Latest news from Nature Communications on Newswise en-us Copyright 2024 Newswise 115 31 / /images/newswise-logo-rss.gif /articles/spatial-epitranscriptomics-reveals-a-to-i-editome-specific-to-cancer-nbsp-stem-cell-nbsp-microniches/?sc=rsin /articles/spatial-epitranscriptomics-reveals-a-to-i-editome-specific-to-cancer-nbsp-stem-cell-nbsp-microniches/?sc=rsin Fri, 13 May 2022 05:45:10 EST ... With Select-seq, we analyse the cancer stem cell-like microniches in relation to the tumour microenvironment of triple-negative breast cancer patients. We identify alternative splice variants, perform complementarity-determining region analysis of ... Nature Communications /articles/a-foxa2-long-term-nbsp-stem-cell-nbsp-population-is-necessary-for-growth-plate-cartilage-regeneration-after-injury/?sc=rsin /articles/a-foxa2-long-term-nbsp-stem-cell-nbsp-population-is-necessary-for-growth-plate-cartilage-regeneration-after-injury/?sc=rsin Tue, 10 May 2022 05:00:53 EST ... reside in the RZ, a known location for stem cells 5,11 , and that FoxA2+ cells are located in close proximity to the SOC, which is viewed as a signaling center of RZ stemness 10 , we asked whether FoxA2+ cells are different than the previously ... Nature Communications /articles/an-instantly-fixable-and-self-adaptive-scaffold-for-skull-regeneration-by-autologous-nbsp-stem-cell-nbsp-recruitment-and-angiogenesis/?sc=rsin /articles/an-instantly-fixable-and-self-adaptive-scaffold-for-skull-regeneration-by-autologous-nbsp-stem-cell-nbsp-recruitment-and-angiogenesis/?sc=rsin Tue, 10 May 2022 05:00:10 EST Limited stem cells, poor stretchability and mismatched interface fusion have plagued the reconstruction of cranial defects by cell-free scaffolds. Here, we designed an instantly fixable and self-adaptive scaffold by dopamine-modified hyaluronic acid ... Nature Communications /articles/ascl1-activates-neuronal-nbsp-stem-cell-like-lineage-programming-through-remodeling-of-the-chromatin-landscape-in-prostate-cancer/?sc=rsin /articles/ascl1-activates-neuronal-nbsp-stem-cell-like-lineage-programming-through-remodeling-of-the-chromatin-landscape-in-prostate-cancer/?sc=rsin Mon, 02 May 2022 08:00:40 EST ... ASCL1 is required to establish the neuronal and stem cell-like lineage ... To determine whether ASCL1 is required for the development of neuronal and stem cell-like phenotype... neuronal and stem cell differentiation and functions to bias the cell fate ... Nature Communications /articles/znf117-regulates-glioblastoma-nbsp-stem-cell-nbsp-differentiation-towards-oligodendroglial-lineage/?sc=rsin /articles/znf117-regulates-glioblastoma-nbsp-stem-cell-nbsp-differentiation-towards-oligodendroglial-lineage/?sc=rsin Mon, 25 Apr 2022 04:00:19 EST ... d Stem cell frequency of GS5 cells treated with Cas9 and the indicated sgRNAs as determined by limiting dilution assay. e-g Representative flow cytometry images (e) and corresponding quantification (f) (n = 3 biologically independent samples, black ... Nature Communications /articles/differential-effects-of-macrophage-subtypes-on-sars-cov-2-infection-in-a-human-pluripotent-nbsp-stem-cell-derived-model/?sc=rsin /articles/differential-effects-of-macrophage-subtypes-on-sars-cov-2-infection-in-a-human-pluripotent-nbsp-stem-cell-derived-model/?sc=rsin Mon, 25 Apr 2022 02:10:35 EST ... In this study, we generate lung cells and macrophages from the same human pluripotent stem cell (hPSC) lines and pair them to establish a co-culture system. This strategy addresses a common concern about histocompatibility when studying ... Nature Communications /articles/astroblastomas-exhibit-radial-glia-nbsp-stem-cell-nbsp-lineages-and-differential-expression-of-imprinted-and-x-inactivation-escape-genes/?sc=rsin /articles/astroblastomas-exhibit-radial-glia-nbsp-stem-cell-nbsp-lineages-and-differential-expression-of-imprinted-and-x-inactivation-escape-genes/?sc=rsin Mon, 25 Apr 2022 02:10:30 EST ... ABCC1 encodes the ATPase cassette transporter protein multidrug resistance 1, a stem cell marker and MYCN transcriptional target conferring ... 1, 2), suggesting they share a common ependymal stem cell lineage. The mismatch repair gene ... Nature Communications /articles/single-cell-analyses-identify-a-highly-regenerative-and-homogenous-human-cd34-hematopoietic-nbsp-stem-cell-nbsp-population/?sc=rsin /articles/single-cell-analyses-identify-a-highly-regenerative-and-homogenous-human-cd34-hematopoietic-nbsp-stem-cell-nbsp-population/?sc=rsin Mon, 25 Apr 2022 02:10:16 EST The heterogeneous nature of human CD34+ hematopoietic stem cells (HSCs) has hampered our understanding of the cellular and molecular trajectories that HSCs navigate during lineage commitment. Using various platforms including single cell ... Nature Communications /articles/cpeb1-directs-muscle-nbsp-stem-cell-nbsp-activation-by-reprogramming-the-translational-landscape/?sc=rsin /articles/cpeb1-directs-muscle-nbsp-stem-cell-nbsp-activation-by-reprogramming-the-translational-landscape/?sc=rsin Tue, 22 Feb 2022 05:00:55 EST ... through the regulation of p27Kip1 mRNA translation and modulates glioma stem cell differentiation via regulating Hes1 and Sirt1 translation 36,... may be a potential Aurka downstream target, regulating SC function with regards to stem cell self-renewal ... Nature Communications /articles/enhanced-germline-nbsp-stem-cell-nbsp-longevity-in-drosophila-diapause/?sc=rsin /articles/enhanced-germline-nbsp-stem-cell-nbsp-longevity-in-drosophila-diapause/?sc=rsin Mon, 14 Feb 2022 08:00:18 EST ... We were surprised to find that GSCs are not maintained in a stem cell state during diapause, even though ovaries can rebound post-diapause to youthful stem cell numbers, proliferation, and ovary size. This remarkable recovery potential appears ... Nature Communications /articles/generation-of-the-organotypic-kidney-structure-by-integrating-pluripotent-nbsp-stem-cell-derived-renal-stroma/?sc=rsin /articles/generation-of-the-organotypic-kidney-structure-by-integrating-pluripotent-nbsp-stem-cell-derived-renal-stroma/?sc=rsin Mon, 07 Feb 2022 03:00:08 EST ... Recent progress in stem cell biology has enabled the generation of "organoids" from pluripotent stem cells (PSCs), but most of the currently available organoids lack the organotypic "higher-order structure", in which functional units are distributed at ... Nature Communications /articles/cholinergic-signals-preserve-haematopoietic-nbsp-stem-cell-nbsp-quiescence-during-regenerative-haematopoiesis/?sc=rsin /articles/cholinergic-signals-preserve-haematopoietic-nbsp-stem-cell-nbsp-quiescence-during-regenerative-haematopoiesis/?sc=rsin Fri, 04 Feb 2022 12:00:41 EST ... to increased CXCL12 expression and haematopoietic stem cell quiescence. Consequently, nicotine exposure increases endosteal haematopoietic stem cell quiescence in vivo and impairs hematopoietic regeneration after haematopoietic ... Nature Communications