Newswise Curated News Channel: National Institute of Neurological Disorders and Stroke (NINDS)

Mystery Solved: New Study Reveals How DNA Repair Genes Play a Major Role in Huntington's Disease

University of California, Los Angeles (UCLA), Health Sciences — Tue, 11 Feb 2025 11:00:00 EST

A new UCLA Health study has discovered in mouse models that genes associated with repairing mismatched DNA are critical in eliciting damages to neurons that are most vulnerable in Huntington's disease and triggering downstream pathologies and motor impairment, shedding light on disease mechanisms and potential new ways to develop therapies.

Cracking the Code of Drug Delivery: Using Computers and AI to Make Medicine Work Smarter

University of Portsmouth — Thu, 23 Jan 2025 10:25:47 EST

Cracking the code of drug delivery: using computers and AI to make medicine work smarter

Signaling Circuit Interplay Pushes Newborn Neurons Out of the Neuronal Nest

St. Jude Children's Research Hospital — Thu, 09 Jan 2025 02:50:38 EST

Scientists at St. Jude Children's Research Hospital have uncovered the intricate circuit cues behind neuronal cell maturation and migration, which is required for proper cognitive function.

Building a Multilayered Drug Delivery System That's Activated by Ultrasound

National Institute of Biomedical Imaging and Bioengineering — Fri, 20 Dec 2024 09:35:44 EST

Releasing a drug selectively in specific locations in the body, including the brain, has been challenging. Researchers at the University of Utah have tackled the problem by designing ultrasound-sensitive nanoparticles that release a drug at the targeted site when activated by focused ultrasound.

Repairing broken brain circuits may offer path to new Parkinson's treatments

Van Andel Institute — Thu, 24 Aug 2023 11:05:05 EST

Scientists have identified a series of processes that help the brain adapt to damage caused by breakdowns in circuits that govern movement, cognition and sensory perception.

UTHealth Houston joins SATURN trial, studying role of statins in recurrent intracerebral hemorrhage

University of Texas Health Science Center at Houston — Fri, 11 Aug 2023 09:55:30 EST

A clinical trial evaluating the role of statins in the risk of recurrent intracerebral hemorrhage (ICH) in patients presenting with ICH, has opened for enrollment at UTHealth Houston.

UTHealth Houston researcher awarded $3.1M NIH grant to study sudden unexpected death in epilepsy

University of Texas Health Science Center at Houston — Tue, 08 Aug 2023 13:10:04 EST

A five-year, $3.1 million grant to study preventive strategies for sudden unexpected death in epilepsy (SUDEP) has been awarded to UTHealth Houston by the National Institutes of Health (NIH) National Institute of Neurological Disorders and Stroke.

New Community Partnership Model Boosts Inclusion of Participants into HIV Cure-Directed Research

Wistar Institute — Wed, 19 Jul 2023 12:05:09 EST

Scientists have long used community advisory boards to engage communities and provide feedback on studies, but this model has limitations. Now, Wistar Institute researchers are sharing how a more inclusive model for community engagement can lead to deeper insights and greater community participation in HIV research.

Tracing maternal behavior to brain immune function

Ohio State University — Wed, 19 Jul 2023 11:30:20 EST

Immune system changes in the pregnant body that protect the fetus appear to extend to the brain, where a decrease in immune cells late in gestation may factor into the onset of maternal behavior, new research in rats suggests.

Air monitor can detect COVID-19 virus variants in about 5 minutes

Washington University in St. Louis — Mon, 10 Jul 2023 08:30:09 EST

Now that the emergency phase of the COVID-19 pandemic has ended, scientists are looking at ways to surveil indoor environments in real time for viruses. By combining recent advances in aerosol sampling technology and an ultrasensitive biosensing technique, researchers at Washington University in St. Louis have created a real-time monitor that can detect any of the SARS-CoV-2 virus variants in a room in about 5 minutes.

Different areas of the brain activated depending on structural complexity of music, language

University of Texas Health Science Center at Houston — Wed, 05 Jul 2023 10:15:58 EST

Distinct, though neighboring, areas of the brain are activated when processing music and language, with specific sub-regions engaged for simple melodies versus complex melodies, and for simple versus complex sentences, according to research from UTHealth Houston.

Cancerous brain tumor cells may be at 'critical point' between order and disorder, study suggests

Michigan Medicine - University of Michigan — Thu, 29 Jun 2023 06:00:31 EST

Glioblastoma cells are poised near a "critical point" of order and disorder -- meaning, the cells possess some form of large-scale coordination throughout the whole tumor that allows them to respond in practical unison to attempts to kill tumor cells, such as chemotherapy or radiation, a study suggests. Researchers say disrupting the large-scale organization of brain tumors may result in more powerful ways to treat and one day eliminate brain tumors.

Scientists identify the first genetic marker for MS severity

University of Cambridge — Wed, 28 Jun 2023 11:00:00 EST

A study of more than 22,000 people with multiple sclerosis has discovered the first genetic variant associated with faster disease progression, which can rob patients of their mobility and independence over time.

Is TBI a Chronic Condition?

American Academy of Neurology (AAN) — Wed, 21 Jun 2023 16:00:00 EST

People with TBI may continue to improve or decline years after their injury, making it a more chronic illness, according to a study published in the June 21, 2023, online issue of Neurology(r), the medical journal of the American Academy of Neurology.

Scientists develop universal donor stem cell therapy to treat degenerative brain diseases in a preclinical study

City of Hope — Thu, 15 Jun 2023 17:10:06 EST

Scientists at City of Hope have developed universal donor stem cells that could one day provide lifesaving therapy to children with lethal brain conditions, such as Canavan disease, as well as to people with other degenerative diseases, such as Alzheimer's and multiple sclerosis.

Researchers to Explore Potential of New Treatment Against Vascular Dementia

University of Texas at El Paso — Thu, 08 Jun 2023 17:20:22 EST

Researchers from The University of Texas at El Paso's School of Pharmacy will explore the viability of a new treatment for vascular dementia, thanks to a $2.2 million grant from the National Institutes of Health National Institute of Neurological Disorders and Stroke.

Deep-brain stimulation during sleep strengthens memory

University of California, Los Angeles (UCLA), Health Sciences — Thu, 01 Jun 2023 12:00:00 EST

This study provides provides the first physiological evidence from inside the human brain supporting the dominant scientific theory on how the brain consolidates memory during sleep. Further, deep-brain stimulation during a critical time in the sleep cycle appeared to improve memory consolidation.

Flexible nanoelectrodes can provide fine-grained brain stimulation

Rice University — Tue, 30 May 2023 19:50:59 EST

According to a study published in Cell Reports, the tiny implantable devices formed stable, long-lasting and seamless tissue-electrode interfaces with minimal scarring or degradation in rodents.

Distinct types of cerebellar neurons control motor and social behaviors

Texas Children's Hospital — Mon, 15 May 2023 19:25:14 EST

The cerebellum, a major part of the hindbrain in all vertebrates, is important for motor coordination, language acquisition, and regulating social and emotional behaviors. A study led by Dr. Roy Sillitoe, professor of Pathology and Neuroscience at Baylor College of Medicine and investigator at the Jan and Dan Duncan Neurological Research Institute (Duncan NRI) at Texas Children's Hospital, shows two distinct types of cerebellar neurons differentially regulate motor and non-motor behaviors during development and in adulthood.

Discovery suggests route to safer pain medications

Washington University in St. Louis — Wed, 03 May 2023 11:00:00 EST

Strategies to treat pain without triggering dangerous side effects such as euphoria and addiction have proven elusive. Now scientists at Washington University School of Medicine have identified a potential pathway to pain relief that neither triggers addiction nor causes hallucinations.