Newswise Feature Channel: Liver Disease

Diesel Exhaust Exposure Led to Disarray in Liver Function in Mice

University of California, Los Angeles (UCLA), Health Sciences — Tue, 04 Mar 2025 11:00:46 EST

STIM1: The Cancer Shield Against Sorafenib Unmasked

Chinese Academy of Sciences — Tue, 04 Mar 2025 08:20:58 EST

A recent study unveils how stromal interaction molecule 1 (STIM1), a protein involved in calcium signaling, plays a pivotal role in the resistance of liver cancer to sorafenib, a key treatment for advanced hepatocellular carcinoma (HCC).

Metabolic Shift in Liver Cancer: How PDHX Acetylation Drives Tumor Growth

Chinese Academy of Sciences — Mon, 03 Mar 2025 05:50:37 EST

A recent study has unveiled a new mechanism driving hepatocellular carcinoma (HCC) progression through the acetylation of pyruvate dehydrogenase complex (PDC) component X (PDHX), a critical component of the PDC. This modification disrupts PDC assembly, inhibits its function, and shifts metabolism towards aerobic glycolysis, promoting tumor growth. The findings highlight PDHX acetylation as both a potential biomarker and therapeutic target, offering new possibilities for liver cancer treatment and advancing our understanding of cancer cell metabolism.

Cedars-Sinai Sets New Record in Organ Transplantation

Cedars-Sinai — Fri, 28 Feb 2025 18:45:11 EST

The Cedars-Sinai Comprehensive Transplant Center and the Smidt Heart Institute set a new record in 2024 by completing 682 solid organ transplants--the most the medical center has performed in a year--as patient survival outcomes continued to meet or exceed the national average.

Artificial Intelligence Helps Find Undiagnosed Liver Disease

Cedars-Sinai — Thu, 27 Feb 2025 19:10:40 EST

An artificial intelligence (AI) program can identify chronic liver disease from videos taken during a common heart test known as an echocardiogram, Cedars-Sinai investigators report.

How Solving a Hepatitis B Paradox Opened the Door to New Therapies

Rockefeller University — Thu, 27 Feb 2025 16:50:21 EST

Procedimiento doble combina trasplante de higado y cirugia bariatrica

Mayo Clinic — Thu, 27 Feb 2025 11:10:02 EST

Cirujanos de Mayo Clinic descubrieron que un enfoque innovador puede ayudar a los pacientes con obesidad a recibir atencion vital. La obesidad puede ser una barrera para el transplante de higado. La Dra. Julie Heimbach, directora del Centro de Trasplantes de Mayo Clinic en Rochester, Minnesota, afirma que la combinacion de la cirugia de manga gastrica, un tipo de cirugia bariatrica, con el trasplante de higado, es eficaz para hacer frente a ambos problemas de salud.

Induced pluripotent stem cell-derived mesenchymal stem cells for modeling and treating metabolic associated fatty liver disease and metabolic associated steatohepatitis: Challenges and opportunities

World Journal of Stem Cells — Wed, 26 Feb 2025 12:00:34 EST

The potential of induced pluripotent stem cells (iPSCs) for modeling and treating metabolic associated fatty liver disease (MAFLD) and metabolic associated steatohepatitis (MASH) is emerging. MAFLD is a growing global health concern, curren

Yale Gynecology Chair: Endometriosis-Associated microRNAs Impact Liver Metabolism

Yale School of Medicine — Mon, 24 Feb 2025 18:55:29 EST

Study: Endometriosis-Linked microRNAs Help Regulate Liver Metabolism

Yale School of Medicine — Mon, 24 Feb 2025 17:40:57 EST

'Deaths of Despair' More than Double in the U.S. Over Two Decades

Florida Atlantic University — Thu, 20 Feb 2025 08:30:31 EST

A study finds a troubling rise in 'deaths of despair' in the U.S. from 1999 to 2021, using the International Classification of Diseases. These deaths, defined by 19 underlying causes such as chronic hepatitis, liver cirrhosis, suicide, drug overdoses, and alcohol-related conditions, increased two-and-a-half-fold over two decades. By 2021, deaths of despair would have become the fifth leading cause of death in the U.S., surpassing 176,000 fatalities, and ranking just behind heart disease, cancer, COVID-19 and accidents.

How Livers Regenerate and Why That Matters

Children's Hospital Los Angeles — Fri, 14 Feb 2025 09:35:47 EST

The liver is an underappreciated, but dependable organ with superhero-like powers.

Semaglutide Shows Promise in Reducing Cravings for Alcohol, Heavy Drinking

University of North Carolina School of Medicine — Wed, 12 Feb 2025 19:35:54 EST

Randomized, placebo-controlled trial finds that low-dose semaglutide reduces amount of alcohol consumption, alcohol cravings, and heavy drinking days. Reductions in cigarettes per day were also seen.

The Latest Developments on Cancer Research and Liver Transplantation Outcomes Are Among the Topics to Be Highlighted at the Annual Academic Surgical Congress

University of California, Los Angeles (UCLA), Health Sciences — Mon, 10 Feb 2025 20:35:49 EST

The latest developments in breast lesion detection, robotic cancer resection, liver transplantation, and pancreatic cancer tumor detection are some of the topics to be covered by UCLA doctors and scientists at the 20th annual Academic Surgical Congress (ASC).

Why Some Heavy Drinkers Develop Advanced Liver Disease, While Others Do Not

Keck Medicine of USC — Thu, 06 Feb 2025 11:00:11 EST

A new study from Keck Medicine of USC finds that heavy drinkers with either diabetes, high blood pressure or a high waist circumference are as much as twice as likely to develop advanced liver disease

ACG-ASGE Quality Indicators for Upper GI Endoscopy and More in the February Issue of AJG

American College of Gastroenterology (ACG) — Wed, 05 Feb 2025 08:00:26 EST

The February issue of The American Journal of Gastroenterology highlights new clinical science and reviews, including joint ACG-ASGE quality indicators for upper GI endoscopy, the first medication for the treatment of at-risk MASH, and a digital gut-directed hypnotherapy program for IBS.

Study Sheds Light on Liver Maturation, Specialization

College of Liberal Arts and Sciences, University of Illinois Urbana-Champaign — Mon, 03 Feb 2025 20:25:31 EST

Researchers from the University of Illinois have identified a key process coordinating liver maturation and polyploidization, a state in which cells carry more than two sets of chromosomes. Their findings provide insight into hepatocyte specialization that will aid efforts in regenerative medicine.

How UIC Scientists Redesigned an Effective Cancer Therapy to Make It Safer

University of Illinois Chicago — Fri, 31 Jan 2025 17:10:51 EST

University of Illinois Chicago scientists have redesigned a treatment for the most common pediatric leukemia to eliminate its severe side effects, like blood clots and liver damage. If approved, the new drug may be tolerated by a broader range of leukemia patients and even be used to treat other cancers.

Children's Hospital Los Angeles has Best Pediatric Liver Transplant Survival Rates in the Country

Children's Hospital Los Angeles — Tue, 28 Jan 2025 09:00:31 EST

Children's Hospital Los Angeles has the best one-and three-year post-transplant patient and graft survival rates in the nation for pediatric liver transplants, according to newly released 2025 data from the Scientific Registry of Transplant Recipients (SRTR) and the Organ Procurement and Transplant Network (OPTN).

Weight-Loss Surgery Lowers Risk of Developing Complications of Liver Disease in Patients with Cirrhosis and Obesity

Cleveland Clinic — Mon, 27 Jan 2025 19:10:48 EST

A Cleveland Clinic study shows that patients with obesity and fatty liver-related cirrhosis who had bariatric (weight-loss) surgery significantly lowered their future risk of developing serious liver complications compared with patients who received medical therapy alone. The results were published in Nature Medicine journal.