Newswise Feature Channel: Drug Resistance

Lasso-Shaped Antibiotic Co-Developed by UIC Evades Standard Drug Resistance

University of Illinois Chicago — Wed, 26 Mar 2025 12:00:15 EST

A small molecule shaped like a lasso may be a powerful tool in the fight against infectious diseases, according to a new study in Nature co-authored by University of Illinois Chicago researchers.

A Breakthrough Moment: McMaster Researchers Discover New Class of Antibiotics

McMaster University — Wed, 26 Mar 2025 12:00:00 EST

A McMaster University team led by renowned researcher Gerry Wright has identified a strong candidate to challenge even some of the most drug-resistant bacteria on the planet: a new molecule called lariocidin.

To Overcome Antibiotic Resistance, New Research Says to Let It Flow

College of Liberal Arts and Sciences, University of Illinois Urbana-Champaign — Thu, 20 Mar 2025 18:15:36 EST

Some notoriously difficult to treat infections may not be as resistant to antibiotics as has been thought, according to University of Illinois research using a microfluidic device that more closely duplicates the fluid flow found in the body.

Improving Epilepsy Surgery by Pinpointing Where Seizures Begin

University of California, San Francisco (UCSF) — Tue, 18 Mar 2025 08:00:00 EST

The study, appearing in the March 25 edition of eBioMedicine (open-access journal from The Lancet), found that using intracranial EEG recordings with high-density arrays resulted in better appraisals and better agreement about the location of SOZ among the epileptologists, compared to lower-density recordings.

New CRISPR-Based Diagnostic Test Detects Pathogens in Blood Without Amplification

University Of Illinois Grainger College Of Engineering — Fri, 14 Mar 2025 20:50:49 EST

UC Irvine Scientists Invent New Drug Candidates to Treat Antibiotic-Resistant Bacteria

University of California, Irvine — Mon, 24 Feb 2025 19:05:39 EST

Irvine, Calif., Feb. 24, 2025 -- There's an arms race in medicine - scientists design drugs to treat lethal bacterial infections, but bacteria can evolve defenses to those drugs, sending the researchers back to square one. In the Journal of the American Chemical Society, a University of California, Irvine-led team describes the development of a drug candidate that can stop bacteria before they have a chance to cause harm.

Why Anti-TNF Drugs Don't Work for Some Kids with Crohn's Disease

Michigan Medicine - University of Michigan — Wed, 12 Feb 2025 21:55:58 EST

Research from Michigan Medicine has investigated possible genetic factors for drug efficacy for children with Crohn's disease. In this latest study, HLA DQA1*05 positive children just taking anti-TNF mediation had the highest rate of drug failure.

Diabetes Can Drive the Evolution of Antibiotic Resistance

University of North Carolina School of Medicine — Wed, 12 Feb 2025 14:00:00 EST

Researchers at the UNC School of Medicine have proven that antibiotic-resistant strains of a harmful bacteria thrive in a diabetic infection environment.

Tackling the Threat of Drug-Resistant E. Coli in China

Chinese Academy of Sciences — Mon, 10 Feb 2025 09:15:49 EST

A comprehensive seven-year study across 20 Chinese provinces has revealed a concerning rise in antimicrobial resistance (AMR) among diarrheagenic Escherichia coli (E. coli), a major foodborne pathogen. Analyzing 9,068 isolates from sporadic human diarrhea cases, the research paints a troubling picture: the majority of isolates are resistant to at least one antimicrobial agent, with many demonstrating multidrug resistance. These findings are critical for shaping clinical antibiotic treatment strategies and prioritizing efforts to curb the spread of resistance.

The Wistar Institute Scientists Discover New Weapon to Fight Treatment-Resistant Melanoma

Wistar Institute — Wed, 05 Feb 2025 19:50:57 EST

The Wistar Institute scientists have identified a new strategy for attacking treatment-resistant melanoma: inhibiting the gene S6K2.

Study Finds Three New Safe, Effective Ways To Treat Drug-Resistant Tuberculosis

Harvard Medical School — Wed, 29 Jan 2025 17:00:00 EST

* Study finds three new safe and effective drug regimens to fight multidrug-resistant TB * The treatments, which include recently discovered TB drugs, give new options for shorter, personalized treatment and are cleared for use for more people than ever

Researchers Testing Antibody to Treat Drug-Resistant Bacteria

West Virginia University — Tue, 28 Jan 2025 09:45:03 EST

West Virginia University microbiologists have identified an antibody that can kill one of the most drug-resistant bacteria. Now, supported by a $3.5 million grant from the National Institute of Allergy and Infectious Diseases, they want to determine whether it can be combined with other antibiotics to produce a potent treatment against infection.

Drug Candidate Eliminates Breast Cancer Tumors in Mice in a Single Dose

American Chemical Society (ACS) — Wed, 22 Jan 2025 08:00:00 EST

Researchers reporting in ACS Central Science have created a novel treatment that eliminated small breast tumors and significantly shrank large tumors in mice in a single dose, without problematic side effects.

HealthTrackRx Expands Operations with New Campus at UPS Healthcare Labport Facility in Louisville, Enhancing Capabilities for Faster, More Affordable Diagnostic Testing

HealthTrackRx — Thu, 16 Jan 2025 09:10:13 EST

HealthTrackRx, the nation's premier molecular diagnostic laboratory for infectious diseases, today announced the opening of its newest campus at the state-of-the-art UPS Healthcare Labport facility in Louisville.

Overcoming Resistance: McMaster Researchers Find New Utility for Old Antibiotics

McMaster University — Mon, 06 Jan 2025 16:55:11 EST

Researchers at McMaster University have discovered a critical vulnerability in drug-resistant bacteria: zinc -- or a lack thereof.

The FC428 Clone: Tracking Global Transmission of Drug-Resistant Gonorrhea

Chinese Academy of Sciences — Mon, 30 Dec 2024 06:30:58 EST

The emergence of Neisseria gonorrhoeae strains resistant to ceftriaxone, the last reliable treatment, poses significant public health threats. The global spread of the FC428 clone, carrying penA allele 60.001, is of particular concern due to its association with high-level ceftriaxone resistance and frequent treatment failures.

A Public Health Emergency Is Waiting at the Bottom of the Antibiotic Resistance Cliff

Northern Arizona University — Thu, 26 Dec 2024 05:00:00 EST

New research led by Northern Arizona University showed that it's not if, but when we will see pan-resistance.

Battling Breast Cancer: New Insights Into Angiogenesis and Drug Resistance

Chinese Academy of Sciences — Wed, 11 Dec 2024 07:05:14 EST

Breast cancer's resistance to treatment is a major hurdle in improving patient outcomes. A recent study explores how tumor angiogenesis--the formation of abnormal blood vessels in tumors--plays a pivotal role in fostering drug resistance. The research highlights how these blood vessels hinder drug delivery and create a hostile tumor environment, reducing the effectiveness of therapies. It also investigates the potential of anti-angiogenic treatments to normalize these vessels, enhancing drug efficacy and offering new hope for patients.

A New Approach to Predicting Malaria Drug Resistance

University of California San Diego — Thu, 28 Nov 2024 17:00:00 EST

Researchers at UC San Diego analyzed the genomes of hundreds of malaria parasites to determine which genetic variants are most likely to confer drug resistance.

For People Living with HIV/AIDS, TB is Still the Leading Cause of Death

American Thoracic Society (ATS) — Wed, 27 Nov 2024 10:00:54 EST

The latest World Health Organization's Global Tuberculosis Report released in November 2024 painted a sobering picture; approximately 8.2 million people were newly diagnosed with TB in 2023, the highest number since the organization began global TB monitoring in 1995. TB is the leading cause of death among those with HIV /AIDS worldwide. According to the WHO, in 2023, 161,000 people died of HIV-associated TB.