoring the psychiatric safety of semaglutide and similar medications after post marketing surveillance reports of depression, suicidal thoughts (ideation), and suicidal behavior in patients taking the drugs for the management of type 2 diabetes or obesity. Perelman School of Medicine at the University of Pennsylvania /articles/combo-immunotherapy-produces-distinct-waves-of-cancer-fighting-t-cells-with-each-dose/?sc=rsin /articles/combo-immunotherapy-produces-distinct-waves-of-cancer-fighting-t-cells-with-each-dose/?sc=rsin Thu, 29 Aug 2024 11:00:00 EST A new tool for monitoring immune health patterns over time reveals how a pair of checkpoint inhibitor therapies works together to recruit new cancer-fighting T cells with every infusion. Perelman School of Medicine at the University of Pennsylvania /articles/keeping-calm-in-case-of-catastrophe/?sc=rsin /articles/keeping-calm-in-case-of-catastrophe/?sc=rsin Wed, 28 Aug 2024 13:05:26 EST The small but dedicated Hospital Emergency Response Team works year-round to imagine and prepare for major crises that could disrupt patient care. Perelman School of Medicine at the University of Pennsylvania /articles/breaking-through-the-mysteries-of-predicting-coma-recovery/?sc=rsin /articles/breaking-through-the-mysteries-of-predicting-coma-recovery/?sc=rsin Wed, 28 Aug 2024 13:05:05 EST Predicting a patient's recovery from a coma has profound implications. Neurologist David Fischer, MD, is building the infrastructure to get it right. Perelman School of Medicine at the University of Pennsylvania /articles/penn-medicine-and-parker-institute-renew-alliance-to-continue-advancing-groundbreaking-cancer-immunotherapy-research/?sc=rsin /articles/penn-medicine-and-parker-institute-renew-alliance-to-continue-advancing-groundbreaking-cancer-immunotherapy-research/?sc=rsin Wed, 21 Aug 2024 10:05:16 EST The University of Pennsylvania and the Parker Institute for Cancer Immunotherapy (PICI) have renewed their collaboration to advance cancer immunotherapy research at Penn Medicine's Abramson Cancer Center (ACC). Perelman School of Medicine at the University of Pennsylvania /articles/brain-aging-patterns-in-a-large-and-diverse-cohort-of-49-482-individuals/?sc=rsin /articles/brain-aging-patterns-in-a-large-and-diverse-cohort-of-49-482-individuals/?sc=rsin Thu, 15 Aug 2024 14:05:12 EST Perelman School of Medicine at the University of Pennsylvania /articles/to-get-drivers-to-put-down-their-phones-make-it-a-game/?sc=rsin /articles/to-get-drivers-to-put-down-their-phones-make-it-a-game/?sc=rsin Mon, 29 Jul 2024 14:05:05 EST A large trial of strategies to reduce distracted driving showed that those that were "gamified" yielded a lasting reduction in handheld phone usage while driving Perelman School of Medicine at the University of Pennsylvania /articles/penn-researchers-reveal-how-a-bacterium-supports-healing-of-chronic-diabetic-wounds/?sc=rsin /articles/penn-researchers-reveal-how-a-bacterium-supports-healing-of-chronic-diabetic-wounds/?sc=rsin Thu, 25 Jul 2024 12:05:05 EST There are many important reasons for keeping cuts and sores clean, but new research from the Perelman School of Medicine at the University of Pennsylvania shows that a certain can facilitate healing of hard-to-treat wounds among people with diabetes. Perelman School of Medicine at the University of Pennsylvania /articles/knockout-of-cd5-on-car-t-cells-boosts-anti-tumor-efficacy/?sc=rsin /articles/knockout-of-cd5-on-car-t-cells-boosts-anti-tumor-efficacy/?sc=rsin Mon, 22 Jul 2024 09:05:51 EST The effectiveness of CAR T cell therapy against a variety of cancers, including solid tumors, could be boosted greatly by using CRISPR-Cas9 technology to knock out the gene for CD5, a protein found on the surface of T cells, according to a preclinical study from investigators at the University of Pennsylvania's Perelman School of Medicine and Abramson Cancer Center. Perelman School of Medicine at the University of Pennsylvania /articles/genetic-study-highlights-importance-of-diversity-in-understanding-health-disparities/?sc=rsin /articles/genetic-study-highlights-importance-of-diversity-in-understanding-health-disparities/?sc=rsin Thu, 18 Jul 2024 14:00:00 EST The majority of genetic studies focus on people of European descent, which limits the understanding of how genes influence health in other populations. Perelman School of Medicine at the University of Pennsylvania /articles/when-there-s-money-to-lose-phone-usage-while-driving-drops/?sc=rsin /articles/when-there-s-money-to-lose-phone-usage-while-driving-drops/?sc=rsin Wed, 10 Jul 2024 11:00:00 EST Researchers discovered that feedback plus cash incentives designed with insights from behavioral science reduces phone use while driving Perelman School of Medicine at the University of Pennsylvania /articles/new-form-of-repetitive-magnetic-brain-stimulation-reduces-treatment-time-for-bipolar-disorder/?sc=rsin /articles/new-form-of-repetitive-magnetic-brain-stimulation-reduces-treatment-time-for-bipolar-disorder/?sc=rsin Wed, 10 Jul 2024 11:00:00 EST A potential new treatment for bipolar disorder (BP) that significantly shortens treatment time has emerged, following a randomized clinical trial using accelerated intermittent theta burst stimulation (aiTBS). While current theta burst stimulation (TBS) treatments can take between four and six weeks to administer, this new technique reduces treatment to five days. Perelman School of Medicine at the University of Pennsylvania /articles/extended-release-7-day-injectable-buprenorphine-for-patients-with-minimal-to-mild-opioid-withdrawal/?sc=rsin /articles/extended-release-7-day-injectable-buprenorphine-for-patients-with-minimal-to-mild-opioid-withdrawal/?sc=rsin Mon, 08 Jul 2024 14:05:45 EST Perelman School of Medicine at the University of Pennsylvania /articles/expert-available-fda-approval-of-alzheimer-s-disease-drug-donanemab/?sc=rsin /articles/expert-available-fda-approval-of-alzheimer-s-disease-drug-donanemab/?sc=rsin Tue, 02 Jul 2024 15:05:50 EST Perelman School of Medicine at the University of Pennsylvania /articles/clinician-and-patient-directed-communication-strategies-for-patients-with-cancer-at-high-mortality-risk/?sc=rsin /articles/clinician-and-patient-directed-communication-strategies-for-patients-with-cancer-at-high-mortality-risk/?sc=rsin Mon, 01 Jul 2024 13:05:22 EST Perelman School of Medicine at the University of Pennsylvania /articles/penn-researchers-will-investigate-link-between-tbi-and-dementia-with-10m-nih-grant/?sc=rsin /articles/penn-researchers-will-investigate-link-between-tbi-and-dementia-with-10m-nih-grant/?sc=rsin Fri, 28 Jun 2024 12:05:47 EST An international team of researchers led by Penn Medicine will investigate the link between traumatic brain injuries (TBI) and Alzheimer's disease and related dementias (ADRD) over the next five years with a $10 million grant from the National Institute of Neurological Disorders and Stroke (NINDS). Perelman School of Medicine at the University of Pennsylvania /articles/hyperhomocysteinemia-is-associated-with-a-myriad-of-age-related-illnesses-a-potential-role-for-metal-toxicity/?sc=rsin /articles/hyperhomocysteinemia-is-associated-with-a-myriad-of-age-related-illnesses-a-potential-role-for-metal-toxicity/?sc=rsin Thu, 27 Jun 2024 10:05:58 EST Perelman School of Medicine at the University of Pennsylvania /articles/penn-study-finds-better-survival-rates-for-recipients-of-lungs-from-hospital-based-donor-care-units-compared-to-independent-donor-care-units/?sc=rsin /articles/penn-study-finds-better-survival-rates-for-recipients-of-lungs-from-hospital-based-donor-care-units-compared-to-independent-donor-care-units/?sc=rsin Tue, 25 Jun 2024 11:00:00 EST A new study by Penn researchers examined, for the first time, the differences in lung transplant graft outcomes from organs recovered from the two types of deceased organ donor care facilities operating in the United States. Perelman School of Medicine at the University of Pennsylvania