Newswise Feature Channel: Drug Resistance

New compound effective against flesh-eating bacteria

Washington University in St. Louis — Fri, 02 Aug 2024 14:00:00 EST

Researchers at Washington University School of Medicine in St. Louis have developed a compound that is effective against common bacteria that can lead to rare, dangerous illnesses.

Researchers develop a way to make lifesaving phages accessible, transportable and much easier to use

McMaster University — Thu, 11 Jul 2024 05:00:00 EST

Researchers have developed a simple new way to store, identify, and share phages, making them more accessible to clinicians trying to save patients with antimicrobial-resistant superbugs.

Multidrug-resistant fungi found in commercial soil, compost, flower bulbs

University of Georgia — Tue, 25 Jun 2024 08:05:45 EST

That pile of soil you bought at the home improvement store may contain more than just dirt, according to new research from the University of Georgia. A new UGA study found high levels of multidrug-resistant fungi in commercially available compost, soil and flower bulbs. Aspergillus fumigatus is a widespread fungus that thrives in soil. But it also poses a serious risk to human health if inhaled. People with compromised immune systems are particularly vulnerable to the opportunistic fungus, facing a near 100% fatality rate if infected with a multidrug-resistant strain.

Study reveals unexpected mechanism of drug resistance in kidney cancer

UT Southwestern Medical Center — Tue, 11 Jun 2024 16:05:39 EST

For nearly two decades, how kidney cancer becomes resistant to rapalog drugs has baffled the scientific community. Now a study by researchers at UT Southwestern Medical Center's Kidney Cancer Program sheds light.

Moffitt Study Reveals New Mechanism of Drug Resistance in Melanoma Leptomeningeal Disease

Moffitt Cancer Center — Tue, 11 Jun 2024 11:05:58 EST

Leptomeningeal disease is a rare but lethal complication faced by late-stage melanoma patients. It occurs when cancer cells spread to the membranes covering the brain and spinal cord, or the leptomeninges. This condition, which affects 5% to 8% of melanoma patients, often leads to rapid deterioration and is notoriously resistant to therapies. However, a new Moffitt Cancer Center study, published today in Cell Reports Medicine, uncovers the mechanisms that drive this drug resistance, offering new avenues for potential treatments.

Ketamine, anesthetics for depression let anesthesiologists and psychiatrists collaborate on new treatments

American Society of Anesthesiologists (ASA) — Mon, 10 Jun 2024 10:00:00 EST

Novel inhibitor insights offer pathway to preventing PXR-associated drug resistance

St. Jude Children's Research Hospital — Tue, 14 May 2024 16:05:30 EST

Scientists at St. Jude Children's Research Hospital uncovered a route to blocking activity of protein notorious for eliminating drugs, offering a potential boon to cancer therapy.

3i Symposium Inspires Interdisciplinary Insights in Immunology, Inflammation, and Infection

University of Utah Health — Thu, 09 May 2024 17:05:54 EST

Over 150 researchers from across the University of Utah gathered to form new connections and share groundbreaking research on topics from antibiotic resistance to autoimmune diseases.

Researchers resolve old mystery of how phages disarm pathogenic bacteria

Texas A&M AgriLife — Mon, 15 Apr 2024 08:05:14 EST

New study details long-sought mechanisms and structures

Johns Hopkins Expert Briefing on Malaria - Current Research, Transmission Risks, and Reasons for Optimism

Johns Hopkins Bloomberg School of Public Health — Mon, 08 Apr 2024 08:50:45 EST

Wound Treatment Gel Fights the Battle Against Antibacterial Resistance

American Institute of Physics (AIP) — Tue, 02 Apr 2024 11:00:00 EST

Polymer-based hydrogels are used to treat skin ailments and in tissue engineering because of their ability to retain water, deliver drugs into wounds, and biodegrade. However, they are complicated to manufacture and not very resilient to external forces like rubbing against clothing, sheets, or wound dressings.

UC Irvine-led research team discovers role of key enzymes that drive cancer mutations

University of California, Irvine — Mon, 18 Mar 2024 17:05:12 EST

A research team led by the University of California, Irvine has discovered the key role that the APOBEC3A and APOBEC3B enzymes play in driving cancer mutations by modifying the DNA in tumor genomes, offering potential new targets for intervention strategies.

Case Western Reserve University researchers report rise in global fungal drug-resistant infections

Case Western Reserve University — Mon, 18 Mar 2024 09:00:51 EST

A global wave of infections caused by fungi growing drug-resistant has the medical community issuing precautions on how to protect yourself.

Some lymphomas become resistant to treatment. Gene discovery may offer path to overcome it.

University of Wisconsin-Madison — Fri, 15 Mar 2024 15:05:03 EST

Patients with some types of lymphoma that become resistant to standard treatments may benefit from a therapy that University of Wisconsin-Madison researchers are evaluating after they discovered a key process that fuels the blood cancers' resistance to current drugs.

Anti-vaccine conspiracies fuel divisive political discourse

University of Tokyo — Mon, 26 Feb 2024 21:05:42 EST

Heightened use of social media during the coronavirus pandemic brought with it an unprecedented surge in the spread of misinformation.

Long COVID can happen to anyone. Keep up with the latest research on Long COVID on Newswise

Newswise — Wed, 21 Feb 2024 14:05:03 EST

Stay informed! These are the latest research articles on "Long COVID" from the Coronavirus News Source on Newswise.

RUDN pharmacists proposed ways to increase the activity of levofloxacin and overcome bacterial resistance to antimicrobial agents

Scientific Project Lomonosov — Wed, 21 Feb 2024 09:15:03 EST

RUDN University pharmacists modeled derivative molecules of the antibacterial levofloxacin to find out what biological functions its individual structural fragments - pharmacophores - are responsible for. This is necessary to increase the effectiveness of the drug, as bacteria become increasingly resistant to antibiotics.

New model identifies drugs that shouldn't be taken together

Massachusetts Institute of Technology (MIT) — Wed, 21 Feb 2024 02:05:01 EST

Any drug that is taken orally must pass through the lining of the digestive tract. Transporter proteins found on cells that line the GI tract help with this process, but for many drugs, it's unknown which of those transporters they use to exit the digestive tract.

UIC research helps create new antibiotic that evades bacterial resistance

University of Illinois Chicago — Thu, 15 Feb 2024 14:00:35 EST

New drug inspired by images that captured how bacteria block antibiotic activity

Mejora del proceso de evaluacion de la cirugia de la epilepsia: formacion y comunicacion

International League Against Epilepsy — Wed, 07 Feb 2024 10:05:49 EST

Aunque la cirugia puede ser una opcion para hasta el 40% de las personas con epilepsia resistente a los medicamentos, menos del 1% son remitidos a centros de epilepsia cada ano. ?Por que?