Newswise Focus Channel: Stem Cells

Hidden Forces Shape Plants From the Inside Out

Universite de Montreal — Wed, 09 Apr 2025 18:30:27 EST

UdeM scientists use a combination of experimental data and modelling to reveal how physical forces help plants to generate their complex 3D shapes.

Ventris Medical Receives Additional FDA Clearance for Backpack(r) Bone Graft in the Intervertebral Disc Space

Ventris Medical — Tue, 08 Apr 2025 07:05:46 EST

Ventris Medical, a privately held orthobiologics and tissue regeneration company, today announced that the United States Food and Drug Administration has granted 510(k) clearance for Backpack(r) (Porous Biologic Scaffold, K250556) for use in the Intervertebral Disc Space.

Curious by Nature: Dr. Gilbert Bernier - Can Stem Cells Cure Blindness?

Newswise — Fri, 04 Apr 2025 17:50:37 EST

Dr. Gilbert Bernier, a neuroscientist and professor at the University of Montreal who is pushing the boundaries of regenerative medicine.

NK Cells Complexed with Bispecific Antibody Yield High Response Rates in Patients with Lymphoma

University of Texas MD Anderson Cancer Center — Fri, 04 Apr 2025 05:00:00 EST

A novel cell therapy approach using cord blood-derived natural killer (NK) cells pre-complexed with AFM13, or acimtamig, a CD30/CD16A bispecific antibody, was safe and generated strong response rates for patients with refractory CD30-positive lymphomas, according to a new study from The University of Texas MD Anderson Cancer Center.

New Method Creates 854x More Mitochondria, Offering Hope for Cartilage Regeneration

Chinese Academy of Sciences — Mon, 31 Mar 2025 06:10:32 EST

Scientists have unveiled a revolutionary method for mass-producing high-quality human mitochondria, potentially transforming treatments for degenerative diseases. By refining stem cell culture conditions, researchers achieved an extraordinary 854-fold increase in mitochondrial production while significantly enhancing energy output.

Regulation of lncRNA-ENST on Myc-Mediated Mitochondrial Apoptosis in Mesenchymal Stem Cells: In Vitro Evidence Implicated for Acute Lung Injury Therapeutic Potential

World Journal of Stem Cells — Wed, 26 Mar 2025 12:00:38 EST

BACKGROUNDAcute lung injury (ALI) is a fatal and heterogeneous disease. While bone marrow mesenchymal stem cells (BMSCs) have shown promise in ALI repair, their efficacy is compromised by a high apoptotic percentage. Preliminary findings ha

Emerging Role of Mesenchymal Stem Cell-Derived Exosomes in the Repair of Acute Kidney Injury

World Journal of Stem Cells — Wed, 26 Mar 2025 12:00:25 EST

Acute kidney injury (AKI) is a clinical syndrome characterized by a rapid deterioration in kidney function and has a significant impact on patient health and survival. Mesenchymal stem cells (MSCs) have the potential to enhance renal functi

Immunomodulatory Effects and Clinical Application of Exosomes Derived From Mesenchymal Stem Cells

World Journal of Stem Cells — Wed, 26 Mar 2025 12:00:14 EST

Exosomes (Exos) are extracellular vesicles secreted by cells and serve as crucial mediators of intercellular communication. They play a pivotal role in the pathogenesis and progression of various diseases and offer promising avenues for the

Cyclodextrin Host-Guest Complex to Facilitate Sinomenine-Based Osteoporosis Therapy

World Journal of Stem Cells — Wed, 26 Mar 2025 12:00:12 EST

Xiao et al reported on the natural product sinomenine (SIN), which is a traditional Chinese medicine for treating osteoporosis via its modulation of autophagy; however, SIN was dissolved in dimethyl sulfoxide prior to administration, which

DNA Methyltransferase 1/miR-342-3p/Forkhead box M1 Signaling Axis Promotes Self-Renewal in Cervical Cancer Stem-Like Cells in Vitro and Nude Mice Models

World Journal of Stem Cells — Wed, 26 Mar 2025 12:00:11 EST

BACKGROUNDCervical cancer (CC) stem cell-like cells (CCSLCs), defined by the capacity of differentiation and self-renewal and proliferation, play a significant role in the progression of CC. However, the molecular mechanisms regulating thei

MiR-21-5p-enriched exosomes from hiPSC-derived cardiomyocytes exhibit superior cardiac repair efficacy compared to hiPSC-derived exosomes in a murine MI model

World Journal of Stem Cells — Wed, 26 Mar 2025 12:00:06 EST

BACKGROUNDHeart disease remains a leading cause of mortality worldwide, with existing treatments often failing to effectively restore damaged myocardium. Human-induced pluripotent stem cells (hiPSCs) and their derivatives offer promising th

Efficacy Equivalence but Hidden Hurdles: Can Serum-Free Human Umbilical Cord Mesenchymal Stem Cells Translate to Clinically Superior Osteoarthritis Therapy

World Journal of Stem Cells — Wed, 26 Mar 2025 12:00:03 EST

This article discusses the study by Xiao et al, which investigated the therapeutic efficacy of serum-free cultured human umbilical cord mesenchymal stem cells (N-hUCMSCs) in a mouse model of knee osteoarthritis. The results showed that N-hU

Clinical Experience with Cryopreserved Mesenchymal Stem Cells for Cardiovascular Applications: A Systematic Review

World Journal of Stem Cells — Wed, 26 Mar 2025 12:00:02 EST

BACKGROUNDAs living biodrugs, mesenchymal stem cells (MSCs) have progressed to phase 3 clinical trials for cardiovascular applications. However, their limited immediate availability hampers their routine clinical use. AIMTo validate our hy

Mesenchymal Stem Cell Exosomes Enhance the Development of Hair Follicle to Ameliorate Androgenetic Alopecia

World Journal of Stem Cells — Wed, 26 Mar 2025 12:00:00 EST

BACKGROUNDMesenchymal stem cells (MSCs) and their secretome have significant potential in promoting hair follicle development. However, the effects of MSC therapy have been reported to vary due to their heterogeneous characteristics. Differ

Stem Cell Trial for Early Alzheimer's Disease Begins at UTHealth Houston

University of Texas Health Science Center at Houston — Fri, 14 Mar 2025 10:15:52 EST

A stem cell therapy trial aimed at reducing neuroinflammation in patients with presymptomatic Alzheimer's disease is underway at UTHealth Houston.

Children's Hospital of Philadelphia Preclinical Study Demonstrates Improved Gene Therapy Approach to Treating Metachromatic Leukodystrophy

Children's Hospital of Philadelphia — Tue, 11 Mar 2025 19:20:06 EST

In a preclinical study, researchers at Children's Hospital of Philadelphia (CHOP) demonstrated a novel gene therapy with potentially increased effectiveness and safety for the treatment for metachromatic leukodystrophy (MLD), a rare disease in young children characterized by the deficient activity of a critical enzyme.

VUMC Part of New Study Validating Curative Therapy for Sickle Cell Disease

Vanderbilt University Medical Center — Tue, 04 Mar 2025 10:50:20 EST

A modified bone marrow transplant procedure for sickle cell disease (SCD) co-developed at Vanderbilt University Medical Center, Johns Hopkins University School of Medicine, and the University of California, San Francisco, can cure the disease, a new study has found.

Research Tip Sheet: New Single-Cell Proteomics Technology Reveals Heart Cell Differences

Cedars-Sinai — Tue, 04 Mar 2025 04:00:20 EST

A multidisciplinary team of Cedars-Sinai investigators has used a novel single-cell proteomics approach to better understand the differences between naturally occurring adult heart cells and heart cells derived from induced pluripotent stem cells.

Treatment Strategy Reprograms Brain Cancer Cells, Halting Tumor Growth

University of California, Los Angeles (UCLA), Health Sciences — Wed, 26 Feb 2025 17:25:50 EST

UCLA scientists have identified a potential new strategy for treating glioblastoma, the deadliest form of brain cancer, by reprogramming aggressive cancer cells into harmless ones.

Asthma and Stem Cell Therapy

World Journal of Stem Cells — Wed, 26 Feb 2025 12:00:49 EST

The global incidence of asthma, a leading respiratory disorder affecting more than 235 million people, has dramatically increased in recent years. Characterized by chronic airway inflammation and an imbalanced response to airborne irritants