/institutions/newsroom/ 3507/?source= Latest news from Sanford Burnham Prebys on Newswise en-us Copyright 2022 Newswise 115 31 / /images/newswise-logo-rss.gif /articles/view/773537/?sc=rsin /articles/view/773537/?sc=rsin Mon, 27 Jun 2022 16:30:03 EST Brooke Emerling from Sanford Burnham Prebys has been awarded a new grant from the National Institutes of Health (NIH) to continue her work on cellular signaling in cancer. The four-year, $2.3 million project could accelerate the development of new therapies for a range of cancers, particularly metastatic breast cancer. It also offers an answer to a longstanding mystery in cancer metabolism. Sanford Burnham Prebys /articles/view/767209/?sc=rsin /articles/view/767209/?sc=rsin Tue, 15 Mar 2022 17:10:13 EST With the help of two new grants from the National Institutes of Health totaling more than $4.4 million, Sanford Burnham Prebys professor Charles Spruck, Ph.D., and his team are refining a cutting-edge breast cancer treatment. Sanford Burnham Prebys /articles/view/766075/?sc=rsin /articles/view/766075/?sc=rsin Wed, 23 Feb 2022 16:25:06 EST The 2022 Rare Disease Day Symposium & CDG/NGLY1 Family Conference will take place February 25-27th at the Dana Hotel on Mission Bay in San Diego. Sanford Burnham Prebys /articles/view/765303/?sc=rsin /articles/view/765303/?sc=rsin Wed, 09 Feb 2022 14:15:27 EST Bioinformaticist Kevin Yip, Ph.D., has joined Sanford Burnham Prebys as a professor, where he will collaborate with other faculty across the Institute on large-scale data analysis and develop new tools and models for computational biology. Sanford Burnham Prebys /articles/view/764863/?sc=rsin /articles/view/764863/?sc=rsin Tue, 08 Feb 2022 14:00:00 EST New research from Sanford Burnham Prebys has revealed significant molecular differences between the breast cells of white and Black women that help explain why Black women experience higher breast cancer mortality. The findings, published in the journal Therapeutic Advances in Medical Oncology, suggest that changing current diagnostic and treatment strategies could help address the disparity. Sanford Burnham Prebys /articles/view/764724/?sc=rsin /articles/view/764724/?sc=rsin Tue, 01 Feb 2022 09:00:36 EST Sanford Burnham Prebys professor Yu Yamaguchi has been awarded a $2.9 million grant from the National Institutes of Health to study the role of heparan sulfate (HS) in Alzheimer's disease. HS is a structural molecule found in the scaffolding between cells that has been previously observed to influence the development of Alzheimer's disease. However, the precise function it plays in the brain has not been studied closely. Sanford Burnham Prebys /articles/view/763998/?sc=rsin /articles/view/763998/?sc=rsin Tue, 18 Jan 2022 17:55:48 EST In a phase 2 clinical trial conducted by Avalo Therapeutics and supported by researchers from Sanford Burnham Prebys, a significantly higher proportion of hospitalized patients with COVID-19 remained alive and free of respiratory failure for 28 days after receiving treatment with a new antibody called CERC-002. Unlike other experimental COVID therapies, CERC-002 does not target the virus itself, instead targeting the immune response associated with the virus to stop the disease from progressing before it becomes fatal. Sanford Burnham Prebys /articles/view/763809/?sc=rsin /articles/view/763809/?sc=rsin Thu, 13 Jan 2022 17:35:24 EST Sanford Burnham Prebys professor Andrei Osterman, Ph.D., has been awarded a $3.6 million grant from the National Institutes of Health (NIH) to expand current knowledge of antibiotic resistance, which will inform more precise antibiotic prescribing practices and help researchers develop drugs that are harder for bacteria to resist. Sanford Burnham Prebys /articles/view/762428/?sc=rsin /articles/view/762428/?sc=rsin Fri, 17 Dec 2021 13:00:10 EST Sanford Burnham Prebys is pleased to announce several new appointments to its executive leadership team, fortifying the Institute's position as a world leader in nonprofit biomedical research. Sanford Burnham Prebys /articles/view/760712/?sc=rsin /articles/view/760712/?sc=rsin Tue, 16 Nov 2021 03:05:30 EST Over the last decade, the publications of Jerold Chun and Randal J. Kaufman are among the top 1% in the world for number of citations Sanford Burnham Prebys /articles/view/760711/?sc=rsin /articles/view/760711/?sc=rsin Mon, 15 Nov 2021 15:00:00 EST New research from Sanford Burnham Prebys has revealed features of the aging Down syndrome brain that could help explain why people with Down syndrome almost inevitably get Alzheimer's later in life. Sanford Burnham Prebys /articles/view/760547/?sc=rsin /articles/view/760547/?sc=rsin Thu, 11 Nov 2021 05:00:00 EST Researchers from Sanford Burnham Prebys and the National Cancer Institute have shown that gene editing with CRISPR may select for certain cancer-associated mutations, highlighting the need for caution when using CRISPR therapeutically. Sanford Burnham Prebys /articles/view/758817/?sc=rsin /articles/view/758817/?sc=rsin Tue, 12 Oct 2021 08:35:38 EST Researchers from Sanford Burnham Prebys have discovered a new source of stem cells just outside the liver that could help treat people living with Alagille syndrome, a rare, incurable genetic disorder in which the bile ducts of the liver are absent, leading to severe liver damage and death. The findings, published recently in the journal Hepatology, have extensive biomedical implications for Alagille syndrome and for liver disease in general, including cancer. Sanford Burnham Prebys /articles/view/757899/?sc=rsin /articles/view/757899/?sc=rsin Thu, 23 Sep 2021 14:05:15 EST Sanford Burnham Prebys professor Jamey Marth, Ph.D., has been awarded $13.5 million from the National Heart, Lung, and Blood Institute to continue his team's work on sepsis, a condition that occurs when infectious and pathogenic organisms enter the bloodstream. This five-year award is a continuation of a multi-institution initiative, now totaling $27 million, that Marth began in 2016 with the goal of identifying the molecular basis of sepsis to achieve more effective treatments. Sanford Burnham Prebys /articles/view/757878/?sc=rsin /articles/view/757878/?sc=rsin Thu, 23 Sep 2021 12:40:54 EST Sanford Burnham Prebys professor Peter D. Adams, Ph.D., and Salk Institute professor Gerald Shadel, Ph.D., have been awarded a grant from the NIH's National Institute on Aging for $13 million, funding a five-year project to explore the connection between aging and liver cancer. Sanford Burnham Prebys /articles/view/757840/?sc=rsin /articles/view/757840/?sc=rsin Wed, 22 Sep 2021 18:05:37 EST As part of their larger initiative to understand the effects of space conditions on different organisms, NASA has awarded $2 million to Sanford Burnham Prebys assistant professor Karen Ocorr. The grant will fund a three-year project to study the effects of low gravity on muscle and neuron function in fruit flies and nematode worms aboard the International Space Station. Sanford Burnham Prebys /articles/view/757593/?sc=rsin /articles/view/757593/?sc=rsin Fri, 17 Sep 2021 14:50:49 EST Eric Wang, Ph.D., has joined Sanford Burnham Prebys as an assistant professor in the Tumor Initiation and Maintenance Program. Wang comes to Sanford Burnham Prebys from the Dana-Farber Cancer Institute, where he was a postdoctoral research fellow. Sanford Burnham Prebys /articles/view/757241/?sc=rsin /articles/view/757241/?sc=rsin Mon, 13 Sep 2021 05:00:00 EST A new study led by scientists at Sanford Burnham Prebys has shown that the protein RNF5 plays an unusual role in acute myeloid leukemia (AML). Unlike its expected role, marking aberrant proteins for destruction, RNF5 binds with a second cell protein called RBBP4 to control expression of genes implicated in AML. These findings, published in Nature Communications, have important implications for improving AML patient outcomes. Sanford Burnham Prebys /articles/view/754902/?sc=rsin /articles/view/754902/?sc=rsin Mon, 26 Jul 2021 15:00:00 EST Scientists at Sanford Burnham Prebys have discovered how levels of a protein could be used in the future as a blood-based diagnostic aid for schizophrenia. Sanford Burnham Prebys /articles/view/754432/?sc=rsin /articles/view/754432/?sc=rsin Thu, 15 Jul 2021 17:05:43 EST An international research group, led by Jamey Marth, Ph.D., a professor at Sanford Burnham Prebys, has shown that the Neuraminidase 3 (Neu3) enzyme is responsible for the onset and progression of colitis--a chronic digestive disease caused by inflammation of the colon. Sanford Burnham Prebys