Latest news from Institute for Research in Biomedicine Barcelona on Newswise en-us Copyright 2024 Newswise 115 31 / /images/newswise-logo-rss.gif /articles/key-mechanism-in-embryonic-development-revealed-pivotal-role-of-dna-copy-number/?sc=rsin /articles/key-mechanism-in-embryonic-development-revealed-pivotal-role-of-dna-copy-number/?sc=rsin Wed, 19 Jul 2023 08:10:41 EST Led by Dr. Jordi Casanova and Dr. Panagiotis Giannios, a team of researchers at IRB Barcelona and IBMB(CSIC) has revealed the relationship between autophagy and polyploidy, the latter a phenomenon in which cells contain multiple copies of genetic material. In this regard, they have discovered a scenario where the level of autophagy is much higher in cells with several copies of DNA and that it can even trigger this programmed cell death. Institute for Research in Biomedicine Barcelona /articles/development-of-new-p38-protein-inhibitors-with-therapeutic-potential-for-some-heart-diseases/?sc=rsin /articles/development-of-new-p38-protein-inhibitors-with-therapeutic-potential-for-some-heart-diseases/?sc=rsin Thu, 13 Jul 2023 08:15:46 EST A multidisciplinary team led by Dr. Angel R. Nebreda, Dr. Maria J. Macias and Dr. Modesto Orozco, all at IRB Barcelona, has developed a new type of p38 inhibitor, which preferentially impairs one of the activation pathways of this protein. In particular, these inhibitors block the self-activation (or autophosphorylation) of p38 but allow it to continue to be activated by other mechanisms. Institute for Research in Biomedicine Barcelona /articles/the-structure-of-a-protein-bound-to-dna-reveals-how-the-toxicity-of-the-cholera-bacterium-is-activated/?sc=rsin /articles/the-structure-of-a-protein-bound-to-dna-reveals-how-the-toxicity-of-the-cholera-bacterium-is-activated/?sc=rsin Tue, 11 Jul 2023 08:20:48 EST A team led by Dr. Miquel Coll at the Institute for Research in Biomedicine (IRB Barcelona) and the Institute of Molecular Biology of Barcelona (IBMB-CSIC), in collaboration with researchers led by Dr. Eric Krukonis at the University of Detroit Mercy in the USA, has revealed the atomic structure of the ToxR protein bound to the DNA of two promoters of the genes that cause the virulence of this bacterium. Institute for Research in Biomedicine Barcelona /articles/scientists-unveil-the-mechanism-behind-intracellular-connection-mitofusin-2-is-the-lock-and-key/?sc=rsin /articles/scientists-unveil-the-mechanism-behind-intracellular-connection-mitofusin-2-is-the-lock-and-key/?sc=rsin Wed, 28 Jun 2023 08:20:24 EST Researchers at IRB Barcelona, the University of Barcelona (UB), VIMM, and the University of Padua unveil the key role of Mitofusin 2 cellular makeup in interconnecting organelles within cells. As essential structures with specialized functions, these organelles rely on intricate connections for seamless communication. Among these organelles, mitochondria (known as cell powerhouses) and the endoplasmic reticulum (responsible for protein and lipid synthesis) engage in vital exchanges. Institute for Research in Biomedicine Barcelona /articles/cooperation-between-muscle-and-liver-circadian-clocks-key-to-controlling-glucose-metabolism/?sc=rsin /articles/cooperation-between-muscle-and-liver-circadian-clocks-key-to-controlling-glucose-metabolism/?sc=rsin Mon, 26 Jun 2023 18:00:00 EST Collaborative work by teams at the Department of Medicine and Life Sciences (MELIS) ​​at Pompeu Fabra University (UPF), University of California, Irvine (UCI), and the Institute for Research in Biomedicine (IRB Barcelona) has shown that interplay between circadian clocks in liver and skeletal muscle controls glucose metabolism. Institute for Research in Biomedicine Barcelona /articles/the-il-17-protein-plays-a-key-role-in-skin-ageing/?sc=rsin /articles/the-il-17-protein-plays-a-key-role-in-skin-ageing/?sc=rsin Thu, 08 Jun 2023 11:00:00 EST A team of scientists from the Institute for Research in Biomedicine (IRB Barcelona) in collaboration with the National Center for Genomic Analysis (CNAG) has discovered that IL-17 protein plays a central role in skin ageing. The study, which was led by Dr. Guiomar Solanas, Dr. Salvador Aznar Benitah, both at IRB Barcelona, ​​and Dr. Holger Heyn, at CNAG, highlights an IL-17-mediated ageing process to an inflammatory state. Institute for Research in Biomedicine Barcelona /articles/simulation-tools-drive-the-new-generation-of-therapies-based-on-gene-silencing/?sc=rsin /articles/simulation-tools-drive-the-new-generation-of-therapies-based-on-gene-silencing/?sc=rsin Wed, 17 May 2023 05:05:44 EST Proteins are large, complex molecules that play many critical roles in the body and are produced following the instructions encoded in DNA. By reading their DNA letters, cells produce an intermediate RNA molecule that will give rise to the corresponding protein. Most diseases occur with altered protein levels, which are either a cause or consequence of the condition itself. RNA plays a pivotal role in diseases with altered protein levels by serving as the intermediary messenger between DNA and protein. Institute for Research in Biomedicine Barcelona