/institutions/view/Children's-Hospital-of-Philadelphia- 235/?source= Latest news from Children's Hospital of Philadelphia on Newswise en-us Copyright 2023 Newswise 115 31 / /images/newswise-logo-rss.gif /articles/children-s-hospital-of-philadelphia-princeton-researchers-identify-novel-genetic-disorder/?sc=rsin /articles/children-s-hospital-of-philadelphia-princeton-researchers-identify-novel-genetic-disorder/?sc=rsin Wed, 26 Apr 2023 14:00:00 EST Researchers have discovered a novel genetic disorder associated with neurodevelopmental differences. The discovery identified the disorder in 21 families from all over the world. Children's Hospital of Philadelphia /articles/researchers-find-earlier-intervention-leads-to-greater-improvements-in-young-children-on-the-autism-spectrum/?sc=rsin /articles/researchers-find-earlier-intervention-leads-to-greater-improvements-in-young-children-on-the-autism-spectrum/?sc=rsin Thu, 13 Apr 2023 12:00:34 EST Researchers have demonstrated that starting intervention coaching parents of autistic toddlers as early as 18 months leads to better gains in language, social communication, and daily living skills. Children's Hospital of Philadelphia /articles/chop-led-study-identifies-two-different-regulatory-t-cell-populations/?sc=rsin /articles/chop-led-study-identifies-two-different-regulatory-t-cell-populations/?sc=rsin Fri, 07 Apr 2023 14:00:00 EST A regulatory class of human T cells descends from two different origins, one that relates to autoimmunity and one that relates to protective immunity, according to a new study led by Children's Hospital of Philadelphia (CHOP). The findings, published today in Science Immunology, could pave the way for new treatments for autoimmune diseases that target the immune system selectively. Children's Hospital of Philadelphia /articles/chop-researchers-use-novel-technique-to-analyze-53-million-points-of-clinical-data/?sc=rsin /articles/chop-researchers-use-novel-technique-to-analyze-53-million-points-of-clinical-data/?sc=rsin Thu, 06 Apr 2023 09:55:49 EST Researchers were able to analyze 53 million patient notes from more than 1.5 million individual patients to identify similarities in their medical histories that can help pinpoint potential risks for developing future diseases and the trajectory of those conditions. This method of identifying phenotypic similarities exceeds the capacity any other current computational models. Children's Hospital of Philadelphia /articles/chop-researchers-reveal-complex-assembly-process-involved-in-dna-virus-replication/?sc=rsin /articles/chop-researchers-reveal-complex-assembly-process-involved-in-dna-virus-replication/?sc=rsin Wed, 05 Apr 2023 11:00:00 EST In a twist on the question, "Which came first, the chicken or the egg?", scientists have long faced a similar question about how human adenovirus replicates: "Which comes first, assembly of the viral particle, or packaging of the viral genome?" Now, in a new study published today in Nature, researchers at Children's Hospital of Philadelphia (CHOP) have answered that question, showing that viral proteins use a process called phase separation to coordinate production of viral progeny. Children's Hospital of Philadelphia /articles/researchers-show-lorlatinib-is-safe-and-effective-for-patients-with-alk-driven-relapsedrefractory-high-risk-neuroblastoma/?sc=rsin /articles/researchers-show-lorlatinib-is-safe-and-effective-for-patients-with-alk-driven-relapsedrefractory-high-risk-neuroblastoma/?sc=rsin Mon, 03 Apr 2023 11:00:00 EST In a significant step for the treatment of neuroblastoma, an international group of researchers led by Children's Hospital of Philadelphia (CHOP), Winship Cancer Institute of Emory University and the New Approaches to Neuroblastoma Therapy (NANT) Consortium has shown that the targeted therapy lorlatinib is safe and effective in treating high-risk neuroblastoma. Children's Hospital of Philadelphia /articles/chop-researchers-develop-first-of-its-kind-prediction-model-for-newborn-seizures/?sc=rsin /articles/chop-researchers-develop-first-of-its-kind-prediction-model-for-newborn-seizures/?sc=rsin Wed, 22 Mar 2023 19:30:00 EST Researchers have developed a prediction model that determines which newborn babies are likely to experience seizures in the Neonatal Intensive Care Unit (NICU). This model could be incorporated into routine care to help the clinical team decide which babies will need electroencephalograms (EEGs) and which babies can be safely managed in the Neonatal Care Unit without monitoring through EEGs. This would allow families and providers to care for babies without intrusive and unnecessary procedures. Children's Hospital of Philadelphia /articles/chop-researchers-find-strong-adolescent-parent-relationships-lead-to-better-long-term-health-outcomes-in-young-adults/?sc=rsin /articles/chop-researchers-find-strong-adolescent-parent-relationships-lead-to-better-long-term-health-outcomes-in-young-adults/?sc=rsin Tue, 21 Mar 2023 11:00:00 EST Researchers have found that adolescents who report strong relationships with their parents have better long-term health outcomes. Study findings suggest that investments in improving parent-adolescent relationships could help improve general health, mental health and sexual, health while also reducing substance use in young adulthood. Children's Hospital of Philadelphia /articles/chop-researchers-find-rate-of-fatal-opioid-poisonings-among-children-more-than-doubled-over-13-year-span/?sc=rsin /articles/chop-researchers-find-rate-of-fatal-opioid-poisonings-among-children-more-than-doubled-over-13-year-span/?sc=rsin Wed, 08 Mar 2023 00:05:00 EST Researchers found opioids were responsible for more than half of all fatal poisonings in children ages 5 and younger, more than double the proportion of fatal poisonings caused by opioids in 2005. Additionally, over-the-counter drugs still contribute to fatal poisonings in this age group despite increased regulation. The findings, published today in the journal Pediatrics, underscore the need for improved intervention to prevent further fatal poisonings. Children's Hospital of Philadelphia /articles/chop-researchers-identify-molecules-that-optimize-immune-presentation-of-antigens-across-the-human-population/?sc=rsin /articles/chop-researchers-identify-molecules-that-optimize-immune-presentation-of-antigens-across-the-human-population/?sc=rsin Fri, 24 Feb 2023 14:00:00 EST Researchers at Children's Hospital of Philadelphia (CHOP) have identified variants of a chaperone molecule that optimizes the binding and presentation of foreign antigens across the human population, which could open the door to numerous applications where robust presentation to the immune system is important, including cell therapy and immunization. The findings were published today in Science Advances. Children's Hospital of Philadelphia /articles/chop-study-finds-multidisciplinary-approach-best-when-assisting-families-with-limited-english-proficiency/?sc=rsin /articles/chop-study-finds-multidisciplinary-approach-best-when-assisting-families-with-limited-english-proficiency/?sc=rsin Thu, 16 Feb 2023 10:05:50 EST Pediatric patients with limited English proficiency (LEP) may face additional challenges when they present to an emergency room. However, researchers found that a multidisciplinary approach helped implement the services of interpreters earlier and significantly improved the identification of these patients to help them receive the care they need. Children's Hospital of Philadelphia /articles/large-study-identifies-risk-factors-in-children-with-chronic-kidney-disease/?sc=rsin /articles/large-study-identifies-risk-factors-in-children-with-chronic-kidney-disease/?sc=rsin Mon, 06 Feb 2023 10:00:48 EST In a new study led by Children's Hospital of Philadelphia (CHOP) and Nemours Children's Health, researchers have overcome the obstacle of scale by analyzing electronic health record data from PEDSnet, a national multicenter pediatric network, to identify a large cohort of children with CKD, evaluate CKD progression, and examine clinical risk factors for kidney function decline. The findings were published in the Clinical Journal of the American Society of Nephrology. Children's Hospital of Philadelphia /articles/chop-researchers-develop-tool-that-reduces-errors-in-stem-cell-transplant-reporting/?sc=rsin /articles/chop-researchers-develop-tool-that-reduces-errors-in-stem-cell-transplant-reporting/?sc=rsin Mon, 23 Jan 2023 14:05:48 EST Researchers at Children's Hospital of Philadelphia (CHOP) have developed a custom-built application to automate determination of engraftment, a key outcome after hematopoietic stem cell transplant (HSCT). The application supersedes a tedious manual process and at the same time substantially improves accuracy of reported hematopoietic cell transplant engraftments. Children's Hospital of Philadelphia /articles/chop-researchers-develop-new-more-accurate-computational-tool-for-long-read-rna-sequencing/?sc=rsin /articles/chop-researchers-develop-new-more-accurate-computational-tool-for-long-read-rna-sequencing/?sc=rsin Fri, 20 Jan 2023 14:00:00 EST Researchers at Children's Hospital of Philadelphia (CHOP) have developed a new computational tool that can more accurately discover and quantify RNA molecules from these error-prone long-read RNA sequencing data. The tool, called ESPRESSO (Error Statistics PRomoted Evaluator of Splice Site Options), was reported today in Science Advances. Children's Hospital of Philadelphia /articles/chop-and-njit-researchers-develop-new-tool-for-studying-multiple-characteristics-of-a-single-cell/?sc=rsin /articles/chop-and-njit-researchers-develop-new-tool-for-studying-multiple-characteristics-of-a-single-cell/?sc=rsin Wed, 21 Dec 2022 10:55:49 EST Researchers from Children's Hospital of Philadelphia (CHOP) and New Jersey Institute of Technology (NJIT) developed new software that integrates a variety of information from a single cell, allowing researchers to see how one change in a cell can lead to several others and providing important clues for pinpointing the exact causes of genetic-based diseases. Children's Hospital of Philadelphia /articles/chop-researchers-identify-potential-genetic-variants-linked-to-increased-cancer-risk-in-children-with-birth-defects/?sc=rsin /articles/chop-researchers-identify-potential-genetic-variants-linked-to-increased-cancer-risk-in-children-with-birth-defects/?sc=rsin Wed, 30 Nov 2022 14:25:42 EST Researchers have identified several genetic variants associated with increased risk of cancer in children with non-chromosomal birth defects, such as congenital heart disease and defects of the central nervous system. While the risk of developing cancer is not as high as children with chromosomal birth defects, it is significantly higher than children with no birth defects at all, and the findings may provide a basis for early detection in these understudied patients. Children's Hospital of Philadelphia /articles/chop-researchers-discover-genetic-variant-associated-with-earlier-onset-childhood-epilepsy/?sc=rsin /articles/chop-researchers-discover-genetic-variant-associated-with-earlier-onset-childhood-epilepsy/?sc=rsin Wed, 30 Nov 2022 14:05:26 EST Researchers have discovered a specific genetic variant in SCN1A, the most common genetic epilepsy, that leads to an earlier onset of epilepsy, with clinical features distinct from other epilepsies. The researchers also identified a potentially effective treatment strategy. Children's Hospital of Philadelphia /articles/chop-led-study-shows-that-antibiotic-resistant-microbes-in-the-gut-make-c-difficile-more-infectious/?sc=rsin /articles/chop-led-study-shows-that-antibiotic-resistant-microbes-in-the-gut-make-c-difficile-more-infectious/?sc=rsin Wed, 16 Nov 2022 11:00:00 EST In a new study in Nature, researchers at Children's Hospital of Philadelphia (CHOP) have found that Enterococcus - an antibiotic-resistant, opportunistic pathogen - works together with C. difficile, reshaping and enhancing the metabolic environment in the gut so that C. difficile can thrive. Children's Hospital of Philadelphia /articles/chop-study-finds-multiple-disparities-in-completing-care-after-concussions/?sc=rsin /articles/chop-study-finds-multiple-disparities-in-completing-care-after-concussions/?sc=rsin Tue, 15 Nov 2022 09:45:02 EST Researchers found disparities in the completion of follow-up concussion care, particularly among pediatric patients who are publicly insured and identify as Black, suggesting barriers to care exist. Children's Hospital of Philadelphia /articles/chop-researchers-find-financial-strain-due-to-covid-19-pandemic-took-significant-toll-on-adolescent-mental-health/?sc=rsin /articles/chop-researchers-find-financial-strain-due-to-covid-19-pandemic-took-significant-toll-on-adolescent-mental-health/?sc=rsin Tue, 15 Nov 2022 09:35:55 EST Financial stress due to the COVID-19 pandemic took a distinct toll on adolescent mental health and contributed to depressive symptoms, according to a new study by researchers at Children's Hospital of Philadelphia (CHOP). Children's Hospital of Philadelphia