Newswise News from Stem Cell Research & Therapy

Hypoxic mesenchymal stem cell-derived extracellular vesicles ameliorate renal fibrosis after ischemia-reperfusion injure by restoring CPT1A mediated fatty acid oxidation

Stem Cell Research & Therapy — Thu, 12 May 2022 05:00:37 EST

Renal fibrosis is a common pathological process of chronic kidney diseases induced by multiple factors. Hypoxic pretreatment of mesenchymal stem cells can enhance the efficacy of secreted extracellular vesicles (MSC-EVs) on various diseases, but it ...

Molecular regulation of trophoblast stem cell self-renewal and giant cell differentiation by the Hippo components YAP and LATS1

Stem Cell Research & Therapy — Wed, 11 May 2022 05:00:45 EST

... has led to the development of trophoblast stem cell lines which retain the capacity to ... -OFF switch to regulate various hallmark processes of stem cell biology like self-renewal [15, 16... pools with temporal replenishment of the trophoblast stem cell hub ...

Function of epithelial stem cell in the repair of alveolar injury

Stem Cell Research & Therapy — Mon, 02 May 2022 08:00:43 EST

... For example, in the repair phase after bacteria (Pseudomonas aeruginosa)-induced lung injury, 30-70% of the AT2s acquire the expression of a stem cell surface marker Sca-1 (stem cell antigen 1, or Ly6a) [15, 16]. The Sca-1 + AT2s are likely to ...

Autologous bone marrow mononuclear cell infusion for liver cirrhosis after the Kasai operation in children with biliary atresia

Stem Cell Research & Therapy — Mon, 14 Mar 2022 12:00:07 EST

To evaluate the safety and early outcomes of autologous bone marrow mononuclear cell (BMMNC) infusion for liver cirrhosis due to biliary atresia (BA) after Kasai operation.

Mid-term prognosis of the stromal vascular fraction for knee osteoarthritis: a minimum 5-year follow-up study

Stem Cell Research & Therapy — Sat, 12 Mar 2022 12:00:52 EST

The short-term safety and efficacy of stromal vascular fraction (SVF) in treating knee osteoarthritis (KOA) have been extensively studied but the mid-term and long-term prognoses remain unknown.

Therapeutic role of uterine-derived stem cells in acute kidney injury

Stem Cell Research & Therapy — Sat, 12 Mar 2022 12:00:45 EST

Acute kidney injury (AKI) causes abrupt deterioration in kidney function that disrupts metabolic, electrolyte and fluid homeostasis. Although the prevalence of AKI is steadily increasing, no definitive treatme...

Integrative analysis reveals a lineage-specific circular RNA landscape for adipo-osteogenesis of human mesenchymal stem cells

Stem Cell Research & Therapy — Sat, 12 Mar 2022 12:00:43 EST

The balance between osteogenesis and adipogenesis of mesenchymal stem cells (MSCs) is critical to skeletal development and diseases. As a research hotspot, circular RNAs (circRNAs) have expanded our understand...

Drug metabolic activity is a critical cell-intrinsic determinant for selection of hepatocytes during long-term culture

Stem Cell Research & Therapy — Sat, 12 Mar 2022 12:00:15 EST

The liver plays an important role in various metabolic processes, including protein synthesis, lipid and drug metabolisms and detoxifications. Primary culture of hepatocytes is used for the understanding of li...

Genetic correction of concurrent α- and β-thalassemia patient-derived pluripotent stem cells by the CRISPR-Cas9 technology

Stem Cell Research & Therapy — Mon, 07 Mar 2022 12:00:53 EST

Thalassemia is a genetic blood disorder characterized by decreased hemoglobin production. Severe anemia can damage organs and severe threat to life safety. Allogeneic transplantation of bone marrow-derived hem...

Shining the light on clinical application of mesenchymal stem cell therapy in autoimmune diseases

Stem Cell Research & Therapy — Mon, 07 Mar 2022 12:00:35 EST

The autoimmune diseases are associated with the host immune system, chronic inflammation, and immune reaction against self-antigens, which leads to the injury and failure of several tissues. The onset of autoi..

Effect of small extracellular vesicles derived from IL-10-overexpressing mesenchymal stem cells on experimental autoimmune uveitis

Stem Cell Research & Therapy — Mon, 07 Mar 2022 12:00:34 EST

Autoimmune uveitis is a sight-threatening intraocular inflammation mainly caused by immune dysregulation. The development of safe and effective therapeutic approaches is urgently needed. Small extracellular

Increased phosphatase regenerating liver-1 trigger vascular remodeling in injured ovary via platelet-derived growth factor signaling pathway

Stem Cell Research & Therapy — Mon, 07 Mar 2022 12:00:26 EST

Vascular abnormalities in the ovary cause infertility accompanied by ovarian insufficiency due to a microenvironment of barren ovarian tissues. Placenta-derived mesenchymal stem cells (PD-MSCs, Naive) treatmen...

Safety and efficacy study of allogeneic human menstrual blood stromal cells secretome to treat severe COVID-19 patients: clinical trial phase I & II

Stem Cell Research & Therapy — Mon, 07 Mar 2022 12:00:24 EST

Cell-free Mesenchymal stromal cells (MSCs) have been considered due to their capacity to modulate the immune system and suppress cytokine storms caused by SARS-CoV-2. This prospective randomized double-blind p...

Mesenchymal stem cells and natural killer cells interaction mechanisms and potential clinical applications

Stem Cell Research & Therapy — Mon, 07 Mar 2022 12:00:20 EST

Natural killer cells (NK cells) are innate immune cells that are activated to fight tumor cells and virus-infected cells. NK cells also play an important role in the graft versus leukemia response. However, th...

Cardiovascular disease (CVD) risk assessment of HIV medication regimens using hematopoietic CD34+ progenitor cells

Stem Cell Research & Therapy — Mon, 07 Mar 2022 12:00:15 EST

To determine the effects of integrase inhibitor (INSTI) in comparison with non-INSTI-based regimens such as non-nucleoside reverse transcriptase inhibitors (NNRTIs)-based regimens on cardiovascular disease (CV...

Adipose-derived stem cells ameliorate atopic dermatitis by suppressing the IL-17 expression of Th17 cells in an ovalbumin-induced mouse model

Stem Cell Research & Therapy — Mon, 07 Mar 2022 12:00:06 EST

Mesenchymal stem cells (MSCs) have therapeutic potential for atopic dermatitis (AD) owing to their immunoregulatory effects. However, the underlying mechanisms associated with the therapeutic efficacy of MSCs ...

Human umbilical cord mesenchymal stem cell promotes angiogenesis via integrin β1/ERK1/2/HIF-1α/VEGF-A signaling pathway for off-the-shelf breast tissue engineering

Stem Cell Research & Therapy — Mon, 07 Mar 2022 12:00:02 EST

Mesenchymal stem cells (MSC)-based tissue engineered breast represent the visible future for breast reconstruction after mastectomy. However, autologous MSCs might not be appropriate for the large graft constr...

Mesenchymal stem cells protect against acetaminophen hepatotoxicity by secreting regenerative cytokine hepatocyte growth factor

Stem Cell Research & Therapy — Fri, 04 Mar 2022 12:00:48 EST

Acetaminophen (APAP) overdose is a major cause of the morbidity of acute liver failure. The current clinically approved treatment for APAP poisoning, N-acetylcysteine (NAC), has a limited therapeutic window, and

Current status of clinical trials assessing mesenchymal stem cell therapy for graft versus host disease: a systematic review

Stem Cell Research & Therapy — Fri, 04 Mar 2022 12:00:16 EST

Graft-versus-host disease (GVHD) is a common fatal complication of hematopoietic stem cell transplantation (HSCT), where steroids are used as a treatment option. However, there are currently no second-line tre...

EPC-EXs improve astrocyte survival and oxidative stress through different uptaking pathways in diabetic hypoxia condition

Stem Cell Research & Therapy — Thu, 03 Mar 2022 12:00:52 EST

Hyperglycemia contributes to cardiovascular complications in patients with type 2 diabetes. We confirmed that high glucose (HG) induces endothelial dysfunction and cerebral ischemic injury is enlarged in diabe...